DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zda and fkbp8

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_957178.1	Gene:	fkbp8 / 393858	ZFINID:	ZDB-GENE-040426-1849	Length:	406	Species:	Danio rerio

Alignment Length:	407	Identity:	128/407 - (31%)
Similarity:	207/407 - (50%)	Gaps:	60/407 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSSSFEDLTNAEDTKDIRKVAAEEAASGDGAPPASVSGDGQK--------------AEEEDAEEE 57
            |...||.|.:.||..|            |..||...:|.|:|              ||...||.|
Zfish    31 SREDFEMLEHLEDDVD------------DDLPPLEDAGGGKKKSSPAKDPAKEDKSAESPSAEPE 83

  Fly    58 --CDILGNKQLIKRTIKK-APQDSFRRPIRGELVTVNFTGKLDNGTVVENELNFQCHVGDYEVIQ 119
              .|:|||.||.|:.::. |..||  ||.:|:.||::....|.|||||:...:....:||.:|:|
Zfish    84 EWLDVLGNGQLRKKVLEAGAGPDS--RPQKGQNVTIHLKTALTNGTVVDELKDLSFTLGDGDVLQ 146

  Fly   120 GLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKYEEFADLK- 183
            .||:.:.::::||.:.:...:::.||:|     |.|...|||||.|..|::||..  :|..||:
Zfish   147 ALDLTVQLMEMGEKALIEAAAKYAYGAL-----GSSAPAVPPDADLLLEVQLLSA--DEALDLEL 204

  Fly   184 ---SFEILRKYGTRKKERANFFYKRSEFTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDT 245
               |..|:  ...||:||.|..|:|:::..|::.|..||...:          ....:::|..:.
Zfish   205 MPPSERII--LANRKRERGNVHYQRADYAFAVNSYGIALQITE----------ASSRVDISQEEE 257

  Fly   246 QTLLEDRLIVYNNLAMTQIKIAAYDAALQSVEHVLRCQPNNSKALYRKGRILEGKADTQGAIKLL 310
            :.||:.::...||:|..|:|:..|:|||:|...||..||:|.|||:|||::|..:.:...|||.|
Zfish   258 EELLDMKVKCLNNMAAAQLKLDHYEAALRSCVSVLAHQPDNVKALFRKGKVLALQGEFAEAIKTL 322

  Fly   311 QKVATLEPENRAVQSDLARLFIKARREEHNEKEMYQKMLGQAKKMEQNTATRQKQPLVDNSKLKL 375
            :....|||.|:.:.::|::|..|...::..|:.||:||||     ..:.::.||.....:..|.
Zfish   323 KMALKLEPSNKTIHAELSKLVKKHSEQKGAEQAMYKKMLG-----NPSNSSVQKHRAKSSWGLS- 381

  Fly   376 LGYLMGTILIGVAGVAI 392
            ..:|.|...:.:.|||:
Zfish   382 WKWLFGATAVAIGGVAL 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	31/91 (34%)
		TPR_11	196..284	CDD:290150	24/87 (28%)
		TPR repeat	196..220	CDD:276809	8/23 (35%)
		TPR repeat	252..282	CDD:276809	12/29 (41%)
		TPR_11	255..318	CDD:290150	27/62 (44%)
		TPR repeat	287..313	CDD:276809	11/25 (44%)
		TPR repeat	321..349	CDD:276809	7/27 (26%)
fkbp8	NP_957178.1	FKBP_C	106..194	CDD:278674	33/94 (35%)
		TPR_11	214..296	CDD:290150	26/91 (29%)
		TPR repeat	214..259	CDD:276809	12/54 (22%)
		TPR repeat	265..293	CDD:276809	11/27 (41%)
		TPR_11	266..330	CDD:290150	27/63 (43%)
		TPR repeat	298..328	CDD:276809	12/29 (41%)
		TPR_1	299..332	CDD:278916	14/32 (44%)
		TPR repeat	333..361	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10461
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7720
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4040
OMA	1	1.010	-	-		QHG52673
OrthoDB	1	1.010	-	-		D248966at33208
OrthoFinder	1	1.000	-	-		FOG0006509
OrthoInspector	1	1.000	-	-		otm25297
orthoMCL	1	0.900	-	-		OOG6_106755
Panther	1	1.100	-	-	O	PTHR46512
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870