DRSC/TRiP Functional Genomics Resources

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Protein Alignment zda and fkbp5

DIOPT Version :10

Sequence 1:NP_611353.1 Gene:zda / 37144 FlyBaseID:FBgn0034368 Length:397 Species:Drosophila melanogaster
Sequence 2:XP_021332470.1 Gene:fkbp5 / 368924 ZFINID:ZDB-GENE-030616-630 Length:457 Species:Danio rerio


Alignment Length:499 Identity:101/499 - (20%)
Similarity:170/499 - (34%) Gaps:197/499 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 SSFEDL--TNAEDTKDIRKVAAEEAASGDGAPPASVSGDGQKAEEEDAEEECDILGNKQLIKRTI 71
            ||.||:  ||...|       |...:.|....|...||..:..::...|.|              
Zfish     6 SSLEDIFSTNQCPT-------AVFTSRGTAVTPNGDSGVCKIVKQHGVEGE-------------- 49

  Fly    72 KKAPQDSFRRPIRGELVTVNFTGKLDNGTVVENELN----FQCHVGDYEVIQGLDMVLPMLQVGE 132
                     ||:.|:.|.|::||:|.:|...::.|:    |..:||..:||:..|:.:..:|.||
Zfish    50 ---------RPMIGDRVFVHYTGRLLSGKKFDSSLDRKEPFVFNVGKGQVIKAWDICVCSMQKGE 105

  Fly   133 VSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKYEEFAD---------------- 181
            |..:.....:.|||.|      |...|||::.|.:|||||:.:.||..:                
Zfish   106 VCLMLCKPEYAYGSAG------SPPKVPPNSTLVFEIELLNFRGEELTEDGGIVRRIKVKGEGYS 164

  Fly   182 ----------------------------------------------------------------- 181
                                                                             
Zfish   165 NPNEGATVHVHLEGWCGGRLFDSRDVTFAVGESEDVGVPLGVDRAMEKLQKGECCLLYLKPKYAF 229

  Fly   182 ---------------------LKSFE------------------ILRKYGTRKKERANFFYKRSE 207
                                 ||.||                  ::::.||:       ::|...
Zfish   230 GKEGRKEHDIGSNAELLYEVTLKDFEKAKETWEMDLKEKLERAVLVKQKGTQ-------YFKAGR 287

  Fly   208 FTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLEDRLIVYNNLAMTQIKIAAYDAA 272
            :..|:..|:|.:::|:...|:     .||.|:.    .|.||   |:.:.|||:..:::..|...
Zfish   288 YNYAVIQYQRIVNWLEMECGN-----GKEQLQA----IQALL---LVAHLNLALCYLRLREYSQT 340

  Fly   273 LQSVEHVLRCQPNNSKALYRKG--RILEGKADTQGAIKLLQKVATLEPENRAVQSDLARLFIKAR 335
            :::...|:...|.|.|||||:|  |:|..:...  |:...::|..:...|||.:|.:.....|.|
Zfish   341 VENCNKVMELDPENEKALYRRGEARLLRNEFSL--ALMDFKQVLQVNSFNRAARSQILICQHKIR 403

  Fly   336 REEHNEKEMYQKMLG------------QAKKMEQNTATRQKQPL 367
            .....:|::|..|..            :.||.|...:.:.||.|
Zfish   404 EHHERDKKIYANMFQRFAEHDAKVCRLKRKKEESVISDQNKQGL 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zdaNP_611353.1 FKBP_C 80..172 CDD:459735 32/95 (34%)
Spy 196..>338 CDD:443119 36/143 (25%)
TPR repeat 196..220 CDD:276809 4/23 (17%)
TPR repeat 252..282 CDD:276809 6/29 (21%)
TPR repeat 287..313 CDD:276809 9/27 (33%)
TPR repeat 321..349 CDD:276809 7/27 (26%)
fkbp5XP_021332470.1 FKBP_C 49..139 CDD:459735 33/118 (28%)
FkpA 152..254 CDD:440311 2/101 (2%)
TPR 243..>407 CDD:440225 42/184 (23%)
TPR repeat 272..300 CDD:276809 6/34 (18%)
TPR repeat 320..350 CDD:276809 7/32 (22%)
TPR repeat 355..383 CDD:276809 10/29 (34%)

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