DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zda and Fkbp5

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_006256284.1	Gene:	Fkbp5 / 361810	RGDID:	1309155	Length:	473	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	100/481 - (20%)
Similarity:	174/481 - (36%)	Gaps:	164/481 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LTNAEDTKDI---RKVAAEEAASGDGAPPASVSGDGQKAEEEDAEEECDILGNKQLIKRTIKKAP 75
            :|:.|:.:..   |.:..:|..|.:...||:...:    :.||...:.| .|..:::||.
  Rat     3 VTSTEEAEVFYLQRTMTTDEGTSNNEENPAATVVE----QGEDITTKKD-RGVLKIVKRV----- 57

  Fly    76 QDSFRRPIRGELVTVNFTGKLDNGTVVENELN----FQCHVGDYEVIQGLDMVLPMLQVGEVSQV 136
            ..|...|:.|:.|.|::.|||.||...::..:    |...:|..:||:..|:.:..::.||:..:
  Rat    58 GTSEETPMIGDKVYVHYKGKLSNGKKFDSSRDRNEPFVFSLGKGQVIKAWDIGVSTMKKGEICHL 122

  Fly   137 SVDSRFGYGSLG-LKKEGESEYLVPPDAHLTYEIELLDIKYEE-FAD------------------ 181
            .....:.|||.| |.|       :|.:|.|.:||||||.|.|: |.|
  Rat   123 LCKPEYAYGSAGSLPK-------IPSNATLFFEIELLDFKGEDLFEDSGIIRRIKRKGEGYSNPN 180

  Fly   182 ----------------------------------------------------------------- 181

  Rat   181 EGATVEVHLEGCCAGRVFDCRDVVFVIGEGEDHDIPIGIDKALEKMQREEQCILYLGPQYGFGEA 245

  Fly   182 ------------------LKSFEILR---KYGTRK--------KERANFFYKRSEFTTAIHLYRR 217
                              |||||..:   :..|::        ||:...::|..::..|:..|.:
  Rat   246 GKPKFGIEPNAELMYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGK 310

  Fly   218 ALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLEDRLIVYNNLAMTQIKIAAYDAALQSVEHVLRC 282
            .:.:|:...|            ||..:::......|..:.||||..:|:..|..|::..:..|..
  Rat   311 IVSWLEMEYG------------LSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGL 363

  Fly   283 QPNNSKALYRKGRILEGKADTQGAIKLLQKVATLEPENRAVQSDLARLFI---KARREEHNEKE- 343
            ...|.|.|||:|.......:.:.|....:||..:.|:|:|     |||.|   :.:.:||||::
  Rat   364 DSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKA-----ARLQISVCQRKAKEHNERDR 423

  Fly   344 -----MYQKMLGQAKKMEQNTATRQK 364
                 |::|...|..|.|.:.|..:|
  Rat   424 RVYANMFKKFAEQDAKEEASKALSKK 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	28/96 (29%)
		TPR_11	196..284	CDD:290150	18/87 (21%)
		TPR repeat	196..220	CDD:276809	5/23 (22%)
		TPR repeat	252..282	CDD:276809	9/29 (31%)
		TPR_11	255..318	CDD:290150	17/62 (27%)
		TPR repeat	287..313	CDD:276809	6/25 (24%)
		TPR repeat	321..349	CDD:276809	11/36 (31%)
Fkbp5	XP_006256284.1	FKBP_C	61..152	CDD:278674	28/97 (29%)
		TPR_11	284..364	CDD:290150	18/91 (20%)
		TPR repeat	285..313	CDD:276809	5/27 (19%)
		TPR_11	336..399	CDD:290150	17/62 (27%)
		TPR	336..367	CDD:197478	8/30 (27%)
		TPR repeat	336..362	CDD:276809	7/25 (28%)
		TPR repeat	367..397	CDD:276809	9/29 (31%)
		TPR_1	369..401	CDD:278916	9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810