DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zda and Fkbp15

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_006538097.1	Gene:	Fkbp15 / 338355	MGIID:	2444782	Length:	1255	Species:	Mus musculus

Alignment Length:	475	Identity:	96/475 - (20%)
Similarity:	168/475 - (35%)	Gaps:	150/475 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSSSSSFEDLT---NAEDTKDIRKVAAEEAASGDG----APPASVSGDGQKAEEEDAEEECDIL- 61
            ||:|.| |.||   |.:..|  .|:.:..|..|..    .||...|.|   :|.|||    .:|
Mouse   341 KSNSLS-EQLTVNSNPDTVK--AKLISRMAKMGQPMLPILPPQLDSND---SETEDA----TVLR 395

  Fly    62 -GNKQLIKRTIK---------------KAPQDS---FRRPIRGELVTVNFTGKLDNGTVVE-NEL 106
             ..:.|:..:|:               :|||.|   .:.|....:..|:    ||:.:.|. |..
Mouse   396 GAGQSLVTPSIQPSLQPAHPVLPQMASQAPQPSGSGLQTPSAALMQAVS----LDSHSAVSGNAQ 456

  Fly   107 NFQCHVG--------DYEVIQGLDMVLPM-------------------LQVGEVSQVSVDSRFGY 144
            |||.:.|        ...|...|..|.|:                   ..:.|..|.:.:.|...
Mouse   457 NFQPYAGVQAYAYPQTPSVTSQLQPVRPLYPAPLSQAPHFQGSGDMMSFLMTEARQHNTEIRMAV 521

  Fly   145 GSLG------------LKKEGESEYLVPPDAHLTYEIELL--DIK--YEEFADLKSFEILRKYGT 193
            ..:.            |:|......::.|...:|.|..::  :|:  .:|...||. |:|.| .:
Mouse   522 NKVADKMDHLMTKVEELQKHSSGNSMLLPSMSVTMETSMIMSNIQRIIQENERLKQ-ELLEK-SS 584

  Fly   194 RKKERANFFYKRSEFTTAIHLYRRALD----FLDNRDGDPDSEFDKEDLELSNSDTQTLL----E 250
            |.:|      :..:.:..|...:|.::    .::.|:         ..|:.:..:||..:    :
Mouse   585 RIEE------QNDKISDLIERNQRYVEQSNLMMEKRN---------NSLQTATENTQARILHAEQ 634

  Fly   251 DRLIVYNNLAMT-------QIKIAAY-----DAALQSVE----------HVLRCQPNNSKALYRK 293
            ::..|...||..       |:|:.|:     :..||..:          ||.|.|.:.|:
Mouse   635 EKAKVTEELAAATAQVSHLQLKMTAHQKKETELQLQLTDNLKETDLLRGHVTRLQADLSE----- 694

  Fly   294 GRILEGKADTQGAIK--------LLQKVATLEPE---NRAVQSDLARLFIKARREEHNEKEMYQK 347
              :.|....||...|        |..||.:||.|   .||.::.|.:...:.:::...|:...:.
Mouse   695 --LREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKTSLEKNLSERKKKSAQERCQAEA 757

  Fly   348 MLGQAKKMEQNTATRQKQPL 367
            .:.:.:|..|....|.:|.|
Mouse   758 EMDEIRKSHQEELDRLRQLL 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	22/131 (17%)
		TPR_11	196..284	CDD:290150	18/117 (15%)
		TPR repeat	196..220	CDD:276809	3/23 (13%)
		TPR repeat	252..282	CDD:276809	10/51 (20%)
		TPR_11	255..318	CDD:290150	21/92 (23%)
		TPR repeat	287..313	CDD:276809	6/33 (18%)
		TPR repeat	321..349	CDD:276809	4/27 (15%)
Fkbp15	XP_006538097.1	FKBP_C	192..285	CDD:365980
		PRK10263	<378..>489	CDD:236669	29/121 (24%)
		Smc	<561..890	CDD:224117	47/241 (20%)
		PHA03247	<944..1129	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900