DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zda and Fkbp6

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001099392.1	Gene:	Fkbp6 / 288597	RGDID:	1308926	Length:	327	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	79/335 - (23%)
Similarity:	151/335 - (45%)	Gaps:	50/335 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DGAPPASVSGDGQKAEEEDAEEECDILGNKQLIKRTIKKAPQDSFRRPIRGEL-VTVNFTGKLDN 98
            :|.||:  ..|.|...|..::...||.|::.::|..|::...|    |:..:. |.|.::|.|::
  Rat     9 NGIPPS--RDDCQSPYERLSQRMLDISGDRGVLKDIIREGAGD----PVTPDASVLVKYSGYLEH 67

  Fly    99 GTVVENELNFQC--------HVGDYEVIQGLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGES 155
               ::...:..|        .:|:...:.|:::.|..::.||:::......:.||:||...
  Rat    68 ---MDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPTYAYGTLGCPP---- 125

  Fly   156 EYLVPPDAHLTYEIELLDI----KYEEFADLKS-------FEILRKYGTRKKERANFFYKRSEFT 209
              |:||:|.:.:||||:|.    :.::|..|.:       .:.:.|....::|..|:.::::.|.
  Rat   126 --LIPPNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFC 188

  Fly   210 TAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLED-RLIVYNNLAMTQIKIAAYDAAL 273
            .|...|:|||..|..|              |:..:.|.|:|. .|:|..||:...:|:.....||
  Rat   189 DAKVRYKRALLLLHRR--------------LAICEEQHLVEPAELLVLLNLSFVYLKLDRPAMAL 239

  Fly   274 QSVEHVLRCQPNNSKALYRKGRILEGKADTQGAIKLLQKVATLEPENRAVQSDLARLFIKARREE 338
            :..|..|.....|:|||:|.|:......:.:.|...|.:....:|.|..:.::|.:|....|...
  Rat   240 RYGEQALLIDKRNAKALFRCGQACLLLTEYEQARDFLVRAQKEQPCNHDINNELKKLSSHYRDYV 304

  Fly   339 HNEKEMYQKM 348
            ..|:||..:|
  Rat   305 DREREMCHRM 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	22/100 (22%)
		TPR_11	196..284	CDD:290150	23/88 (26%)
		TPR repeat	196..220	CDD:276809	7/23 (30%)
		TPR repeat	252..282	CDD:276809	9/29 (31%)
		TPR_11	255..318	CDD:290150	16/62 (26%)
		TPR repeat	287..313	CDD:276809	7/25 (28%)
		TPR repeat	321..349	CDD:276809	7/28 (25%)
Fkbp6	NP_001099392.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/12 (33%)
		FKBP_C	51..140	CDD:395196	21/97 (22%)
		TPR	<164..284	CDD:223533	32/133 (24%)
		TPR 1	171..204		9/32 (28%)
		TPR repeat	218..248	CDD:276809	9/29 (31%)
		TPR 2	219..252		9/32 (28%)
		TPR 3	253..286		8/32 (25%)
		TPR repeat	253..281	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810