DRSC/TRiP Functional Genomics Resources

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Protein Alignment zda and Fkbp4

DIOPT Version :10

Sequence 1:NP_611353.1 Gene:zda / 37144 FlyBaseID:FBgn0034368 Length:397 Species:Drosophila melanogaster
Sequence 2:NP_001178792.1 Gene:Fkbp4 / 260321 RGDID:628729 Length:458 Species:Rattus norvegicus


Alignment Length:354 Identity:94/354 - (26%)
Similarity:157/354 - (44%) Gaps:57/354 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EEAASGDGAPP-----ASVSGDGQKAE--EEDAEEECDILGNKQLIKRTIKKAPQDSFRRPIRGE 86
            |.|....|:||     |::..:.:..|  .||..|:.|  |.  :|:|.  :...:.:.||..|.
  Rat   110 EYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEDED--GG--IIRRI--RTRGEGYARPNDGA 168

  Fly    87 LVTVNFTGKLDNGTVVENELNFQCHVGDYEVIQ---GLDMVLPMLQVGEVSQVSVDSRFGYGSLG 148
            :|.|...|..::....:.||.|:  ||:.|.:.   ||:..:..::.||.|.|.:...:.:||: 
  Rat   169 MVEVALEGYYNDRLFDQRELCFE--VGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSV- 230

  Fly   149 LKKEGESEYLVPPDAHLTYEIELLDIKYEEFADLKSFEILR-----------KYGTRKKERANFF 202
                |:..:.:||.|.|.||:.           |||||..:           :.....|||...:
  Rat   231 ----GKERFQIPPHAELRYEVH-----------LKSFEKAKASWEMNSEEKLEQSNIVKERGTVY 280

  Fly   203 YKRSEFTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLEDRLIVYNNLAMTQIKIA 267
            :|..::..|:..|::.:.:|:.     :|.|..|::       |.:...||..:.||||..:|:.
  Rat   281 FKEGKYKQALLQYKKIVSWLEY-----ESSFSGEEM-------QKVHALRLASHLNLAMCHLKLQ 333

  Fly   268 AYDAALQSVEHVLRCQPNNSKALYRKGRILEGKADTQGAIKLLQKVATLEPENRAVQSDLARLFI 332
            |:.||::|....|....||.|.|:|:|.......|...|....|||..|.|.|:|.::.||....
  Rat   334 AFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQ 398

  Fly   333 KARREEHNEKEMYQKMLGQAKKMEQNTAT 361
            :.||:...||::|..|..:..:.|....|
  Rat   399 RTRRQLAREKKLYANMFERLAEEEHKAKT 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zdaNP_611353.1 FKBP_C 80..172 CDD:459735 27/94 (29%)
Spy 196..>338 CDD:443119 42/141 (30%)
TPR repeat 196..220 CDD:276809 6/23 (26%)
TPR repeat 252..282 CDD:276809 12/29 (41%)
TPR repeat 287..313 CDD:276809 7/25 (28%)
TPR repeat 321..349 CDD:276809 8/27 (30%)
Fkbp4NP_001178792.1 FKBP_C 43..134 CDD:459735 6/23 (26%)
Interaction with tubulin 267..400 40/144 (28%)
TPR repeat 274..301 CDD:276809 6/26 (23%)
NlpI <275..424 CDD:443815 46/160 (29%)
TPR repeat 306..348 CDD:276809 15/48 (31%)
TPR repeat 353..381 CDD:276809 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..458 1/5 (20%)

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