Protein Alignment zda and FKBP8

DIOPT Version :10

• Sequence 1: NP_611353.1
• Gene: zda / 37144
• FlyBaseID: FBgn0034368
• Length: 397
• Species: Drosophila melanogaster
• Sequence 2: NP_036313.3
• Gene: FKBP8 / 23770
• HGNCID: 3724
• Length: 413
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 128/423 - (30%)
• Similarity: 197/423 - (46%)
• Gaps: 82/423 - (19%)

  Fly    11 FEDLTNAEDTKDIRKVAAEEAASGD----------GAPPASVSGDGQKAEEEDA----------- 54
            ||.|...||.:...:...||....|          |.|||      ::||:..|
Human    24 FEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPA------EEAEQPGALAREFLAAMEP 82

  Fly    55 --------EEECDILGNKQLIKRTIKKAPQDSFRRPIRGELVTVNFTGKLDNGTVVENELNFQCH 111
                    ||..|||||..|.|:|:...|..| .||::|::|||:....|:|||.|:.|......
Human    83 EPAPAPAPEEWLDILGNGLLRKKTLVPGPPGS-SRPVKGQVVTVHLQTSLENGTRVQEEPELVFT 146

  Fly   112 VGDYEVIQGLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKY 176
            :||.:|||.||:.:|::.|||.:.|:.||::.||..|    ..|.| :||.|.|..|:.|
Human   147 LGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQG----SRSPY-IPPHAALCLEVTL----- 201

  Fly   177 EEFADLKSFEILR-----KYGTRKKERANFFYKRSEFTTAIHLYRRALDFLDNRDGDPDSEFDKE 236
            :...|....|:|.     ....||:|..|..|:|::|..|.:.|..|:..:.: ....|..|::|
Human   202 KTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITS-SAKVDMTFEEE 265

  Fly   237 DLELSNSDTQTLLEDRLIVYNNLAMTQIKIAAYDAALQSVEHVLRCQPNNSKALYRKGRILEGKA 301
                     ..||:.::...||||.:|:|:..|.|||:|...||..||:|.|||:|||::|..:.
Human   266 ---------AQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQG 321

  Fly   302 DTQGAIKLLQKVATLEPENRAVQSDLARLFIKARREEHNEKEMYQKMLGQAKKMEQNTATRQKQP 366
            :...||.:|:....|||.|:.:.::|::|..|...:...|..:|:||||...::.
Human   322 EYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLP---------- 376

  Fly   367 LVDNSKLKLLG-------YLMGTILIGVAGVAI 392
                :|....|       :|.|...:.:.|||:
Human   377 ----AKCPGKGAWSIPWKWLFGATAVALGGVAL 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_611353.1	FKBP_C	80..172	CDD:459735	36/91 (40%)
		Spy	196..>338	CDD:443119	46/141 (33%)
		TPR repeat	196..220	CDD:276809	8/23 (35%)
		TPR repeat	252..282	CDD:276809	13/29 (45%)
		TPR repeat	287..313	CDD:276809	10/25 (40%)
		TPR repeat	321..349	CDD:276809	6/27 (22%)
FKBP8	NP_036313.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		13/49 (27%)
		FKBP_C	113..202	CDD:459735	38/99 (38%)
		TPR	220..>347	CDD:440225	45/136 (33%)
		TPR 1	222..255		10/33 (30%)
		TPR repeat	231..267	CDD:276809	9/45 (20%)
		TPR repeat	272..302	CDD:276809	13/29 (45%)
		TPR 2	273..306		15/32 (47%)
		TPR 3	307..340		13/32 (41%)
		TPR repeat	307..335	CDD:276809	10/27 (37%)
		TPR repeat	341..369	CDD:276809	6/27 (22%)