Protein Alignment zda and FKBP15

DIOPT Version :9

• Sequence 1: NP_001286579.1
• Gene: zda / 37144
• FlyBaseID: FBgn0034368
• Length: 397
• Species: Drosophila melanogaster
• Sequence 2: NP_056073.1
• Gene: FKBP15 / 23307
• HGNCID: 23397
• Length: 1219
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 72/363 - (19%)
• Similarity: 125/363 - (34%)
• Gaps: 115/363 - (31%)

  Fly     2 DTEKSSSSSFEDLTNAEDTKDIRKVAAEEAAS-GDGAPPASVSGDGQKAEEEDAEEECDILGNKQ 65
            :.||..|||.|:...||:..  |:.:.|::|| ..|.|.|.::.:         ..|..::.::|
Human   933 EQEKEESSSEEEEEKAEERP--RRPSQEQSASASSGQPQAPLNRE---------RPESPMVPSEQ 986

  Fly    66 LIKRTIKKAP------QDSFRRPIRGELVTVNFTGKLDNGTVVENELNFQCHVGDYEVIQGLDMV 124
            :::..:...|      ||..||....|...::   ::.:|: :..||:  | :..:.|: |....
Human   987 VVEEAVPLPPQALTTSQDGHRRKGDSEAEALS---EIKDGS-LPPELS--C-IPSHRVL-GPPTS 1043

  Fly   125 LPMLQVGEVSQVS-VDSRFGYGSLGLKKEGESEYL----VPPDAHLTYEIELLDIKYEEFADLKS 184
            :|...:|.||..| .:.......:..|.:..|..:    |.||..|
Human  1044 IPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPL------------------- 1089

  Fly   185 FEILRKYGTRKKERANFFYKRSEFTTAIHLYRRALDFLDNRDGD-----PDSEFDKEDLELSNSD 244
                                 .|.:|.:.|..      |..:||     |:|..:.:..:|...|
Human  1090 ---------------------QESSTRLSLTS------DPEEGDPLALGPESPGEPQPPQLKKDD 1127

  Fly   245 TQTLLEDRLIVYNNLAMTQIKIAAYDAALQSVEHVLRCQPNNSKALYRKGRILEGKADTQGAIKL 309
            ..:....    :..|:.|:.......|||:...|..|..             |.|..:.:
Human  1128 VTSSTGP----HKELSSTEAGSTVAGAALRPSHHSQRSS-------------LSGDEEDE----- 1170

  Fly   310 LQKVATLEPENRAVQSDLARLFIKARREEHNEKEMYQK 347
            |.|.|||:           .|..||:.||.:|.|:..|
Human  1171 LFKGATLK-----------ALRPKAQPEEEDEDEVSMK 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	20/96 (21%)
		TPR_11	196..284	CDD:290150	17/92 (18%)
		TPR repeat	196..220	CDD:276809	3/23 (13%)
		TPR repeat	252..282	CDD:276809	6/29 (21%)
		TPR_11	255..318	CDD:290150	14/62 (23%)
		TPR repeat	287..313	CDD:276809	3/25 (12%)
		TPR repeat	321..349	CDD:276809	8/27 (30%)
FKBP15	NP_056073.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..66
		PH-like	70..168	CDD:302622
		Important for function in growth cone organization. /evidence=ECO:0000250	72..169
		FKBP_C	193..286	CDD:278674
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..349
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..433
		COG1340	511..781	CDD:224259
		TIMELESS_C	589..>777	CDD:252956
		SPEC	686..908	CDD:295325
		DUF4515	694..871	CDD:291649
		Ax_dynein_light	<715..780	CDD:287215
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..761
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..1219		72/363 (20%)
		Extradiol_Dioxygenase_3B_like	<1014..>1072	CDD:294399	12/65 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900