DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zda and FKBP5

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001139247.1	Gene:	FKBP5 / 2289	HGNCID:	3721	Length:	457	Species:	Homo sapiens

Alignment Length:	332	Identity:	80/332 - (24%)
Similarity:	141/332 - (42%)	Gaps:	66/332 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DILGNKQLIKRTIKKAPQDSFRRPIRGELVTVNFTGKLDNG---------TVVENELNFQCHVGD 114
            |:..:..:|:||.:|.  :.:..|..|..|.::..|:....         ||.|.|        |
Human   141 DLFEDGGIIRRTKRKG--EGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGE--------D 195

  Fly   115 YEVIQGLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKYEEF 179
            :::..|:|..|..:|..|...:.:..|:|:|..|..|.|     :.|:|.|.||:
Human   196 HDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFG-----IEPNAELIYEV---------- 245

  Fly   180 ADLKSFEILR---KYGTRK--------KERANFFYKRSEFTTAIHLYRRALDFLDNRDGDPDSEF 233
             .|||||..:   :..|::        ||:...::|..::..|:..|.:.:.:|:...|
Human   246 -TLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYG------ 303

  Fly   234 DKEDLELSNSDTQTLLEDRLIVYNNLAMTQIKIAAYDAALQSVEHVLRCQPNNSKALYRKGRILE 298
                  ||..:::......|..:.||||..:|:..|..|::..:..|.....|.|.|||:|....
Human   304 ------LSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQL 362

  Fly   299 GKADTQGAIKLLQKVATLEPENRAVQSDLARLFIKARREEHNEKE------MYQKMLGQAKKMEQ 357
            ...:.:.|....:||..:.|:|:|.:..::....||:  ||||::      |::|...|..|.|.
Human   363 LMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAK--EHNERDRRIYANMFKKFAEQDAKEEA 425

  Fly   358 NTATRQK 364
            |.|..:|
Human   426 NKAMGKK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	25/100 (25%)
		TPR_11	196..284	CDD:290150	18/87 (21%)
		TPR repeat	196..220	CDD:276809	5/23 (22%)
		TPR repeat	252..282	CDD:276809	9/29 (31%)
		TPR_11	255..318	CDD:290150	17/62 (27%)
		TPR repeat	287..313	CDD:276809	6/25 (24%)
		TPR repeat	321..349	CDD:276809	9/33 (27%)
FKBP5	NP_001139247.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		FKBP_C	43..135	CDD:278674
		TPR_11	267..347	CDD:290150	18/91 (20%)
		TPR 1	268..301		6/32 (19%)
		TPR repeat	268..296	CDD:276809	5/27 (19%)
		TPR 2	317..350		9/32 (28%)
		TPR_11	319..382	CDD:290150	17/62 (27%)
		TPR	319..350	CDD:197478	8/30 (27%)
		TPR repeat	319..345	CDD:276809	7/25 (28%)
		TPR repeat	350..380	CDD:276809	9/29 (31%)
		TPR 3	351..384		9/32 (28%)
		TPR_1	352..384	CDD:278916	9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..457		5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810