DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zda and Fkbp10

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_034351.2	Gene:	Fkbp10 / 14230	MGIID:	104769	Length:	581	Species:	Mus musculus

Alignment Length:	262	Identity:	58/262 - (22%)
Similarity:	100/262 - (38%)	Gaps:	60/262 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VAAEEAASGDGAPPASV-SGDGQKAEEEDAEEECDILGNKQLIKRTIKKAPQDSFRRPIRGELVT 89
            :|..|..:||..|.::| ..|....:..:..:..:|        :|:.:.|::.......|:.:.
Mouse   346 LAYGENGTGDKIPGSAVLIFDVHVIDFHNPSDPVEI--------KTLSRPPENCNETSKIGDFIR 402

  Fly    90 VNFTGKLDNGTVVENELNFQCHVGDYE-----------VIQGLDMVLPMLQVGEVSQVSVDSRFG 143
            .::...|.:||.:     |..|  |||           ||:|||..|..:.|||..|:.|.....
Mouse   403 YHYNCSLLDGTRL-----FSSH--DYEAPQEITLGANKVIEGLDRGLQGMCVGERRQLIVPPHLA 460

  Fly   144 YGSLGLKKEGESEYLVPPDAHLTYEIEL-----------LDIKYEE-----FADLKSFEILRKYG 192
            :|..|.:.       ||..|.|.:|:||           |.:.|::     |.|:.    |.|.|
Mouse   461 HGENGARG-------VPGSAVLLFEVELVSREDGLPTGYLFVWYQDPSTSLFEDMD----LNKDG 514

  Fly   193 TRKKERANFFYK------RSEFTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLED 251
            ....|..:.|.|      :..........:...|...|:|.:.|.:...|:|:|.:.:.|..:.:
Mouse   515 EVPPEEFSSFIKAQVNEGKGRLMPGQDPDKTISDMFQNQDRNQDGKITAEELKLKSDEDQERVHE 579

  Fly   252 RL 253
            .|
Mouse   580 EL 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	29/113 (26%)
		TPR_11	196..284	CDD:290150	12/64 (19%)
		TPR repeat	196..220	CDD:276809	3/29 (10%)
		TPR repeat	252..282	CDD:276809	1/2 (50%)
		TPR_11	255..318	CDD:290150
		TPR repeat	287..313	CDD:276809
		TPR repeat	321..349	CDD:276809
Fkbp10	NP_034351.2	FKBP_C	54..146	CDD:278674
		FKBP_C	166..258	CDD:278674
		FKBP_C	278..370	CDD:278674	7/23 (30%)
		FKBP_C	391..482	CDD:278674	28/104 (27%)
		EF-hand_7	504..567	CDD:290234	13/66 (20%)
		EFh	505..566	CDD:238008	13/64 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..581		8/47 (17%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	578..581		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810