DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zda and Fkbp5

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_034350.1	Gene:	Fkbp5 / 14229	MGIID:	104670	Length:	456	Species:	Mus musculus

Alignment Length:	331	Identity:	83/331 - (25%)
Similarity:	143/331 - (43%)	Gaps:	64/331 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DILGNKQLIKRTIKKAPQDSFRRPIRGELVTVNFTGKLDNGTVVENELNFQCH-----VG---DY 115
            |:..:..:|:|..:|.  :.:..|..|..|.|:..|.....|       |.|.     ||   |:
Mouse   141 DLFEDSGVIRRIKRKG--EGYSNPNEGATVKVHLEGCCGGRT-------FDCRDVVFVVGEGEDH 196

  Fly   116 EVIQGLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKYEEFA 180
            ::..|:|..|..:|..|...:.:..|:|:|..|..|.|     :.|:|.|.||:
Mouse   197 DIPIGIDKALVKMQREEQCILYLGPRYGFGEAGKPKFG-----IDPNAELMYEV----------- 245

  Fly   181 DLKSFEILR---KYGTRK--------KERANFFYKRSEFTTAIHLYRRALDFLDNRDGDPDSEFD 234
            .|||||..:   :..|::        ||:...::|..::|.|:..||:.:.:|:...|
Mouse   246 TLKSFEKAKESWEMDTKEKLTQAAIVKEKGTVYFKGGKYTQAVIQYRKIVSWLEMEYG------- 303

  Fly   235 KEDLELSNSDTQTLLEDRLIVYNNLAMTQIKIAAYDAALQSVEHVLRCQPNNSKALYRKGRILEG 299
                 ||..:::......|..:.||||..:|:..|:.|::..:..|.....|.|.|||:|.....
Mouse   304 -----LSEKESKASESFLLAAFLNLAMCYLKLREYNKAVECCDKALGLDSANEKGLYRRGEAQLL 363

  Fly   300 KADTQGAIKLLQKVATLEPENRAVQSDLARLFIKARREEHNEKE------MYQKMLGQAKKMEQN 358
            ..|.:.|....:||..:.|:|||.:..::....||:  ||||::      |::|...:..|.|.:
Mouse   364 MNDFESAKGDFEKVLAVNPQNRAARLQISMCQRKAK--EHNERDRRVYANMFKKFAERDAKEEAS 426

  Fly   359 TATRQK 364
            .|..:|
Mouse   427 KAGSKK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	27/99 (27%)
		TPR_11	196..284	CDD:290150	20/87 (23%)
		TPR repeat	196..220	CDD:276809	7/23 (30%)
		TPR repeat	252..282	CDD:276809	9/29 (31%)
		TPR_11	255..318	CDD:290150	18/62 (29%)
		TPR repeat	287..313	CDD:276809	7/25 (28%)
		TPR repeat	321..349	CDD:276809	10/33 (30%)
Fkbp5	NP_034350.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		FKBP_C	44..135	CDD:278674
		TPR_11	267..347	CDD:290150	20/91 (22%)
		TPR 1	268..301		8/32 (25%)
		TPR repeat	268..296	CDD:276809	7/27 (26%)
		TPR 2	317..350		9/32 (28%)
		TPR_11	319..382	CDD:290150	18/62 (29%)
		TPR	319..350	CDD:197478	8/30 (27%)
		TPR repeat	319..345	CDD:276809	7/25 (28%)
		TPR repeat	350..380	CDD:276809	10/29 (34%)
		TPR 3	351..384		10/32 (31%)
		TPR_1	352..384	CDD:278916	10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..456		4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810