DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zda and fkbp8

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001120570.1	Gene:	fkbp8 / 100145724	XenbaseID:	XB-GENE-958351	Length:	408	Species:	Xenopus tropicalis

Alignment Length:	388	Identity:	119/388 - (30%)
Similarity:	209/388 - (53%)	Gaps:	28/388 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSSSFEDLTNAEDTKDIRKVAAEEAASGDGAPPASVSGDGQKAEEEDAEEECDILGNKQLIKRTI 71
            |:..||.:.:|.:..|:..:...|.......|.|....:.|:...::.||..|:||| .::|:.|
Frog    39 STEDFEIIDSAVEEDDLSDLPLLEDVDKKEKPAADNDLNTQQTVAKEEEEWLDVLGN-GILKKKI 102

  Fly    72 KKAPQDSFRRPIRGELVTVNFTGKLDNGTVVENELNFQCHVGDYEVIQGLDMVLPMLQVGEVSQV 136
            ..:.:.:..||.:|:.|||.....|::|.|||.:......:||.:|||.||:.:.:::..|.|.:
Frog   103 LISGKGADSRPRKGQDVTVGLKSMLEDGNVVEEQETLTFTLGDGDVIQALDLCVQLMEAEETSLI 167

  Fly   137 SVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKYEEFADLKSFEILRK--YGTRKKERA 199
            :.|:::.||     |||.|.. :||:::|..|:.|||:  ::..||::.....|  ...:|:||.
Frog   168 ASDAKYCYG-----KEGRSPD-IPPNSNLNLEVALLDV--QDGPDLENLSGQEKLNLANKKRERG 224

  Fly   200 NFFYKRSEFTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLEDRLIVYNNLAMTQI 264
            ||:|:::::..||:.|..||:.:::          ...:|.|..:..:||:.::...||||.:|:
Frog   225 NFYYQQADYVFAINSYDIALNVVNS----------SSKVEFSLEEEASLLDVKIKCLNNLAASQL 279

  Fly   265 KIAAYDAALQSVEHVLRCQPNNSKALYRKGRILEGKADTQGAIKLLQKVATLEPENRAVQSDLAR 329
            |:..|:|||:|...||..||.|.|||:|||::|..:.:...||.:|:|...|||.|:.:.::|:|
Frog   280 KLDHYEAALKSCNMVLEHQPENIKALFRKGKVLAQQGEYSDAITILRKALKLEPANKTIHAELSR 344

  Fly   330 LFIKARREEHNEKEMYQKMLGQAKKMEQNTATRQKQPLVDNSKLKLLGYLMGTILIGVAGVAI 392
            |..|...:.:.|..||:||||       |..:...:|...:|......:|.|...:.:.|||:
Frog   345 LVKKHTDQRNVESAMYKKMLG-------NPGSASTKPASKSSWSIPWKWLFGATAVAIGGVAL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	31/91 (34%)
		TPR_11	196..284	CDD:290150	27/87 (31%)
		TPR repeat	196..220	CDD:276809	9/23 (39%)
		TPR repeat	252..282	CDD:276809	13/29 (45%)
		TPR_11	255..318	CDD:290150	28/62 (45%)
		TPR repeat	287..313	CDD:276809	10/25 (40%)
		TPR repeat	321..349	CDD:276809	8/27 (30%)
fkbp8	NP_001120570.1	FkpA	2..199	CDD:223619	50/166 (30%)
		FKBP_C	110..197	CDD:365980	31/92 (34%)
		TPR	<211..333	CDD:223533	44/131 (34%)
		TPR repeat	217..262	CDD:276809	13/54 (24%)
		TPR repeat	267..297	CDD:276809	13/29 (45%)
		TPR repeat	302..330	CDD:276809	11/27 (41%)
		TPR repeat	336..364	CDD:276809	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10709
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7720
Inparanoid	1	1.050	181	1.000	Inparanoid score	I3864
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248966at33208
OrthoFinder	1	1.000	-	-		FOG0006509
OrthoInspector	1	1.000	-	-		otm49314
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090