DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip55E and cth

DIOPT Version :9

Sequence 1:	NP_001286578.1	Gene:	Eip55E / 37143	FlyBaseID:	FBgn0000566	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_997769.3	Gene:	cth / 322055	ZFINID:	ZDB-GENE-030131-774	Length:	404	Species:	Danio rerio

Alignment Length:	381	Identity:	233/381 - (61%)
Similarity:	295/381 - (77%)	Gaps:	0/381 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FATKSIHSGQSPDQWKSAAVIPPISLSTTFKQDAPGEHRGYEYSRSGNPTRNVLETCFAALDNAK 74
            |||.:||.|..|:||.|.||:|||||||||||..||:|.|:|||||||||||.||...||||.||
Zfish    20 FATDAIHVGSEPEQWSSMAVVPPISLSTTFKQHGPGKHAGFEYSRSGNPTRNCLEKAVAALDGAK 84

  Fly    75 YGLTFSSGLGATTAVLTMLSSGDHIIMGDDVYGGTNRLIRQVATRLGISATFVDPTKLDLIKSSI 139
            |.|..:|||.||..:..:..|||.|:..:||||||||..|:||:.:|:..:|.|.|||:.:|:.:
Zfish    85 YCLAVASGLAATLTITHLFKSGDGILCMNDVYGGTNRYFRKVASEVGLDISFADLTKLEELKAGL 149

  Fly   140 KPETKLVWIESPTNPLVKVADIEAIAQLVHGVREDIVLAVDNTFLTSYFQRPLELGADLVCYSLT 204
            ||.||:||||:||||.:||.||:|.|.:||...:|.::.|||||:::||||||.||||:..||.|
Zfish   150 KPNTKMVWIETPTNPTMKVVDIQACADIVHKHNKDTIVVVDNTFMSAYFQRPLALGADICMYSAT 214

  Fly   205 KYMNGHTDVVMGGITMNSEKLYKSLKFLQNAVGIVPSPFDCYQVNRSLKTLSLRMEQHQKNALKV 269
            ||||||:|||||.|:::.:.||:.||||||::|.||||||||..||.||||.|||:||.||||..
Zfish   215 KYMNGHSDVVMGLISLSRDDLYERLKFLQNSLGAVPSPFDCYMCNRGLKTLHLRMKQHFKNALAA 279

  Fly   270 AKYLETNPFVEKVLHPSLPSHPQHKIALKQAYGYSGVFSFYIKGELKHSSAFLKALKVFTLAESL 334
            |::||.:|.|::|:.|.|||||||::..:|..|..|:.:|||||:|:|:|.||..||:|.|||||
Zfish   280 AQFLEADPRVDRVIFPGLPSHPQHELTKRQCTGCPGMITFYIKGKLEHASTFLSNLKLFALAESL 344

  Fly   335 GGYESLAELPSIMTHASVPAEDRKTLGITDGLVRLSVGLEDADDLIKDLEQALEIA 390
            ||||||||.|:|||||||..|:||.|||:|.|:||||||||.:|:|.||:|||..|
Zfish   345 GGYESLAEHPAIMTHASVCEEERKKLGISDTLIRLSVGLEDEEDIIADLDQALGAA 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip55E	NP_001286578.1	PRK08776	7..393	CDD:181554	233/381 (61%)
Eip55E	NP_001286578.1	Cys_Met_Meta_PP	11..388	CDD:279402	230/376 (61%)
cth	NP_997769.3	PRK08776	19..400	CDD:181554	232/379 (61%)
cth	NP_997769.3	Cys_Met_Meta_PP	21..397	CDD:279402	229/375 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583660
Domainoid	1	1.000	478	1.000	Domainoid score	I402
eggNOG	1	0.900	-	-		E1_COG0626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1432
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1417
OMA	1	1.010	-	-		QHG62407
OrthoDB	1	1.010	-	-		D311972at33208
OrthoFinder	1	1.000	-	-		FOG0002609
OrthoInspector	1	1.000	-	-		otm24469
orthoMCL	1	0.900	-	-		OOG6_100353
Panther	1	1.100	-	-	LDO	PTHR11808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R285
SonicParanoid	1	1.000	-	-		X1714
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800