DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip55E and cth-2

DIOPT Version :9

Sequence 1:	NP_001286578.1	Gene:	Eip55E / 37143	FlyBaseID:	FBgn0000566	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_495449.1	Gene:	cth-2 / 174155	WormBaseID:	WBGene00022856	Length:	392	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	231/382 - (60%)
Similarity:	294/382 - (76%)	Gaps:	1/382 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FATKSIHSGQSPDQWKSAAVIPPISLSTTFKQDAPGEHRGYEYSRSGNPTRNVLETCFAALDNAK 74
            |.|.:||.||.|:||....|:||||||:|:|||.|||.:|::|||:|||||:||:...|||::||
Worm     7 FGTAAIHVGQEPEQWDMNQVVPPISLSSTYKQDNPGEPKGHDYSRAGNPTRDVLQKNLAALEDAK 71

  Fly    75 YGLTFSSGLGATTAVLTMLSSGDHIIMGDDVYGGTNRLIRQVAT-RLGISATFVDPTKLDLIKSS 138
            :...|||||.||:|::.:|..||||:..|||||||.|.||:||. ..|:....||.|.:..::.:
Worm    72 HCQVFSSGLAATSAIINLLKYGDHIVCSDDVYGGTQRYIRRVAVPNHGLEVDSVDLTDVQNLEKA 136

  Fly   139 IKPETKLVWIESPTNPLVKVADIEAIAQLVHGVREDIVLAVDNTFLTSYFQRPLELGADLVCYSL 203
            |||.||:||.|||:|||:||.||.|:.|.......:||:.|||||::.|||||:.||||:|.:|:
Worm   137 IKPNTKMVWFESPSNPLLKVVDIAAVVQTAKKANPEIVVVVDNTFMSPYFQRPISLGADVVVHSI 201

  Fly   204 TKYMNGHTDVVMGGITMNSEKLYKSLKFLQNAVGIVPSPFDCYQVNRSLKTLSLRMEQHQKNALK 268
            |||:|||:|||||.:..::::..:.|.|:|.|||.|||||||:.|||.||||.:||..|.:|||.
Worm   202 TKYINGHSDVVMGAVITDNDEFQQHLFFMQLAVGAVPSPFDCFLVNRGLKTLHIRMRAHYENALA 266

  Fly   269 VAKYLETNPFVEKVLHPSLPSHPQHKIALKQAYGYSGVFSFYIKGELKHSSAFLKALKVFTLAES 333
            ||||||.|..:|.||:|:|||||||::..||..|.||:.|||:||||:.|.|||.||||||||||
Worm   267 VAKYLEANDRIESVLYPALPSHPQHEVHEKQTKGMSGMISFYLKGELQESRAFLSALKVFTLAES 331

  Fly   334 LGGYESLAELPSIMTHASVPAEDRKTLGITDGLVRLSVGLEDADDLIKDLEQALEIA 390
            ||||||||||||||||||||||.|..|||||.|:|:|||:||.|||:.||:|||:||
Worm   332 LGGYESLAELPSIMTHASVPAETRIVLGITDNLIRISVGIEDLDDLVADLDQALKIA 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip55E	NP_001286578.1	PRK08776	7..393	CDD:181554	231/382 (60%)
Eip55E	NP_001286578.1	Cys_Met_Meta_PP	11..388	CDD:279402	227/377 (60%)
cth-2	NP_495449.1	Cys_Met_Meta_PP	8..372	CDD:279402	218/363 (60%)
cth-2	NP_495449.1	PRK09028	9..372	CDD:181615	218/362 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161002
Domainoid	1	1.000	467	1.000	Domainoid score	I221
eggNOG	1	0.900	-	-		E1_COG0626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1432
Inparanoid	1	1.050	472	1.000	Inparanoid score	I834
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62407
OrthoDB	1	1.010	-	-		D311972at33208
OrthoFinder	1	1.000	-	-		FOG0002609
OrthoInspector	1	1.000	-	-		otm14325
orthoMCL	1	0.900	-	-		OOG6_100353
Panther	1	1.100	-	-	LDO	PTHR11808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R285
SonicParanoid	1	1.000	-	-		X1714
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840