DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip55E and CTH

DIOPT Version :9

Sequence 1:	NP_001286578.1	Gene:	Eip55E / 37143	FlyBaseID:	FBgn0000566	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001893.2	Gene:	CTH / 1491	HGNCID:	2501	Length:	405	Species:	Homo sapiens

Alignment Length:	381	Identity:	241/381 - (63%)
Similarity:	301/381 - (79%)	Gaps:	1/381 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FATKSIHSGQSPDQWKSAAVIPPISLSTTFKQDAPGEHRGYEYSRSGNPTRNVLETCFAALDNAK 74
            |||::||.||.|:||.|.||:|||||||||||.|||:|.|:|||||||||||.||...||||.||
Human    18 FATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAK 82

  Fly    75 YGLTFSSGLGATTAVLTMLSSGDHIIMGDDVYGGTNRLIRQVATRLGISATFVDPTKLDLIKSSI 139
            |.|.|:|||.||..:..:|.:||.||..|||||||||..||||:..|:..:|||.:|:.|::::|
Human    83 YCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAI 147

  Fly   140 KPETKLVWIESPTNPLVKVADIEAIAQLVHGVREDIVLAVDNTFLTSYFQRPLELGADLVCYSLT 204
            .|||||||||:||||..||.|||..|.:|| ...||:|.|||||::.||||||.||||:..||.|
Human   148 TPETKLVWIETPTNPTQKVIDIEGCAHIVH-KHGDIILVVDNTFMSPYFQRPLALGADISMYSAT 211

  Fly   205 KYMNGHTDVVMGGITMNSEKLYKSLKFLQNAVGIVPSPFDCYQVNRSLKTLSLRMEQHQKNALKV 269
            ||||||:|||||.:::|.|.|:..|:||||::|.||||.|||..||.||||.:|||:|.||.:.|
Human   212 KYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAV 276

  Fly   270 AKYLETNPFVEKVLHPSLPSHPQHKIALKQAYGYSGVFSFYIKGELKHSSAFLKALKVFTLAESL 334
            |::||:||:||||::|.|||||||::..:|..|.:|:.:|||||.|:|:..|||.||:|||||||
Human   277 AQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESL 341

  Fly   335 GGYESLAELPSIMTHASVPAEDRKTLGITDGLVRLSVGLEDADDLIKDLEQALEIA 390
            ||:|||||||:|||||||...||..|||:|.|:||||||||.:||::||:|||:.|
Human   342 GGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip55E	NP_001286578.1	PRK08776	7..393	CDD:181554	241/381 (63%)
Eip55E	NP_001286578.1	Cys_Met_Meta_PP	11..388	CDD:279402	238/376 (63%)
CTH	NP_001893.2	Cys_Met_Meta_PP	19..379	CDD:307273	227/360 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149520
Domainoid	1	1.000	490	1.000	Domainoid score	I381
eggNOG	1	0.900	-	-		E1_COG0626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1432
Inparanoid	1	1.050	494	1.000	Inparanoid score	I1406
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62407
OrthoDB	1	1.010	-	-		D311972at33208
OrthoFinder	1	1.000	-	-		FOG0002609
OrthoInspector	1	1.000	-	-		oto91003
orthoMCL	1	0.900	-	-		OOG6_100353
Panther	1	1.100	-	-	LDO	PTHR11808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R285
SonicParanoid	1	1.000	-	-		X1714
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800