DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip55E and Cth

DIOPT Version :9

Sequence 1:	NP_001286578.1	Gene:	Eip55E / 37143	FlyBaseID:	FBgn0000566	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_666065.1	Gene:	Cth / 107869	MGIID:	1339968	Length:	398	Species:	Mus musculus

Alignment Length:	381	Identity:	241/381 - (63%)
Similarity:	303/381 - (79%)	Gaps:	1/381 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FATKSIHSGQSPDQWKSAAVIPPISLSTTFKQDAPGEHRGYEYSRSGNPTRNVLETCFAALDNAK 74
            |||::||.||.|:||.|.||:.||||:||||||.||:..|:|||||||||||.||...||||.||
Mouse    17 FATQAIHVGQEPEQWNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAK 81

  Fly    75 YGLTFSSGLGATTAVLTMLSSGDHIIMGDDVYGGTNRLIRQVATRLGISATFVDPTKLDLIKSSI 139
            :.|.|:|||.||..:..:|.:||.||..|:|||||||..|:||:..|:..:|||.:|..|::::|
Mouse    82 HSLAFASGLAATITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAI 146

  Fly   140 KPETKLVWIESPTNPLVKVADIEAIAQLVHGVREDIVLAVDNTFLTSYFQRPLELGADLVCYSLT 204
            .|:|||||||:||||.:|:|||.|.||:|| .|.||:|.|||||:::||||||.||||:...|.|
Mouse   147 TPQTKLVWIETPTNPTLKLADIGACAQIVH-KRGDIILVVDNTFMSAYFQRPLALGADICMCSAT 210

  Fly   205 KYMNGHTDVVMGGITMNSEKLYKSLKFLQNAVGIVPSPFDCYQVNRSLKTLSLRMEQHQKNALKV 269
            ||||||:|||||.:::||:.|...|:||||::|.||||||||...|.||||.:|||:|.||.:.|
Mouse   211 KYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAV 275

  Fly   270 AKYLETNPFVEKVLHPSLPSHPQHKIALKQAYGYSGVFSFYIKGELKHSSAFLKALKVFTLAESL 334
            |::|||||.||||::|.|||||||::|.:|..|..|:.||||||.|:|:.||||.||:|||||||
Mouse   276 ARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESL 340

  Fly   335 GGYESLAELPSIMTHASVPAEDRKTLGITDGLVRLSVGLEDADDLIKDLEQALEIA 390
            ||||||||||:||||||||.:||.||||.|.|:||||||||..||::||::||:.|
Mouse   341 GGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip55E	NP_001286578.1	PRK08776	7..393	CDD:181554	241/381 (63%)
Eip55E	NP_001286578.1	Cys_Met_Meta_PP	11..388	CDD:279402	238/376 (63%)
Cth	NP_666065.1	PRK08776	16..396	CDD:181554	240/379 (63%)
Cth	NP_666065.1	Cys_Met_Meta_PP	18..394	CDD:279402	238/376 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839576
Domainoid	1	1.000	485	1.000	Domainoid score	I394
eggNOG	1	0.900	-	-		E1_COG0626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1432
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1399
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62407
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002609
OrthoInspector	1	1.000	-	-		oto94587
orthoMCL	1	0.900	-	-		OOG6_100353
Panther	1	1.100	-	-	LDO	PTHR11808
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R285
SonicParanoid	1	1.000	-	-		X1714
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790