DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and EXOC3L4

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_011535625.1	Gene:	EXOC3L4 / 91828	HGNCID:	20120	Length:	780	Species:	Homo sapiens

Alignment Length:	785	Identity:	147/785 - (18%)
Similarity:	282/785 - (35%)	Gaps:	163/785 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LQRPGQLEK----VEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQL-------------ET 69
            ||.|.:.|:    .:..|...:||:.:..         :.||.|:||..|             :.
Human    71 LQSPKEAEEPQTPAQGSRRTSSRKEPNAH---------RKDGTRLGLGSLRQAFSRASQRALTQV 126

  Fly    70 CMQDVREVRRRMDEVERLLR-------------GVPEVYDALEVVREENTKHSQYATAMENLKHI 121
            ..:|....||....:.|..|             ..|||...   |....::.:....|.|.||
Human   127 SKEDTGLFRRSSCSLFRSFRQALNDGPATGHSQATPEVPSG---VMNGVSQQASTGAASEELK-- 186

  Fly   122 FNVDASVQKTMALIEDDKLLNAHQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVS 186
              .:|..:....||.:.:||.|.:.|..||.     |....|..:....|.....|....|..:.
Human   187 --PEAEGKSVADLITERQLLAAFEQLLRLET-----LLVAEKASRTFEQDPTAFARRAMDVCLLY 244

  Fly   187 QELEKKLRLILSRTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPG------RPKA 245
            ..|..::..|:..||::.......:....|::..||:...           .||.      .|:.
Human   245 DGLAAEIGAIVRETLDSDGVDAAALAELARVVSAEEEAHP-----------SPPDDGDFLRTPRR 298

  Fly   246 WRRMIMDVLQQSVITRIE----GSKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFP-- 304
            ||:...:.:::|...|:.    |....| |:....|.:.|..|..::..||:.|:....|.:.
Human   299 WRQHWEEAVRRSAQERVRRPGAGWAFGE-AEGASGLAQLLAELGGLVRRDLQKVRQEVQPAYAAA 362

  Fly   305 --PHYDIFGEYVKFYHEGLSSYLDNIVRSGLEGNEYVSMMAWVTHTY--------PGVELMSHPD 359
              |.:::   |::.:|..::..|..:.|......:...::.|..:.|        ||:.|.:.|
Human   363 GFPAWEV---YLRAFHSAVAQRLQELARDARGCEQLYILLDWAANVYGSPDFLGAPGLALPAEP- 423

  Fly   360 LNVDVHRQIGTLLRPEHLKALEDEYLQNMQRNFQEWMTKAAETEKQEWFTETVPDQDEEYYHTSA 424
                    :..||.|:....||.:|...::...........:.|:..|....||:..:..|....
Human   424 --------LPPLLAPDVWARLESDYTSFLEAKIASCFDSILQLEQSHWAAAEVPEVLQGLYQAPL 480

  Fly   425 PVIIFQMIDQHLQVTNTIHQELTFKALVMSIQQVEIFGQTYLKNVI---ELKEHHFRNRDQIKYF 486
            .:.:..::.:|::....|..||....|.:..:.:.:|...:.|..:   .:.|.|
Human   481 SMDVHMLVAEHVKAAGAISAELEATTLRICTRALGLFVPRFEKAFLASEAVSEPH---------- 535

  Fly   487 THYIITIVNNSQQM-VELAQQMKQLYWPKSRTEHYEDFERLLAT----FQRIRAHAASYLLEEAF 546
               :...:|..::: ..|..:     :|.::    |:.|:.|.|    ||:       :||:...
Human   536 ---LGAYINACEELRTSLLSR-----FPGTQ----EELEKPLVTATCSFQK-------HLLQGLQ 581

  Fly   547 LDMECHFNDLFTAKWLASNIAVDTICVTLDDYFQDYNHL----RPNNFEMVINEAQKLLAKRYI- 606
            .:::..|..:.|..||..    |.:...:|.......||    ||...| .:.|..:.:.:.|:
Human   582 RELQPLFRVVCTRDWLTQ----DWLHPLMDKVVTFAGHLQRVARPRAQE-TLQEVHRFVVREYLA 641

  Fly   607 RALLSKRLSKPRAECDAITR-----KIKTEAKRFKLFFEKIAPKISLSDSPLDLIS-TLSALLSS 665
            |||      :||.....:.|     |:..:|:.....|:.:..:.:..|..:..:: .|......
Human   642 RAL------RPRERFRGMERMHGSQKMSLDAQAISDTFQGLGSEATWLDQAIQCVAEILGETYKD 700

  Fly   666 DIELLVLDLHTLLGSYPSLNEDHLVRLFYIR--NDVKAAEVREKVQDAMKSK--KAMVSIAKQDC 726
            ||:   ..|.||:.|||.:..||::.:..:|  ...:...:.:..||.:::.  .|.....:...
Human   701 DIQ---RHLETLIRSYPDIRRDHILAILALRRLGRQRNQHLLQHTQDLLRAAAGAAGAEAPRGRV 762

  Fly   727 IFKEI 731
            :|:||
Human   763 LFEEI 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	106/596 (18%)
EXOC3L4	XP_011535625.1	Sec6	238..767	CDD:283659	106/595 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5173
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391172at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850