DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and SEC6

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_012196.1	Gene:	SEC6 / 854742	SGDID:	S000001330	Length:	805	Species:	Saccharomyces cerevisiae

Alignment Length:	822	Identity:	157/822 - (19%)
Similarity:	311/822 - (37%)	Gaps:	180/822 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQLETCMQDVREVRR 79
            |:.:.::::....||:|...:.::.::|:.||..|..........|...||.|......|..:::
Yeast     6 LQQVCDLIKGDLSLERVRDIKEQLLKEKSVVEYQLNKESDKYYGEVEESLKLLNLSKNSVTSIKQ 70

  Fly    80 RMDEVERL-------LRGVPEVYDALEVVREENTKHSQY------ATAMENLKHIFNVDASVQKT 131
            :::||.:|       :.....::.|.::....||..|.|      ...||:::.:...:
Yeast    71 QINEVNKLGNDNRFAINRYDILFRATKLYETVNTTSSIYDRIYNFVALMEHIERLLVAE------ 129

  Fly   132 MALIED------DKLLNAHQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELE 190
              |.||      ..||..|..|....:.::.::. :.|:..:.|  :.|:.:.|.::..:..:.:
Yeast   130 --LAEDALETGCPHLLEIHFLLTSARDFQEQVVV-MAKEATEDA--QRTVMKLFSRLSGIISKFD 189

  Fly   191 KKL--------------------RLILSRTLNTLRKKPTIIVTALR-IIERE----EKNDQFALQ 230
            |.|                    ||.   .:..|.::..:.:.|:| ||:::    ||:....|.
Yeast   190 KLLDGLTYDIVEMARAEQISLAIRLF---KIYDLEEREDLRIEAIRNIIKKKEIEIEKSSIKKLP 251

  Fly   231 QQKVTGFLPPGRPKAW-----RRMIMDVLQQSVITR----------IEG---------SKLEER- 270
            ..|.|..|....||..     :.:..:::..::.||          |.|         .::.|:
Yeast   252 NSKNTARLQDETPKVIEYPTNKGLYQEIMSGTISTRTAPRGYKHFLINGINNSISEMFGEMREKY 316

  Fly   271 --------ADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSSYLDN 327
                    .||..|           |..:|.:||.....|.|||::||..|...|::.|.|.:.:
Yeast   317 VGDQKFDVLDNMDW-----------IFNELIIVKEHIANCCPPHWNIFEVYFDQYYKELHSLITD 370

  Fly   328 IVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVD---VHRQIGTLLRPEHLKALEDEYLQNMQ 389
            :|.|..|....:.::|:        :......|..|   ...::.:::..:..:.|..:||..:.
Yeast   371 LVESEPETIIILDILAF--------DKTFQDTLKQDFGFTKSEVKSVIGDKEKETLFKDYLNLIV 427

  Fly   390 RNFQEWMTKAAETEKQEW--FTE--TVPDQDEE-YYHTSAPVIIFQMIDQHLQVTNTIHQELTFK 449
            ....||:   ...||.|:  |.|  |.|..|.: ..........|||..|.::|....:|.   |
Yeast   428 VKMTEWI---GNLEKAEFDVFLERSTPPHSDSDGLLFLDGTKTCFQMFTQQVEVAAGTNQA---K 486

  Fly   450 ALVMSIQQVEIFGQTYLKNVI-----ELKEHHFRNRDQIKY--------------------FTHY 489
            .||..:::.........||.|     |:|:       ||.|                    ...|
Yeast   487 ILVGVVERFSDLLTKRQKNWISKISEEIKK-------QINYNHKYDIDPESITPEDECPGGLVEY 544

  Fly   490 IITIVNNSQQMVELAQQMKQLY-------WPKSRTEHYEDFERLLATFQRIRAHAASYLLEEAFL 547
            :|.:.|:..:..:.|..:...|       :.|..|.|   .|..|..|..:...::..|:...|.
Yeast   545 LIAVSNDQMKAADYAVAISSKYGKLVSKVYEKQITNH---LEGTLDGFAEVAQCSSLGLITLMFD 606

  Fly   548 DMECHFNDLFTAKWLASNIAVDTICVTLDDYFQDYNHLRPN-NFEMVINEAQKLLAKRYIRALLS 611
            |:...:.::|:..|...:.| ..|..|||:|..|   ::|. |..:.:|....::.:..|:.|.:
Yeast   607 DLRKPYQEIFSKTWYMGSQA-QQIADTLDEYLLD---IKPQMNSVLFVNFIDNVIGETIIKFLTA 667

  Fly   612 KRLSKPRAECDAITRKIKTEAKRFKLFFEKIAPKISLSDSPLDLISTLSALLSSDIELLVLDLHT 676
              ||...:..:...:.::...:.|::|::.....:..::|...||:....::...::|....:.:
Yeast   668 --LSFEHSFKNKNNKFLEAMKRDFEIFYQLFVKVLDGNESKDTLITQNFTVMEFFMDLSCEPIDS 730

  Fly   677 LLGSYPSLNE-------DHLVRLFYIRNDVKAAEVREKVQDA 711
            :|..:....|       |.||.:...|.||.::|.::.||.|
Yeast   731 ILDIWQKYLEVYWDSRIDLLVGILKCRKDVSSSERKKIVQQA 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	124/639 (19%)
SEC6	NP_012196.1	SEC6	2..805	CDD:227500	157/822 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345984
Domainoid	1	1.000	60	1.000	Domainoid score	I2574
eggNOG	1	0.900	-	-		E1_COG5173
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	63	1.000	Inparanoid score	I1752
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55512
OrthoFinder	1	1.000	-	-		FOG0002440
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103744
Panther	1	1.100	-	-	LDO	PTHR21292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1313
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.830