DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and SEC6

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001185374.1	Gene:	SEC6 / 843512	AraportID:	AT1G71820	Length:	774	Species:	Arabidopsis thaliana

Alignment Length:	818	Identity:	156/818 - (19%)
Similarity:	300/818 - (36%)	Gaps:	191/818 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQQLEEQARQAALKDIQNMLQRPGQLEKVEQYR-HRIARKKASVEALLKTGMQGQLDGVRVGL 64
            |.::.|..:|::||::::..:|..|..|:.:...: ..|||::|: :|.|.|.:..|::..:.||
plant     1 MMVEDLGVEAKEAAVREVAKLLPLPELLQSISSIKADYIARQQAN-DAQLSTMVAEQVEQAQAGL 64

  Fly    65 KQLETCMQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQ 129
            :.|.:..:.:.|:|.....:::|.:....:.|..:.::..:...:.....:::::.:.::.....
plant    65 ESLSSSEKTIYELRDNFISIDKLCQECQTLIDNHDQIKLLSNARNNLNKTLKDVEGMMSISVEAA 129

  Fly   130 KTMALIEDDK-LLNAHQCLADLENSRDDLLYELHKQPKQHASDKI-TLKRHFEKVDTVSQELEKK 192
            .....:.||| ::|.::.|..|:..|...|        ..|.::: .|:.:||.||...:..||.
plant   130 AARDSLSDDKEIVNTYERLTALDGKRRFAL--------AAAGEEVGRLREYFEDVDRTWETFEKT 186

  Fly   193 ---------------------LRLILSRTLNTLRKKPTIIVTALR-------------------- 216
                                 |.:.|..|..:|...|..:|.|||
plant   187 LWGHVSNYYKLSKERYQILHILLVYLKLTDVSLFCSPQTLVRALRYDPPPETFFTFVYGIYSQII 251

  Fly   217 ---IIEREEKNDQFALQQQ-------KVTGFLPPGRP----KAWRRMIMDVLQQSVITRIEGSK- 266
               ::|.:|..||...::.       .:.....|.||    .........:.||.:..:.:|.|
plant   252 TFQVVEMQEILDQQLAEEAAEAEGEGAMASVANPRRPGKKSTTTSASSKGLAQQKLKVQGKGYKD 316

  Fly   267 ---------LEERADNKMWLV-RDLEIL---RQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYH 318
                     :|:|.:..:.|| .||:..   .::|.|:|..:.....|||||.|:||...|..|.
plant   317 KCYEQIRKAVEDRFNRLLTLVFEDLKAALEEARMIGEELGDIYDYVAPCFPPRYEIFQLMVNLYT 381

  Fly   319 EGLSSYLDNIV--RSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHRQIGTLLRPEHLKALE 381
            |.....|..:.  .:.|...|.:.:..||......:..:...|....|..:.|:      :..|.
plant   382 ERFIQMLRLLSDRANDLTNIEILKVTGWVVEYQENLIALGVDDSLAQVCSESGS------MDPLM 440

  Fly   382 DEYLQNMQRNFQEWMTKAAETEKQEWFTETVPDQDEE-YYHTSAPVIIFQMIDQHLQV------- 438
            :.|::.||...::|.....|.:|.:     .|.:.|| ..:|.|.|.:|:::.:.:.:
plant   441 NAYVERMQATTKKWYMNILEADKVQ-----PPKKTEEGKLYTPAAVDLFRILGEQVMIDFQAAEK 500

  Fly   439 ---------------TNTIHQELTFKALVMSIQQ--VEIFGQTYLKNVIELKEHHFRNRDQIKYF 486
                           ...|:..|....|.|.:..  :|...|.|.:.|      :|  .|..|.|
plant   501 KRVDEPASDIGLEPLCAMINNNLRCYDLAMELSNSTLEALPQNYAEQV------NF--EDTCKGF 557

  Fly   487 -------THYIITIVNNSQQMVELAQQMKQLYWPKSRTEHYEDFERLLATFQRIRAHAASYLLEE 544
                   .|..:.::.....:.||..::.|..|.:.:...|     |:|||.........|:.|.
plant   558 LEVAKEAVHQTVRVIFEDPGVQELLVKLYQKEWCEGQVTEY-----LVATFGDYFTDVKMYVEER 617

  Fly   545 AFLDMECHFNDLFTAKWLASNIAVDTICVTLDDYFQDYNHLRPNNFEMVINEAQKLLAKRYIRAL 609
            :|             :........:|:.|.:|       ||              |..|.||:.
plant   618 SF-------------RRFVEACLEETVVVYVD-------HL--------------LTQKNYIKE- 647

  Fly   610 LSKRLSKPRAECDAITRKIKTEAKRFKLFFEKI-APKISLSDSPLDLISTLSALLSSD-IELLVL 672
                        :.|.|....|......|.|.| |.|:   :|.:.::|.|..|.|:: ::...|
plant   648 ------------ETIERMRLDEEVLMDFFREYISASKV---ESRIRIMSDLRELASAESLDAFTL 697

  Fly   673 DLHTLLGSYPSLNEDHLVRLFYIRNDVKAAEVREKVQD 710
            ....:|...|....:.:.:|..:|..:...:.:|.||:
plant   698 VYSNILEHQPDCPAEVVEKLVSLREGIPRKDTKEVVQE 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	123/637 (19%)
SEC6	NP_001185374.1	Sec6	173..759	CDD:283659	123/637 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	75	1.000	Domainoid score	I3218
eggNOG	1	0.900	-	-		E1_COG5173
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I2074
OMA	1	1.010	-	-		QHG55512
OrthoDB	1	1.010	-	-		D391172at2759
OrthoFinder	1	1.000	-	-		FOG0002440
OrthoInspector	1	1.000	-	-		oto3868
orthoMCL	1	0.900	-	-		OOG6_103744
Panther	1	1.100	-	-	LDO	PTHR21292
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.880