Protein Alignment Sec6 and Exoc3l2

DIOPT Version :9

• Sequence 1: NP_611351.1
• Gene: Sec6 / 37142
• FlyBaseID: FBgn0266671
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001357729.1
• Gene: Exoc3l2 / 74463
• MGIID: 1921713
• Length: 789
• Species: Mus musculus
• Alignment Length: 667
• Identity: 140/667 - (20%)
• Similarity: 272/667 - (40%)
• Gaps: 78/667 - (11%)

  Fly    79 RRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTMALIEDDKLLNA 143
            ||....|||   ||    |.|...|...|..:.....|.|        ||.:.:.||:..:|..|
Mouse   140 RRASLAERL---VP----AGEAAPEPPPKVPEPPKIKEPL--------SVLEILGLIQRRELARA 189

  Fly   144 HQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELEKKLRLILSRTLNTLRKKP 208
            .:.:.:||          .:.|...|  :....|....|..:.:.|:::|..::..:|    ..|
Mouse   190 DEHILELE----------AEAPTAEA--EAGAGRRARDVALLYEALQRELWALVRESL----ASP 238

  Fly   209 ---TIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQQSVITRIEGSKLEER 270
               |..|:.|.::         .||::.......||..:..|....:     .:.|....:|||.
Mouse   239 GPGTGAVSQLGLV---------LLQEEAADARRGPGAARKLRTHWAE-----AVARAARERLEEA 289

  Fly   271 A--DNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSSYLDNIVRSGL 333
            |  ..:..|...||.||..:|||:..|:....|.:|........|::.|||.|:.:|....|..|
Mouse   290 AAPGARGALAGQLEALRARLLEDVAAVRGRLAPAYPAGLRAGAVYLRGYHEALAEWLGAAARRRL 354

  Fly   334 EGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHRQIGTLLRPEHLKALEDEYLQNMQRNFQEWMTK 398
            ...:..:::.|..|.||. |::...||....:.::|.||....|:.||||.:.:::...:..:.:
Mouse   355 PLADRYALLHWHNHVYPR-EILGLVDLVALENGELGPLLSAGTLRGLEDECVTDVKAQTRAALLR 418

  Fly   399 AAETEKQEWFTETVPDQDEEYYHTSAPVIIFQMIDQHLQVTNTIHQELTFKALVMSIQQVEIFGQ 463
            ..:.::::|       ...:|..::....:.:::::|.:....|.||...:.....:..:..|.|
Mouse   419 VLQEDEEQW-------GSMDYRPSNLAQDVCELLEEHTERAPHISQEFVERMAYCCLGGLAEFLQ 476

  Fly   464 TYLKNVIELKEH-HFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQLYWPKSRTEHYEDFERLL 527
            ::.:.|....|: ..|......|.:. .|::||....:..||:::.::..|:|....    |...
Mouse   477 SFQQRVERFHENPGIRELPSDTYISR-TISMVNCGPPLRSLAERLARVGPPESEPAR----EASA 536

  Fly   528 ATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTICVTLDDYFQDYNHLRPNNFEM 592
            ....|:.......|.|..|.:::.|||.|...|||:|:.|:|.|..||.........::...:::
Mouse   537 IALDRVTRLCHRVLAELLFQELQPHFNKLMRRKWLSSSEALDGIVGTLGAQALALRRMQDEPYQV 601

  Fly   593 VINEAQKLLAKRYIRALLSKRL----SKPRAECDAITRKIKTEAKRFKLFFEKIAPKISLSDSPL 653
            ::.|..:.....|:|.||..||    ::.|:.   :..:::.:|.:.:..|.::..:....|
Mouse   602 LVAELHRRALVEYVRPLLRGRLRCRSARTRSR---VAGRLREDAAQLQRLFRRLESQAYWLD--- 660

  Fly   654 DLISTLSALLS-SDIELLVLDLHTLLGSYPSLNEDHLVRLFYI---RNDVKAAEVREKVQDAMKS 714
            .::..|:.:|. .|...:.:::..|:..||.:...|:..|..|   ||.....|:....:|...|
Mouse   661 QVVPHLAEILQLEDTPSIQVEVGVLVRDYPDIRRKHVAALLDIRGLRNTAARQEILAVARDLELS 725

  Fly   715 KKAMVSIAKQDCIFKEI 731
            :...:..::....|.:|
Mouse   726 ESGALPPSRDRAFFADI 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	115/565 (20%)
Exoc3l2	NP_001357729.1	Sec6	215..742	CDD:388691	115/563 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940