DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and Exoc3l4

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001276416.1	Gene:	Exoc3l4 / 74190	MGIID:	1921363	Length:	721	Species:	Mus musculus

Alignment Length:	685	Identity:	133/685 - (19%)
Similarity:	260/685 - (37%)	Gaps:	89/685 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 REVRRRMDEVERLLRGVPE---VYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTMALIE 136
            |.:||.:|  |.|..|.|:   |.:....|.:..::.:...|..|:|:    ..|..:....||.
Mouse    85 RSLRRAID--EGLTAGHPQGPAVPEKPSKVTDGVSRQAATGTEAEDLE----PQAESKSVADLIT 143

  Fly   137 DDKLLNAHQCLADLENS--RDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELEKKLRLILSR 199
            :.:|:.|.:.|..||..  .|.......:.|..:|...:.|..|::       .:..::..|:..
Mouse   144 ERQLVKAFEQLRYLETQLVADKTSRTFTQDPTAYARRAMDLCLHYD-------GMAAEIGAIVRE 201

  Fly   200 TLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTG-FLPPGRPKAWRRMIMDVLQQSVITRIE 263
            .|::.......:....:::..||:    |.|..:..| ||  ..|:.||....|.::.|...|::
Mouse   202 ALSSEGVDRDALAELAQVVHLEEE----AHQTSQAEGDFL--STPRHWRMHWEDAVRLSAQERVQ 260

  Fly   264 --GSK-LEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCF-PPHYDIFGEYVKFYHEGLSSY 324
              |:| :...|:....|.:.|..|..::..||:.|:....|.: ...:.::..|::.:|..::..
Mouse   261 QAGAKVIPGAAEGSSDLAQLLAELGGVVRHDLQKVRLEMQPAYEATDFPVWETYLRAFHSAVAQR 325

  Fly   325 LDNIVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHRQIGTLLRPEHLKALEDEYLQNMQ 389
            |..:.|......:...::.|..:.|...:.:..|||.:.. ..:..||.|.....||.:|...::
Mouse   326 LQELARDARGCEQLYVLLDWAANVYGSPDFLGAPDLALPT-EPLPPLLEPALWARLESDYTSFLE 389

  Fly   390 RNFQEWMTKAAETEKQEWFTETVPDQDEE----YYHTSAPVIIFQMIDQHLQVTNTIHQELTFKA 450
            ...........:.|:..|    ..|:|.|    .||....:.:..::.:|::....|..||....
Mouse   390 TKITSCFDSILQLEQNRW----EADEDREVLQGLYHAPLSIDVHMLVAEHVKAAGAISAELEATT 450

  Fly   451 LVMSIQQVEIFGQTYLKNVIELKEHHFRNRDQIK--YFTHYIITIVN-NSQQMVELAQQMKQLYW 512
            |.:..:.:.:|...:.|..:..|        .:.  |...||...|. .:..:......:|:|..
Mouse   451 LQICARALCLFVPRFEKAFLASK--------AVSEWYLGAYINACVELRTSLLARFPGTIKELEK 507

  Fly   513 PKSRTEHYEDFERLLATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTICVTLD- 576
            |            |:|.....:.|    ||:....||:..|..|:|..||..    ||:...:|
Mouse   508 P------------LVAATNSFQKH----LLQIVQQDMQPLFKVLYTKSWLTQ----DTLRPLMDK 552

  Fly   577 --DYFQDYNHLRPNNFEMVINEAQKLLAKRYIRALLSKRLSKPRAECDAITR-----KIKTEAKR 634
              |:.....|:.|...:..:.|..:.:.:.|:..:|     :|........|     |:..:|:.
Mouse   553 VVDFAHHLEHVTPPLAQETLQEVHRFVVREYLGQVL-----RPHERFSGQDRLKGSNKMNLDAQA 612

  Fly   635 FKLFFEKIAPKIS-LSDSPLDLISTLSALLSSDIELLVLDLHTLLGSYPSLNEDHLVRLFYIR-- 696
            ....|:.:..:.. |..:.|.:...|......||.   ..|.||:.|||.:..||::.:..:|
Mouse   613 ISNTFQGLGSEAKWLDQAILSVAEILGETYKDDIR---RHLETLIRSYPDIRRDHILAILALRRL 674

  Fly   697 NDVKAAEVREKVQDAMKSKKAMVSIAKQDCIFKEI 731
            ...:...:.:..||.:::... ..:.....:|:||
Mouse   675 GRRRNQNLLQHTQDLLRAAHE-TRLPSHHVLFEEI 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	105/574 (18%)
Exoc3l4	NP_001276416.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..135		9/44 (20%)
		Sec6	182..708	CDD:368717	107/580 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5173
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391172at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850