DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and exoc3

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_997880.1	Gene:	exoc3 / 334015	ZFINID:	ZDB-GENE-030131-5947	Length:	748	Species:	Danio rerio

Alignment Length:	738	Identity:	289/738 - (39%)
Similarity:	451/738 - (61%)	Gaps:	20/738 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LEEQARQA---ALKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQL 67
            :||..|:|   |::.:..||||..||:||||||.|.|||||||||.||..:|.||||||.||.||
Zfish     1 MEETNREAVATAVQRVAGMLQRSDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLTQL 65

  Fly    68 ETCMQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTM 132
            ...:.||::::..:.:|.:..|......:.|:.|::...:|||.|:|:||||:||:|...|::|.
Zfish    66 HNALCDVKDIQNSLADVSKDWRQSINTIENLKDVKDAVVQHSQLASAVENLKNIFSVPEIVRETH 130

  Fly   133 ALIEDDKLLNAHQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELEKKLRLIL 197
            .|||..:||.||:.|.|||.|||||:||.::...::..|...::.:|.:|..:|:||.|:|.::|
Zfish   131 DLIEQGELLQAHRKLMDLECSRDDLMYEQYRMDSKNVHDMNLIRGYFGQVQGLSEELSKQLWMVL 195

  Fly   198 SRTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQQSVITRI 262
            .|.:.|:|:.||::|:.:||||||||.|:..|.::|.|||:||||||.|:..:.:||:.:|..||
Zfish   196 QRAMVTVRRDPTMLVSVVRIIEREEKIDRRMLDRKKQTGFIPPGRPKCWKNRMNEVLEGTVSGRI 260

  Fly   263 EGSKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSSYLDN 327
            |.::.|.|..:||||||.|||:|:.:|:||.|||:|.|.||||||:.|..:...||:.:|:.:..
Zfish   261 ESTQSETRESDKMWLVRLLEIMRKYVLDDLTVVKNLMVQCFPPHYNTFQVFFTLYHKAVSARVQE 325

  Fly   328 IVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVH-RQIGTLLRPEHLKALEDEYLQNMQRN 391
            :....||.||.|||:.|..:||..|::|.||||..:.. :|:..||..:.:..|..:||.....|
Zfish   326 LAAEELEANEIVSMLTWDLNTYKSVDMMGHPDLQPECEVKQLEPLLPEKVVNDLLGKYLTTFNSN 390

  Fly   392 FQEWMTKAAETEKQEWFTETVPDQDEE-YYHTSAPVIIFQMIDQHLQVTNTIHQELTFKALVMSI 455
            ...|:.||.||:|::|..||.|:.|:: ||.|:.|.|:|||.:|:|||...|::....|.|.:.:
Zfish   391 ITGWLRKALETDKKDWQKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQINEIFREKVLGVCL 455

  Fly   456 QQVEIFGQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQLYWPKSRTEHY 520
            :|:..|.:.|.:..|..||.|.::|...:.:..|:|.|:||.|...|....:|:.| .:|.....
Zfish   456 KQMNSFLKRYREEAIVYKEEHLKDRQLPQCYVQYMIAIINNCQTFKESINSLKRKY-SQSHEPTQ 519

  Fly   521 ED--FERLLATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTICVTLDDYFQDYN 583
            :|  .::||   ..:......:||:|.|||:|.|.|:|.|.|||....||||||||::|||.|:.
Zfish   520 DDATIDKLL---NDVAKEGCQFLLDEVFLDLELHLNELLTRKWLTGTHAVDTICVTVEDYFNDFA 581

  Fly   584 HL-RPNNFEMVINEAQKLLAKRYIRALLSKRLSKPRAE--CDAITRKIKTEAKRFKLFFEKIAPK 645
            .: :|.|.||. :.|.:.:...|::|::.||:|...|:  .:...|.:| ||::||..|.|::..
Zfish   582 KIKKPYNQEMT-SVAHRRVVFEYLKAIMYKRISFKNADERKEGADRMMK-EAEQFKFLFRKLSAG 644

  Fly   646 ISLSDSPLDLISTLSALLS-SDIELLVLDLHTLLGSYPSLNEDHLVRLFYIRNDVKAAEVREKVQ 709
            .. :|...|.|:.::.:.. :|..||.|::.||:..||.:.|:|::.|..||.|. :.|:|:.:.
Zfish   645 ED-TDRLCDSINAIAEVFKLTDPALLYLEVSTLVSKYPDIREEHILALLAIRGDA-SREMRQTII 707

  Fly   710 DAMKSKKAMVSIAKQDCIFKEIV 732
            :.:...|...|...|. :|::|:
Zfish   708 ETLNQNKPSTSSNFQP-VFRDII 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	209/559 (37%)
exoc3	NP_997880.1	Sec6	177..723	CDD:283659	207/553 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594426
Domainoid	1	1.000	372	1.000	Domainoid score	I848
eggNOG	1	0.900	-	-		E1_COG5173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38296
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1278
OMA	1	1.010	-	-		QHG55512
OrthoDB	1	1.010	-	-		D335038at33208
OrthoFinder	1	1.000	-	-		FOG0002440
OrthoInspector	1	1.000	-	-		oto39812
orthoMCL	1	0.900	-	-		OOG6_103744
Panther	1	1.100	-	-	LDO	PTHR21292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770