DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and Exoc3

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_796307.2	Gene:	Exoc3 / 211446	MGIID:	2443972	Length:	755	Species:	Mus musculus

Alignment Length:	748	Identity:	288/748 - (38%)
Similarity:	440/748 - (58%)	Gaps:	28/748 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQQLEEQARQAALKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLK 65
            :.:::.:.:|...|::.:..|||||.||:||||||.|.|||||||||.||..:|.||||||.||.
Mouse     9 LTMKETDLEAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLS 73

  Fly    66 QLETCMQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQK 130
            ||...:.||:::::.:.:|.:..|......::|:.|::...:|||.|.|:||||:||:|...|::
Mouse    74 QLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIFSVPEIVRE 138

  Fly   131 TMALIEDDKLLNAHQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELEKKLRL 195
            |..|||...||.||:.|.|||.|||.|:.|.::....:..|...:..:|.....:|.||.|:|.:
Mouse   139 TQDLIEQGALLQAHRKLMDLECSRDGLMCEQYRMDSGNKRDMTLIHGYFGSTQGLSDELAKQLWM 203

  Fly   196 ILSRTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQQSVIT 260
            :|.|:|.|:|:.||::|:.:||||||||.|:..|.::|.|||:||||||.|:..:..:|.::|.|
Mouse   204 VLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFAILDRTVTT 268

  Fly   261 RIEGSKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSSYL 325
            ||||::.:.|..:||||||.|||:|:.:|:||.|.|:|.|.||||||:||...:..||:.||:.:
Mouse   269 RIEGTQADTRESDKMWLVRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLSMYHQALSTRM 333

  Fly   326 DNIVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDL--NVDVHRQIGTLLRPEHLKALEDEYLQNM 388
            .::....||.||.||::.||.:||...|:|.:.:|  .||| ..:..||.|..:..|.|.|:..:
Mouse   334 QDLASEDLEANEIVSLLTWVLNTYTSAEMMGNVELAPEVDV-SALEPLLSPNIVSELLDTYMSTL 397

  Fly   389 QRNFQEWMTKAAETEKQEWFTETVPDQDEE-YYHTSAPVIIFQMIDQHLQVTNTIHQELTFKALV 452
            ..|...|:.||.||:|::|..||.|:.|:: ||.|:.|.|:|||.:|:|||...|.::|..|.||
Mouse   398 TSNIIAWLRKALETDKKDWSKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLV 462

  Fly   453 MSIQQVEIFGQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQLYWPKSRT 517
            :.:||:..|...|.......||.|.|||.....:..|:|.|:||.|...|....:|:.|   .:|
Mouse   463 LCLQQMNSFLSRYKDEAQLYKEEHLRNRQHPHCYVQYMIAIINNCQTFKESIISLKRKY---LKT 524

  Fly   518 EHYEDF----ERLLATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTICVTLDDY 578
            |..|..    ..:......|.....|.||||.|||:|.|.|:|.|.|||..:.|||.||||::||
Mouse   525 EAEEGLCLSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHLNELMTKKWLLGSNAVDIICVTVEDY 589

  Fly   579 FQDYNHLRPNNFEMVINEAQKLLAKRYIRALLSKRLS-------KPRAECDAITRKIKTEAKRFK 636
            |.|:..::....:.:..||.:.:...|:||::.||:|       |..||      |:..||::.:
Mouse   590 FNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSAEERKEGAE------KMVREAEQLR 648

  Fly   637 LFFEKIAPKISL-SDSPLDLISTLSALLS-SDIELLVLDLHTLLGSYPSLNEDHLVRLFYIRNDV 699
            ..|.|:|..... :|...|.|..::.::. :|..||.|::.||:..||.:.:||:..|..:|.|.
Mouse   649 FLFRKLASGFGEDADGHCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLALRGDA 713

  Fly   700 KAAEVREKVQDAMKSKKAMVSIAKQDCIFKEIV 732
             :.::::.:.:.:: :..|.:......||||||
Mouse   714 -SRDMKQTIMETLE-QGPMQASPNYVPIFKEIV 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	210/567 (37%)
Exoc3	NP_796307.2	Sec6	187..743	CDD:368717	210/567 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848889
Domainoid	1	1.000	371	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E1_COG5173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38296
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1323
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55512
OrthoDB	1	1.010	-	-		D335038at33208
OrthoFinder	1	1.000	-	-		FOG0002440
OrthoInspector	1	1.000	-	-		oto94412
orthoMCL	1	0.900	-	-		OOG6_103744
Panther	1	1.100	-	-	LDO	PTHR21292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1313
SonicParanoid	1	1.000	-	-		X4764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800