DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and sec-6

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_495006.2	Gene:	sec-6 / 173910	WormBaseID:	WBGene00017284	Length:	796	Species:	Caenorhabditis elegans

Alignment Length:	770	Identity:	224/770 - (29%)
Similarity:	405/770 - (52%)	Gaps:	51/770 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LEEQARQAALKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQLETC 70
            ::....:|||:.:..:||||.||||:.:.:.|..|||.:|||:|:||:||||:|:|..:..|:|.
Worm     1 MDVDVEEAALEQVAALLQRPDQLEKLPELKKRADRKKLAVEAMLRTGVQGQLEGIRTAIAHLQTA 65

  Fly    71 MQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTMALI 135
            ..|:..:.:.:.::...|...|::.:.|..:|:.|.:|.|||.||||||||||:..::|:....:
Worm    66 SDDITAISQGVHDIRERLGPFPQLKEKLRELRDANARHGQYAAAMENLKHIFNLQTTLQEIRDAL 130

  Fly   136 EDDK----LLNAHQCLADLENSRDDLLYELHKQPKQHA-SDKITLKRHFEKVDTVSQELEKKLRL 195
            :|:|    ||.||:.:.|||.:||:||.|:||....:. .:::.|...|:.||:|..||.|.:..
Worm   131 DDEKSGGNLLLAHKHIMDLERARDELLAEVHKMSGTNTEKEQMLLVNFFKGVDSVVAELSKNMWF 195

  Fly   196 ILSRTLNTLRKK-----PTIIVTALRIIEREEKNDQFALQ--QQKVTGFLPPGRPKAWRRMIMDV 253
            ||.|||..::..     |..:||.|||:||||:.|:|.::  .:..:.|:|||||:.|:...:..
Worm   196 ILGRTLEMVKGNEQGGGPQQVVTCLRIVEREERIDKFYMEARSKNSSAFVPPGRPRNWKEKALRS 260

  Fly   254 LQQSVITRIEGSKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYH 318
            |:::|..|::|::||:|:.||.||.|.||:.:.:|::||::.| :.:|||||.:.|:..||..||
Worm   261 LEKTVSNRVDGNQLEDRSLNKAWLARYLEVCKNVIMDDLQLAK-VAIPCFPPDWQIYDRYVHMYH 324

  Fly   319 EGLSSYLDNIVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHR--QIGTLLRPEHLKALE 381
            ..:...|..:....||.:|.|.:|:|:.. |...:::.||.|.::...  |...:|....|..|.
Worm   325 TSVCRRLREVASEHLEKSELVQLMSWIKF-YASEDMLGHPKLRINAQAILQDSPVLSRSTLNQLC 388

  Fly   382 DEYLQNMQRNFQEWMTKAAETEKQEWFTETVPDQDEE-YYHTSAPVIIFQMIDQHLQVTNTIHQE 445
            |::::..:.:.:.|:......|..:|:....|.:|.. |::|..|..:|.|:...:.:...:..|
Worm   389 DQFVEMSRDDLKLWLKNTVSHETHDWYKNLRPSEDNHGYFYTDLPNTVFGMLKDTVTLAKEVSVE 453

  Fly   446 LTFKALVMSIQQVEIFGQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQ- 509
            :....:.::||:.......|.......|..:|..|.:.:.||..||.|.||....:|..::.||
Worm   454 VIPSIINLTIQEFNELAGKYRDAFTAYKTDYFAERSKYQEFTSNIIAIANNLHTCIESTEKYKQQ 518

  Fly   510 --------------LYWPKS---RT-----EHYEDFERLLATFQRIRAHAASYLLEEAFLDMECH 552
                          :..|.:   ||     :..|:.:.|...:....:.|.:||.||...|:...
Worm   519 IRLSMEGEQNAAAAMTTPLASGRRTAVRQQQLIENMDALNTKWSNAASVAVNYLREEVITDIAPS 583

  Fly   553 FNDLFTAKWLASNIAVDTICVTLDDYFQDYNHLRPNNFEMVINEAQKLLAKRYIRALLSKRLSKP 617
            ..::|:.|||..:.|::|:|:|:.||:.|:.||||.....::.:.|..:...|::|:.:||:|..
Worm   584 LVEIFSKKWLTGSAALETVCMTISDYYHDHKHLRPVTRSTLLMDLQFRIVSEYLKAIETKRVSLN 648

  Fly   618 RAECDAIT-RKIKTEAKRFKLFFEKIAPKISLSDSPLDLISTLSA-----LLSSDIELLVLDLHT 676
            ..|..|:. :::|.:..|....:.:.|....::|. |.|::::.|     :...|..||.|:..:
Worm   649 SYEERALAGKRMKADVVRLDNLYAEFATSSDMADQ-LPLLTSIVAAAGDVISLKDKSLLSLEATS 712

  Fly   677 LLGSYPSLNEDHLVRLFYIRNDVKAAEVREKVQDAMKSKKAMVSIAKQDCIFKEI 731
            ....:|:...:.|..:...|:|:..:|.|....:.::.    |....:|.||.::
Worm   713 FARKFPNCPAELLSAVIATRDDISGSEARSLASEVLQH----VQFHPKDQIFDQL 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	157/590 (27%)
sec-6	NP_495006.2	Sec6	179..747	CDD:303062	153/570 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166127
Domainoid	1	1.000	251	1.000	Domainoid score	I1150
eggNOG	1	0.900	-	-		E1_COG5173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38296
Inparanoid	1	1.050	381	1.000	Inparanoid score	I1188
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55512
OrthoDB	1	1.010	-	-		D335038at33208
OrthoFinder	1	1.000	-	-		FOG0002440
OrthoInspector	1	1.000	-	-		oto19367
orthoMCL	1	0.900	-	-		OOG6_103744
Panther	1	1.100	-	-	LDO	PTHR21292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1313
SonicParanoid	1	1.000	-	-		X4764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840