DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and EXOC3

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_009208.2	Gene:	EXOC3 / 11336	HGNCID:	30378	Length:	745	Species:	Homo sapiens

Alignment Length:	744	Identity:	286/744 - (38%)
Similarity:	439/744 - (59%)	Gaps:	24/744 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQQLEEQARQAALKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQL 67
            :::.:.:|...|::.:..|||||.||:||||||.|.|||||||||.||..:|.||||||.||.||
Human     1 MKETDREAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQL 65

  Fly    68 ETCMQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTM 132
            ...:.||:::::.:.:|.:..|......::|:.|::...:|||.|.|:||||:||:|...|::|.
Human    66 HNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIFSVPEIVRETQ 130

  Fly   133 ALIEDDKLLNAHQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELEKKLRLIL 197
            .|||...||.||:.|.|||.|||.|:||.::....:..|...:..:|.....:|.||.|:|.::|
Human   131 DLIEQGALLQAHRKLMDLECSRDGLMYEQYRMDSGNTRDMTLIHGYFGSTQGLSDELAKQLWMVL 195

  Fly   198 SRTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQQSVITRI 262
            .|:|.|:|:.||::|:.:||||||||.|:..|.::|.|||:||||||.|:..:..:|:::|.|||
Human   196 QRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFTILERTVTTRI 260

  Fly   263 EGSKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSSYLDN 327
            ||::.:.|..:||||||.|||:|:.:|:||.|.|:|.|.||||||:||...:..||:.||:.:.:
Human   261 EGTQADTRESDKMWLVRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLNMYHQALSTRMQD 325

  Fly   328 IVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHRQIGT---LLRPEHLKALEDEYLQNMQ 389
            :....||.||.||::.||.:||...|:|.:.:|..:|  .:||   ||.|..:..|.|.|:..:.
Human   326 LASEDLEANEIVSLLTWVLNTYTSTEMMRNVELAPEV--DVGTLEPLLSPHVVSELLDTYMSTLT 388

  Fly   390 RNFQEWMTKAAETEKQEWFTETVPDQDEE-YYHTSAPVIIFQMIDQHLQVTNTIHQELTFKALVM 453
            .|...|:.||.||:|::|..||.|:.|:: ||.|:.|.|:|||.:|:|||...|.::|..|.||:
Human   389 SNIIAWLRKALETDKKDWVKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLVL 453

  Fly   454 SIQQVEIFGQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQLYWPKSRTE 518
            .:||:..|...|.......||.|.|||.....:..|:|.|:||.|...|....:|:.|......|
Human   454 CLQQMNSFLSRYKDEAQLYKEEHLRNRQHPHCYVQYMIAIINNCQTFKESIVSLKRKYLKNEVEE 518

  Fly   519 HYEDFERLL-ATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTICVTLDDYFQDY 582
            .....:..: .....|.....|.||||.|||:|.|.|:|.|.|||..:.|||.||||::|||.|:
Human   519 GVSPSQPSMDGILDAIAKEGCSGLLEEVFLDLEQHLNELMTKKWLLGSNAVDIICVTVEDYFNDF 583

  Fly   583 NHLRPNNFEMVINEAQKLLAKRYIRALLSKRLS-------KPRAECDAITRKIKTEAKRFKLFFE 640
            ..::....:.:..||.:.:...|:||::.||:|       |..||      |:..||::.:..|.
Human   584 AKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSPEERKEGAE------KMVREAEQLRFLFR 642

  Fly   641 KIAPKISLS-DSPLDLISTLSALLS-SDIELLVLDLHTLLGSYPSLNEDHLVRLFYIRNDVKAAE 703
            |:|...... |...|.|..::.::. :|..||.|::.||:..||.:.:||:..|..:|.|. :.:
Human   643 KLASGFGEDVDGYCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLAVRGDA-SRD 706

  Fly   704 VREKVQDAMKSKKAMVSIAKQDCIFKEIV 732
            :::.:.:.::...|..|.:... :||:||
Human   707 MKQTIMETLEQGPAQASPSYVP-LFKDIV 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	208/565 (37%)
EXOC3	NP_009208.2	Sec6	177..733	CDD:336281	208/565 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158488
Domainoid	1	1.000	376	1.000	Domainoid score	I872
eggNOG	1	0.900	-	-		E1_COG5173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38296
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1307
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55512
OrthoDB	1	1.010	-	-		D335038at33208
OrthoFinder	1	1.000	-	-		FOG0002440
OrthoInspector	1	1.000	-	-		oto90829
orthoMCL	1	0.900	-	-		OOG6_103744
Panther	1	1.100	-	-	LDO	PTHR21292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1313
SonicParanoid	1	1.000	-	-		X4764
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800