DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec6 and exoc3l1

DIOPT Version :9

Sequence 1:	NP_611351.1	Gene:	Sec6 / 37142	FlyBaseID:	FBgn0266671	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_002931727.3	Gene:	exoc3l1 / 100496045	XenbaseID:	XB-GENE-6258780	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	735	Identity:	193/735 - (26%)
Similarity:	369/735 - (50%)	Gaps:	32/735 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQQLEEQARQAALKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQL 67
            |::.|..||.||||....:..||.||.::..||.|..::..|::..||:.:|..|:||..|:|||
Frog    50 LEKAESLARGAALKWASGIFSRPDQLTRLGHYRRRETQRNNSIQTRLKSAVQSYLEGVEQGIKQL 114

  Fly    68 ETCMQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTM 132
            .:.:.:|:.|:|.:.|.:.:.|........|:.:|....:|.|.:..:::|..|:.|...:..|.
Frog   115 HSALTEVQNVQRELSEAQGIWRKTNGQLSRLQPIRNLVAEHVQLSVVIQSLPFIYTVPELISHTK 179

  Fly   133 ALIEDDKLLNAHQCLADLENSRDDLLYELHK------------QPKQHASDKITL-KRHFEKVDT 184
            .|||...||.||:.|.:||:.||.:||.|.:            :..||..|...| ::.|..|:.
Frog   180 NLIETQNLLEAHRNLRELESFRDIVLYRLQRVRPLEDPSCCTGEDVQHGEDPAELVQQFFAGVNN 244

  Fly   185 VSQELEKKLRLILSRTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRM 249
            :|::|.:.|..:...:::..|..|:::|:|:|||||||..|:...:......:.||||||.||..
Frog   245 LSEDLGRVLFSLAQSSVSLARSNPSLLVSAVRIIEREEYLDEEDTKGSPQQLWRPPGRPKHWRDS 309

  Fly   250 IMDVLQQSVITRIEGSKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYV 314
            ....|::.|..|:.||.|:|.......|....:.|:..:|::|:.|.|:..||.||.|::.....
Frog   310 FFQALERGVCNRLIGSGLQEEDITPTGLATHFKDLQSKVLDELQAVCSVLAPCVPPQYEVCRAVA 374

  Fly   315 KFYHEGLSSYLDNIVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVH-RQIGTLLRPEHLK 378
            ...|..:|.::.:|:...|.......::.|....||..:::.|.||:.::. .::|.||.||.|:
Frog   375 LMCHHAISRHVRDILSHDLAHPALYRVLHWSVIVYPSEDMIGHQDLSPEIDATELGALLSPEFLE 439

  Fly   379 ALEDEYLQNMQRNFQEWMTKAAETEKQEWFTETVPDQDEE-YYHTSAPVIIFQMIDQHLQVTNTI 442
            ..::.|.::::....:|:.||.|.|..|||.|..||:|:: .|.:|...:|.||:.:::|:.:.:
Frog   440 EQQNRYTRSVKVCLAQWIQKALEVEYSEWFREQEPDKDQDGLYLSSLQQLIMQMLAENMQLASVL 504

  Fly   443 HQELTFK---ALVMSIQQVEIF-GQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVEL 503
            ...|..:   |.|:.:....:: .:..:|..||    |.::|....|:..|::.|:|.   ...|
Frog   505 GDSLESRMRNAAVLEMDNCLVWLREALVKYGIE----HMKDRTNPTYYIPYLVAIING---CTAL 562

  Fly   504 AQQMKQLYWPKSRTEHY-EDFERLLATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIA 567
            :..:..|...:|..... ::...|..:..:.:..|...||:|...:::..|..:.:..||:.:..
Frog   563 SSSISYLQPGESANPVIRKNAPCLQNSLDKTQKKACHLLLDELQTELQPLFLQIPSRTWLSGSDI 627

  Fly   568 VDTICVTLDDYFQDYNHLRPNNFEMVINEAQKLLAKRYIRALL-SKRLSKPRAECDAITRKIKTE 631
            :...|..::.:.|..:..|....:.::.:.:::|...|::|.: ||.:.|...|...:..::.::
Frog   628 MRITCEKVELFNQHLSMARAPVCQFLLAQTERMLVIEYVKAFMHSKMVCKSSLERQQMAERMSSD 692

  Fly   632 AKRFKLFFEKIAPKISLSDSPLDL-ISTLSALLSSDIELLVLDLHTLLGSYPSLNEDHLVRLFYI 695
            |:..:....::..:.|....||.| |..:.||  .|..||.|::..|:.|:|.:::||::.|..:
Frog   693 AEELRAALSRMGLEESTLCVPLILSIQEIFAL--KDPSLLSLEVSGLMTSFPDISDDHVLALMEL 755

  Fly   696 RNDVKAAEVREKVQDAMKSK 715
            |.|| :.::|..|.:.|:.:
Frog   756 RGDV-SRDLRHTVLNMMQQQ 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec6	NP_611351.1	Sec6	179..731	CDD:283659	135/546 (25%)
exoc3l1	XP_002931727.3	Sec6	239..786	CDD:418703	135/546 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335038at33208
OrthoFinder	1	1.000	-	-		FOG0002440
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020