DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg7 and UBA4

DIOPT Version :9

Sequence 1:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_011979.1	Gene:	UBA4 / 856511	SGDID:	S000001153	Length:	440	Species:	Saccharomyces cerevisiae

Alignment Length:	364	Identity:	78/364 - (21%)
Similarity:	129/364 - (35%)	Gaps:	113/364 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 ISQTKCLLFGAGTLGCAVARNLLSWGFKHITLLDSGKVGFSNPVRQNLYTHADAVAGNRMKATTA 401
            :..||.|:.|||.|||.....|...|...|.::|:..|..||..||.|:   |:.....:|..:|
Yeast    65 LKNTKVLVVGAGGLGCPALPYLAGAGVGQIGIVDNDVVETSNLHRQVLH---DSSRVGMLKCESA 126

  Fly   402 AQRLKEINPSAETAGYVLEIPMPGHTIGESLLAQTKEHLKVIEKLVQDHDVIFLLTDSRESRWLP 466
            .|.:.::||......|.:.:                 :......:.:.::.|...|||..:|:|
Yeast   127 RQYITKLNPHINVVTYPVRL-----------------NSSNAFDIFKGYNYILDCTDSPLTRYL- 173

  Fly   467 TLLGAAKEKIVINAALGFDSYLVMRHGTTRKEAGDDGQEIEGLKCINGDQLG-CYFCNDVT-APG 529
                      |.:.|:.....:|...|     .|.:||    |..:|.:.:| ||.|...| .|.
Yeast   174 ----------VSDVAVNLGITVVSASG-----LGTEGQ----LTILNFNNIGPCYRCFYPTPPPP 219

  Fly   530 NSLKDRTLDQQCTVTRPGVSNIAASYAVELLVALLQ-HPRKELAPAYYAQSG-----------RG 582
            |::   |..|:..|..|.:..:....|||.|..:|. :..:..:|.....||           ||
Yeast   220 NAV---TSCQEGGVIGPCIGLVGTMMAVETLKLILGIYTNENFSPFLMLYSGFPQQSLRTFKMRG 281

  Fly   583 RSEE----------TEEKVPEGLLGILPHSIRGMLCNYENILPATQKFAQCIACSAAVLNEYKKE 637
            |.|:          |:|.:.:|.:            |||            :.|.|...|..:.
Yeast   282 RQEKCLCCGKNRTITKEAIEKGEI------------NYE------------LFCGARNYNVCEP- 321

  Fly   638 GHAFLFKTFETAKFLEDLTGISEFKRLNSEIIDFDDEEF 676
                           ::...:..|:|:      :.|:||
Yeast   322 ---------------DERISVDAFQRI------YKDDEF 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029
		E1_like_apg7	11..682	CDD:273590	78/364 (21%)
		Apg7	341..658	CDD:238763	72/340 (21%)
UBA4	NP_011979.1	ThiF_MoeB_HesA_family	46..279	CDD:238386	60/256 (23%)
UBA4	NP_011979.1	RHOD_ThiF	316..440	CDD:238784	6/46 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810