DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg7 and Uba5

DIOPT Version :9

Sequence 1:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_079968.2	Gene:	Uba5 / 66663	MGIID:	1913913	Length:	403	Species:	Mus musculus

Alignment Length:	257	Identity:	50/257 - (19%)
Similarity:	89/257 - (34%)	Gaps:	57/257 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 RLVPDLNLEIISQTKCL------LFGAGTLGCAVARNLLSWGFKHITLLDSGKVGFSNPVRQNLY 385
            ||:....:.|:|..|.:      :.|.|.:|...|..|...|...:.|.|..||..:|..|....
Mouse    53 RLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQ 117

  Fly   386 THADAVAGNRMKATTAAQRLKEINPSA--ETAGYVLEIPMPGHTIGESLLAQTKEHLKVIEKLV- 447
            .:...::    |...|...|:.|||..  |...|.:               .|.||.:.....:
Mouse   118 PYQAGLS----KVHAAEHTLRNINPDVLFEVHNYNI---------------TTVEHFEHFMNRIS 163

  Fly   448 -------QDHDVIFLLTDSRESRWLPTLLGAAKEKIVINAALGFDSYLVMRHGTTRKEAGDDGQE 505
                   |..|::....|:.|:|            :.||.|..       ..|.|..|:|.....
Mouse   164 NGGLEEGQPVDLVLSCVDNFEAR------------MAINTACN-------ELGQTWMESGVSENA 209

  Fly   506 IEG-LKCINGDQLGCYFCNDVTAPGNSLKDRTLDQQ--CTVTRPGVSNIAASYAVELLVALL 564
            :.| ::.:...:..|:.|.......:::.::||.::  |..:.|....:.|...|:.::..|
Mouse   210 VSGHIQLMIPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFL 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029
		E1_like_apg7	11..682	CDD:273590	50/257 (19%)
		Apg7	341..658	CDD:238763	46/243 (19%)
Uba5	NP_079968.2	ThiF_MoeB_HesA_family	50..293	CDD:238386	50/257 (19%)
		ThiF	51..307	CDD:279270	50/257 (19%)
		UFM1-interacting sequence (UIS). /evidence=ECO:0000250\|UniProtKB:Q9GZZ9	333..345
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900