DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg7 and Sae1

DIOPT Version :9

Sequence 1:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001272820.1	Gene:	Sae1 / 56459	MGIID:	1929264	Length:	350	Species:	Mus musculus

Alignment Length:	309	Identity:	64/309 - (20%)
Similarity:	106/309 - (34%)	Gaps:	74/309 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 ENSVNLNLKLMKWRLVPDLNLEIISQTKCLLFGAGTLGCAVARNLLSWGFKHITLLDSGKVGFSN 378
            |.:...:.::..|.|.....|.   .::.|:.|...||..:|:||:..|.|.:|:||..:|...:
Mouse    18 EEAAQYDRQIRLWGLEAQKRLR---ASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPED 79

  Fly   379 PVRQNLYTHADAVAGNRMKATTAAQRLKEINPSAETAGYVLEIPMPGHTIGESLLAQTKEHLKVI 443
            |..|.| ....:|..||.:|  :.:|.:.:||..:                  :...|::..|..
Mouse    80 PGAQFL-IQTGSVGRNRAEA--SLERAQNLNPMVD------------------VKVDTEDVEKKP 123

  Fly   444 EKLVQDHDVIFLLTDSRESRWLPTLLGAAKEKIVI--------NAALGFDSYLVMRHGTTRKEAG 500
            |......|.:.|...||:              ::|        |:...|...:...||.|....|
Mouse   124 ESFFTKFDAVCLTCCSRD--------------VIIKVDQICHRNSIKFFTGDVFGYHGYTFANLG 174

  Fly   501 DDGQEIEGLKCINGDQLGCYFCNDVTAPGNSLKDRTLD-QQCTVTR------PGVSNIAASYAVE 558
            :.....|..|.....|        ....|...|...|| .:.|:.:      |....:...::.|
Mouse   175 EHEFVEEKTKVAKVSQ--------GVEDGPEAKRAKLDSSETTMVKKKVLFCPVKEALEVDWSGE 231

  Fly   559 LLVALLQHPRKELAPAYY---------AQSGRGRSEETEEKVPEGLLGI 598
            ...|.|    |..||.|:         ...||..:.|:.::..|.||.|
Mouse   232 KAKAAL----KRTAPDYFLLQVLLKFRTDKGRDPTSESYKEDAELLLQI 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029
		E1_like_apg7	11..682	CDD:273590	64/309 (21%)
		Apg7	341..658	CDD:238763	60/282 (21%)
Sae1	NP_001272820.1	Aos1_SUMO	20..345	CDD:238769	63/307 (21%)
Sae1	NP_001272820.1	ThiF	23..338	CDD:279270	63/304 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900