DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg7 and Mocs3

DIOPT Version :9

Sequence 1:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001101274.1	Gene:	Mocs3 / 311655	RGDID:	1307044	Length:	458	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	102/435 - (23%)
Similarity:	163/435 - (37%)	Gaps:	120/435 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 AKLAENSVNLNLKLMKWRLVPDLNLE---IISQTKCLLFGAGTLGCAVARNLLSWGFKHITLLDS 371
            |.|:.:.:   |:..:..|:|:|.:.   .::....|:.|.|.|||.:|:.|.:.|...:.|:|.
  Rat    51 AALSRDEI---LRYSRQLLLPELGVRGQLRLAAASVLVVGCGGLGCPLAQYLAAAGVGRLGLVDH 112

  Fly   372 GKVGFSNPVRQNLYTHADAVAGNRMKATTAAQRLKEINPSAETAGYVLEIPMPGHTIGESLLAQT 436
            ..|..||..||.|  |.:|.||: .||.:||..|:.:|.:.|...|       ...:.|:....
  Rat   113 DVVETSNLARQVL--HGEAQAGH-AKAWSAAAALRRLNSAVEYVPY-------ARALSEAWALD- 166

  Fly   437 KEHLKVIEKLVQDHDVIFLLTDSRESRWLP----TLLGAAKEKIVINAALGFDSYLVMRH----- 492
                     ||:.:||:...:|:..:|:|.    .|.|   ..:|..:||.|:..:.:.|
  Rat   167 ---------LVRGYDVVADCSDNVPTRYLVNDACVLAG---RPLVSASALRFEGQMTVYHYDDGP 219

  Fly   493 -----------GTTRKEAGDDG------------QEIEGLKCING------------DQLGCYFC 522
                       ..|.....|.|            |.:|.||...|            |.||.:|.
  Rat   220 CYRCVFPRPPPAETVTNCADGGVLGVVPGVLGCVQALEVLKIAAGLGTTYSGSMLLFDGLGGHFR 284

  Fly   523 NDVTAPGNSLKDRTLD-----QQCTVTRPGVSNIAA---SYAVELLVAL-LQHPRKELAPAYYAQ 578
            .      ..|:.|..|     ||.|||  .:.|..|   |.|.:...:| |..|.:.::...|.:
  Rat   285 R------IRLRRRRPDCVVCGQQPTVT--CLKNYEAFCGSSATDKCRSLKLLSPEERISVTDYKR 341

  Fly   579 ---SGRGRSEETEEKVPEGLLGILPHSIRGMLCNYENIL--PAT---QKFAQCIACSAAVLNEYK 635
               ||          ||..||.:.| .:...:|..::.|  |.:   ::.|..:....|.|.|.|
  Rat   342 LLDSG----------VPHVLLDVRP-QVEVDICRLQHSLHIPLSLLERRDADSLKLLGAALQEEK 395

  Fly   636 K---EGHAFLFKTF--------ETAKFLEDLTGISEFKRLNSEII 669
            :   ||.|......        :..:.|:.||.:.|...|..:.|
  Rat   396 RNSQEGAALAVYVICKLGNDSQKAVRVLQSLTAVPELDSLKVQDI 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029
		E1_like_apg7	11..682	CDD:273590	102/435 (23%)
		Apg7	341..658	CDD:238763	93/388 (24%)
Mocs3	NP_001101274.1	PRK07411	53..458	CDD:180967	101/433 (23%)
		ThiF_MoeB_HesA_family	60..283	CDD:238386	58/245 (24%)
		RHOD_ThiF	325..458	CDD:238784	28/127 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810