DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg7 and MOCS3

DIOPT Version :9

Sequence 1:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_055299.1	Gene:	MOCS3 / 27304	HGNCID:	15765	Length:	460	Species:	Homo sapiens

Alignment Length:	300	Identity:	72/300 - (24%)
Similarity:	118/300 - (39%)	Gaps:	79/300 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 RMVCMRDSMDPAKLAENSVNLNLKLMKWRLVPDLNL--EIISQTKC-LLFGAGTLGCAVARNLLS 360
            |:|.:......|.|:.:.:   |:..:..::|:|.:  ::...|.| |:.|.|.|||.:|:.|.:
Human    42 RLVPVSPLPPKAALSRDEI---LRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAA 103

  Fly   361 WGFKHITLLDSGKVGFSNPVRQNLYTHADAVAGNRMKATTAAQRLKEINPSAETAGYVLEIPMPG 425
            .|...:.|:|...|..||..||.|  |.:|:|| :.||.:||..|:.:|.:.|...|.
Human   104 AGVGRLGLVDYDVVEMSNLARQVL--HGEALAG-QAKAFSAAASLRRLNSAVECVPYT------- 158

  Fly   426 HTIGESLLAQTKEHLKVIEKLVQDHDVIFLLTDSRESRWLP----TLLGAAKEKIVINAALGFDS 486
                ::|...|      ...||:.:||:...:|:..:|:|.    .|.|   ..:|..:||.|:.
Human   159 ----QALTPAT------ALDLVRRYDVVADCSDNVPTRYLVNDACVLAG---RPLVSASALRFEG 210

  Fly   487 YLVMRH----------------GTTRKEAGDDG------------QEIEGLKCING--------- 514
            .:.:.|                ..|.....|.|            |.:|.||...|
Human   211 QITVYHYDGGPCYRCIFPQPPPAETVTNCADGGVLGVVTGVLGCLQALEVLKIAAGLGPSYSGSL 275

  Fly   515 ---DQLGCYFCNDVTAPGNSLKDRTLDQQCTVTRPGVSNI 551
               |.|..:|      ....|:.|.||......||.|:::
Human   276 LLFDALRGHF------RSIRLRSRRLDCAACGERPTVTDL 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029	2/3 (67%)
		E1_like_apg7	11..682	CDD:273590	72/299 (24%)
		Apg7	341..658	CDD:238763	64/255 (25%)
MOCS3	NP_055299.1	ThiF_MoeB_HesA_family	62..285	CDD:238386	59/245 (24%)
MOCS3	NP_055299.1	RHOD_ThiF	327..460	CDD:238784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810