DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg7 and Uba6

DIOPT Version :9

Sequence 1:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_766300.1	Gene:	Uba6 / 231380	MGIID:	1913894	Length:	1053	Species:	Mus musculus

Alignment Length:	305	Identity:	53/305 - (17%)
Similarity:	96/305 - (31%)	Gaps:	114/305 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 DLNLEIISQTKCLLFGAGTLGCAVARNLLSWGFKHITLLDSGK-----VGFSNPVRQNLYTHADA 390
            |..::.::::...|.|.|.||..:|:||:..|.|.:|:.|:.|     :|      .|.:...|.
Mouse    53 DTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQAWDLG------TNFFLCEDD 111

  Fly   391 VAGNRMKATTAAQRLKEINPSAETAG--------------------YVLEIPM------------ 423
            |...|.:|.....|:.|:||..:.:.                    .:.||.:
Mouse   112 VVNERNRAEAVLHRIAELNPYVQVSSSSAPLDETTDLSFLEKYQCVVLTEIKLTLQKKINNFCHS 176

  Fly   424 ----------PGHTIGESLLAQTKEHLKVIEKLVQDHDVIFLLTDSRESRWLPTLLGAAKEKIVI 478
                      ..|.|...|.....:..:|.:...::...||:...::.:..:.|.|.:...|:..
Mouse   177 HCPPIKFISADVHGIWSRLFCDFGDEFEVSDTTGEEPKEIFISNITQANPGIVTCLESHPHKLET 241

  Fly   479 NAALGFDSYLVMRHGTTRKEAGDDGQEIEGLKCINGDQLGCYFCNDVTAPGNSLKDRTLDQQCTV 543
            ...|.|                   :||.|:..:||..                      ||.||
Mouse   242 GQFLTF-------------------REIHGMTGLNGSV----------------------QQITV 265

  Fly   544 TRP-----------------GVS---NIAASYAVELLVALLQHPR 568
            ..|                 |::   ....::..|.|.:.::|||
Mouse   266 ISPFSFSIGDTTKLDPYLHGGIAVQVKTPKTFCFEPLESQIKHPR 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029
		E1_like_apg7	11..682	CDD:273590	53/305 (17%)
		Apg7	341..658	CDD:238763	52/295 (18%)
Uba6	NP_766300.1	Ube1	38..1046	CDD:273603	53/305 (17%)
		Ube1_repeat1	43..432	CDD:238768	53/305 (17%)
		E1_4HB	299..362	CDD:292809	5/12 (42%)
		Ube1_repeat2	462..1005	CDD:238767
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900