DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg7 and SAE1

DIOPT Version :9

Sequence 1:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_005491.1	Gene:	SAE1 / 10055	HGNCID:	30660	Length:	346	Species:	Homo sapiens

Alignment Length:	298	Identity:	61/298 - (20%)
Similarity:	105/298 - (35%)	Gaps:	52/298 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 ENSVNLNLKLMKWRLVPDLNLEIISQTKCLLFGAGTLGCAVARNLLSWGFKHITLLDSGKVGFSN 378
            |.:...:.::..|.|.....|.   .::.||.|...||..:|:||:..|.|.:|:||..:|...:
Human    14 EEAAQYDRQIRLWGLEAQKRLR---ASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPED 75

  Fly   379 PVRQNLYTHADAVAGNRMKATTAAQRLKEINPSAETAGYVLEIPMPGHTIGESLLAQTKEHLKVI 443
            |..|.| ....:|..||.:|  :.:|.:.:||..:                  :...|::..|..
Human    76 PGAQFL-IRTGSVGRNRAEA--SLERAQNLNPMVD------------------VKVDTEDIEKKP 119

  Fly   444 EKLVQDHDVIFLLTDSRESRWLPTLLGAAKEKIVI--------NAALGFDSYLVMRHGTTRKEAG 500
            |......|.:.|...||:              :::        |:...|...:...||.|....|
Human   120 ESFFTQFDAVCLTCCSRD--------------VIVKVDQICHKNSIKFFTGDVFGYHGYTFANLG 170

  Fly   501 DDGQEIEGLKCINGDQLGCYFCNDVTAPGNSLKDRTLDQQCTVTRPGVSNIAASYAVELLVALLQ 565
            :.....|..|.....| |.....|.........:.|:.::..|..|....:...::.|...|.|:
Human   171 EHEFVEEKTKVAKVSQ-GVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALK 234

  Fly   566 HPRK-----ELAPAYYAQSGRGRSEETEEKVPEGLLGI 598
            ....     ::...:....||..|.:|.|:..|.||.|
Human   235 RTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQI 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029
		E1_like_apg7	11..682	CDD:273590	61/298 (20%)
		Apg7	341..658	CDD:238763	57/271 (21%)
SAE1	NP_005491.1	Aos1_SUMO	16..341	CDD:238769	60/296 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900