DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg7 and UBA2

DIOPT Version :9

Sequence 1:	NP_611350.1	Gene:	Atg7 / 37141	FlyBaseID:	FBgn0034366	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_005258461.2	Gene:	UBA2 / 10054	HGNCID:	30661	Length:	752	Species:	Homo sapiens

Alignment Length:	270	Identity:	56/270 - (20%)
Similarity:	104/270 - (38%)	Gaps:	70/270 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KALDKLQL-LAD--EGKELLADMCSGGALRDPSLLTRFFVLSFADLKCH-------SYYYWFAFP 145
            |:::.|:: ||:  :|.||:.|.      .|||.:.  ||.|.|:|:.|       |.:...:..
Human   436 KSIETLRVHLAEKGDGAELIWDK------DDPSAMD--FVTSAANLRMHIFSMNMKSRFDIKSMA 492

  Fly   146 CPLTPTLK-----------------LQGAVQKLRDL-----PNSSSYIMALKALPTESQNFFILY 188
            ..:.|.:.                 |.|.:.:.|.:     ||....::...||...:.|.::..
Human   493 GNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCA 557

  Fly   189 A----NVEKNIFEARSLSSLDDKNVEFCYFGFADPSEYEHPAWIMRNYAAFLLQ----QCPSFVG 245
            :    .|..|:.:...| :|.||.|:..:...|...:.|.      .....|:.    :..:...
Human   558 SKPEVTVRLNVHKVTVL-TLQDKIVKEKFAMVAPDVQIED------GKGTILISSEEGETEANNH 615

  Fly   246 KPLKFLGLRHNQQMNIDD-----SLVWKVIQTEACDLSQSENIKFVGWELNKNGKMGPRMVCMRD 305
            |.|...|:|:..::..||     :|:..::.:|  ||.:....:.||   :...|:||     :.
Human   616 KKLSEFGIRNGSRLQADDFLQDYTLLINILHSE--DLGKDVEFEVVG---DAPEKVGP-----KQ 670

  Fly   306 SMDPAKLAEN 315
            :.|.||...|
Human   671 AEDAAKSITN 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg7	NP_611350.1	ATG7_N	9..303	CDD:293029	52/256 (20%)
		E1_like_apg7	11..682	CDD:273590	56/270 (21%)
		Apg7	341..658	CDD:238763
UBA2	XP_005258461.2	Uba2_SUMO	159..556	CDD:238766	27/127 (21%)
		UBA_e1_thiolCys	291..474	CDD:287545	15/45 (33%)
		UAE_UbL	564..650	CDD:291402	18/94 (19%)
		UBA2_C	661..747	CDD:292812	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900