DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5335 and LGALS9C

DIOPT Version :9

Sequence 1:	NP_611349.2	Gene:	CG5335 / 37140	FlyBaseID:	FBgn0034365	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001035167.2	Gene:	LGALS9C / 654346	HGNCID:	33874	Length:	356	Species:	Homo sapiens

Alignment Length:	374	Identity:	85/374 - (22%)
Similarity:	132/374 - (35%)	Gaps:	110/374 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FAGNLSHPLEFGHVLEVVAKTIDGA------ARFHINLCTAKSTVDPNADIGLRFSCYFRN-DVI 62
            |:|.:...|:.|..:     |::||      .||.::..|..|    ..||...|:..|.: ..:
Human    17 FSGTIQGGLQDGFQI-----TVNGAVLSCSGTRFAVDFQTGFS----GNDIAFHFNPRFEDGGYV 72

  Fly    63 VRNSRINGAWGEEESHVMDPNTLPNPIVSGEFFLVYILCCEDSFAISINSREFCRFRYRMPLGTI 127
            |.|:|..|.||.||      ..:..|...|..|.:..|.....|.:.:|...|.::.:|:|...:
Human    73 VCNTRQKGTWGPEE------RKMHMPFQKGMPFDLCFLVQSSDFKVMVNGSLFVQYFHRVPFHRV 131

  Fly   128 RALEIRDQIQVIKQVDHRTVFPNPWPAVHASDYFKAFSNDQPILF-----------------SPG 175
            ..:.:...:|:     ....|.|| .||.....|......||:.|                 :|.
Human   132 DTISVNGSVQL-----SYISFQNP-RAVPVQPAFSTVPFSQPVCFPPRPRGRRQKPPSVRPANPA 190

  Fly   176 HVIVLTARCFENKKGQ-----------------FIIKFMDS-------------------DTKRE 204
            .:........::..||                 :.:.|:.:                   ..:|.
Human   191 PITQTVIHTVQSASGQMFSQTPAIPPMMYPHPAYPMPFITTIPGGLYPSKSIILSGTVLPSAQRF 255

  Fly   205 EL----------HFSVRFDEKAVVRNSMNKNFEFGSEERH--GGFPFVFNQQFKLALAFTEREVL 257
            .:          |.:.||||.|||||:...| .:|||||.  ...|||..|.|.:.:......:.
Human   256 HINLCSGSHIAFHMNPRFDENAVVRNTQINN-SWGSEERSLPRKMPFVRGQSFSVWILCEAHCLK 319

  Fly   258 TAVDGYNFFSYTWRTPNAMMNLVGFKVTSINGLVV----QITGVDHLQT 302
            .||||.:.|.|..|..|         :.:||.|.|    |:|   |:||
Human   320 VAVDGQHVFEYYHRLRN---------LPTINKLEVGGDIQLT---HVQT 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5335	NP_611349.2	Gal-bind_lectin	5..140	CDD:278752	33/141 (23%)
CG5335	NP_611349.2	GLECT	172..297	CDD:238025	41/193 (21%)
LGALS9C	NP_001035167.2	GLECT	16..146	CDD:238025	33/148 (22%)
		Beta-galactoside binding 1. /evidence=ECO:0000250	82..88		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..190		1/19 (5%)
		Gal-bind_lectin	233..355	CDD:214904	37/134 (28%)
		Beta-galactoside binding 2. /evidence=ECO:0000250	288..294		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357844at33208
OrthoFinder	1	1.000	-	-		FOG0000178
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4988
SonicParanoid	1	1.000	-	-		X133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950