DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5335 and LGALS9B

DIOPT Version :9

Sequence 1:	NP_611349.2	Gene:	CG5335 / 37140	FlyBaseID:	FBgn0034365	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001354221.1	Gene:	LGALS9B / 284194	HGNCID:	24842	Length:	356	Species:	Homo sapiens

Alignment Length:	371	Identity:	88/371 - (23%)
Similarity:	135/371 - (36%)	Gaps:	104/371 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FAGNLSHPLEFGHVLEVVAKTIDGA------ARFHINLCTAKSTVDPNADIGLRFSCYFRN-DVI 62
            |:|.:...|:.|..:     |::||      .||.::..|..|    ..||...|:..|.: ..:
Human    17 FSGTIQGGLQDGFQI-----TVNGAVLSSSGTRFAVDFQTGFS----GNDIAFHFNPRFEDGGYV 72

  Fly    63 VRNSRINGAWGEEESHVMDPNTLPNPIVSGEFFLVYILCCEDSFAISINSREFCRFRYRMPLGTI 127
            |.|:|..|.||.||      ..:..|...|..|.:..|.....|.:.:|...|.::.:|:|...:
Human    73 VCNTRQKGRWGPEE------RKMHMPFQKGMPFDLCFLVQSSDFKVMVNGSLFVQYFHRVPFHRV 131

  Fly   128 RALEIRDQIQV--IKQVDHRTV----------------FP----------------NPWP----A 154
            ..:.:...:|:  |...:.|||                ||                ||.|    .
Human   132 DTISVNGSVQLSYISFQNPRTVPVQPAFSTVPFSQPVCFPPRPRGRRQKPPSVRPANPAPITQTV 196

  Fly   155 VH-----ASDYFKAFSNDQPILFS-----------------PGHVIVLTARCFENKKGQFIIKFM 197
            :|     :...|.......|:::.                 |...|:|:.....:.: :|.|...
Human   197 IHTVQSASGQMFSQTPAIPPMMYPHPAYPMPFITTIPGGLYPSKSIILSGTVLPSAQ-RFHINLC 260

  Fly   198 DSDTKREELHFSVRFDEKAVVRNSMNKNFEFGSEERH--GGFPFVFNQQFKLALAFTEREVLTAV 260
            ..  .....|.:.||||.|||||:...| .:|||||.  ...|||..|.|.:.:......:..||
Human   261 SG--SHIAFHMNPRFDENAVVRNTQINN-SWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAV 322

  Fly   261 DGYNFFSYTWRTPNAMMNLVGFKVTSINGLVV----QITGVDHLQT 302
            ||.:.|.|..|..|         :.:||.|.|    |:|   |:||
Human   323 DGQHVFEYYHRLRN---------LPTINKLEVGGDIQLT---HVQT 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5335	NP_611349.2	Gal-bind_lectin	5..140	CDD:278752	33/143 (23%)
CG5335	NP_611349.2	GLECT	172..297	CDD:238025	40/147 (27%)
LGALS9B	NP_001354221.1	GLECT	16..146	CDD:238025	33/143 (23%)
		Beta-galactoside binding 1. /evidence=ECO:0000250	82..88		4/11 (36%)
		DNA_pol3_gamma3	<150..>227	CDD:331207	11/76 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..190		3/19 (16%)
		Gal-bind_lectin	233..355	CDD:214904	41/137 (30%)
		Beta-galactoside binding 2. /evidence=ECO:0000250	288..294		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357844at33208
OrthoFinder	1	1.000	-	-		FOG0000178
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920