DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment JAG2 and Ser

DIOPT Version :10

Sequence 1:NP_002217.3 Gene:JAG2 / 3714 HGNCID:6189 Length:1238 Species:Homo sapiens
Sequence 2:NP_524527.3 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster


Alignment Length:1406 Identity:487/1406 - (34%)
Similarity:641/1406 - (45%) Gaps:334/1406 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    13 LLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACC--DGDGRTTRAGGCGHDECDTYVRVCL 75
            :.|:|.|.|......|.|||::..:.|.|..||:|.||  ..:.|.|:..||  ..|.|..|:||
  Fly    69 IALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGC--SPCTTAFRLCL 131

Human    76 KEYQ-----AKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGL--VVIP 133
            ||||     |.:: || ||:|:..|.:|||:||.|                   .|||:  :|:|
  Fly   132 KEYQTTEQGASIS-TG-CSFGNATTKILGGSSFVL-------------------SDPGVGAIVLP 175

Human   134 FQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRC 198
            |.|.|.:|||||::|.|..|.:.|:.|.|||..|::|:|.|...||:|...|..|.:..::||:|
  Fly   176 FTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQC 240

Human   199 DENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECR 263
            ...||:.||..|||||:|.||||.|...|.|.|::||.|..|:||:||.||:.:||.|..||||.
  Fly   241 AVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECE 305

Human   264 CSYGWQGRFCDECVPYPGCVHGSC-VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAE 327
            |..||:|..|:||:.||||.|||| ...|:|.|:|||||:|||:|||:||:|.||.:||||.|..
  Fly   306 CRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTA 370

Human   328 PDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC------------------------------ 362
            ||:|||||.:|.||..||..||.|.:.||.|||:|                              
  Fly   371 PDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSS 435

Human   363 ------HEVPSG--------------------------FECHCPSGWSGPTCALDIDECASNPCA 395
                  |..|.|                          |.|.|.:||:||||.::|||||..||.
  Fly   436 SMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCE 500

Human   396 AGGTCVDQVDGFECICPEQWVGATCQLDANECEGK------------------------------ 430
            .||||:|.:.||.|.||.:|.|..||:|.||||..                              
  Fly   501 HGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLA 565

Human   431 --------------PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNG 481
                          ||:||..|:|..|.:.|.|..||.|:.|..|::||.|||::|.||.||||.
  Fly   566 ALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVND 630

Human   482 YQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCR 546
            |:|.|..||.||.||.:.||||:|||.:||.|.|:...|:|.||.|:||.|||...:.|.||||.
  Fly   631 YRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCL 695

Human   547 NGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAA--------- 602
            .| .|.|....|||.||.|..||:|...|..|....|.  :||.::.......|..         
  Fly   696 EG-HCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCN--EGCFANVSLATSATTTTTTTTTATT 757

Human   603 -------SGV-CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFR 659
                   ||: |..||.|.....|.| |.|..|.|||:|..|:::|...||||||.|:|      
  Fly   758 TRKMAKPSGLPCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLD------ 815

Human   660 CFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNG 724
                    |:                        .||.|.|..||.||.|..|...|.|..|.||
  Fly   816 --------GD------------------------GDFTCECMSGWTGKRCSERATGCYAGQCQNG 848

Human   725 GTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 789
            |||.           ||        |.:.:..|:                |.|..||.|..|...
  Fly   849 GTCM-----------PG--------APDKALQPH----------------CRCAPGWTGLFCAEA 878

Human   790 TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCP 854
            .:.|...||:|||.|..|..||||.||.||:|||||||::||...||..||||:|.|.||.|.||
  Fly   879 IDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICP 943

Human   855 PGRAGPRCQEVIGFGRSCWSRG-------TPFPHGSSWV-----------EDCNSCRCLDGRRDC 901
            |||.|.||:.::...:|.....       |......:|:           |:||:|.|.:|...|
  Fly   944 PGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRC 1008

Human   902 SKVWCGWKPCLLA---GQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEE------PPST 957
            :.:|||...|...   .:...||..|...:.|:......||..||...|:|.|.|      ||..
  Fly  1009 TNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRL 1073

Human   958 P----CLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDR--------LL 1010
            |    |.|....::.||||||:....:.|.:|.:|..:||.:|.|.|.:.:.:..        :|
  Fly  1074 PAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGML 1138

Human  1011 VLLCDRASSGASAVEVAVSFSPARD--LPDSSLIQG------------------AAHAIVAAITQ 1055
            ::|||..:.....||:.||.|...|  ||.:..:.|                  ..||.:||:| 
  Fly  1139 MVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALT- 1202

Human  1056 RGNSSLLLAVTEVKVETV-VTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRK----------- 1108
                    ::.|||:||. |..||...||:.||||.|.||....|.:.::|.::           
  Fly  1203 --------SIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNL 1259

Human  1109 -------RRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALP 1166
                   |.:|.:.:.|..||:......||....:.:....|.:      .:..|.|..|..|..
  Fly  1260 TPSLDALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAATGME------LSLNPAPELAASAAS 1318

Human  1167 GPAGHAAVR-------EDEEDEDLGRGEEDSLEAEKFLSHK 1200
            ..|.|.:..       |.|.|...|. ::....:.:.|.||
  Fly  1319 SSALHRSQPLFPPCDFERELDSSTGL-KQAHKRSSQILLHK 1358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JAG2NP_002217.3 MNNL 28..196 CDD:462222 67/176 (38%)
DSL 178..240 CDD:128366 29/61 (48%)
EGF_CA 307..345 CDD:238011 23/37 (62%)
EGF 351..381 CDD:394967 16/91 (18%)
EGF_CA 385..421 CDD:238011 19/35 (54%)
EGF_CA 423..458 CDD:238011 17/78 (22%)
EGF_CA 461..496 CDD:238011 20/34 (59%)
EGF_CA 500..534 CDD:238011 19/33 (58%)
EGF_CA 536..571 CDD:238011 16/34 (47%)
EGF_CA 636..671 CDD:238011 11/34 (32%)
EGF_CA 676..709 CDD:238011 8/32 (25%)
EGF 716..746 CDD:394967 10/29 (34%)
EGF_CA 757..787 CDD:238011 6/29 (21%)
EGF_CA 789..824 CDD:238011 18/34 (53%)
EGF_CA 827..863 CDD:238011 21/35 (60%)
VWC_out 872..943 CDD:214565 19/91 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1114..1139 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1238 13/52 (25%)
SerNP_524527.3 MNNL 83..238 CDD:462222 67/177 (38%)
DSL 220..282 CDD:128366 29/61 (48%)
EGF_CA 350..388 CDD:238011 23/37 (62%)
EGF_CA 490..526 CDD:238011 19/35 (54%)
EGF_CA 610..645 CDD:238011 20/34 (59%)
EGF_CA 647..683 CDD:238011 19/35 (54%)
EGF_CA 690..720 CDD:238011 15/30 (50%)
EGF_CA 798..833 CDD:238011 19/72 (26%)
EGF_CA 879..913 CDD:238011 18/33 (55%)
EGF_CA 916..952 CDD:238011 21/35 (60%)
VWC_out <993..1053 CDD:214565 17/59 (29%)

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