DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JAG2 and dsl-4

DIOPT Version :9

Sequence 1:	NP_002217.3	Gene:	JAG2 / 3714	HGNCID:	6189	Length:	1238	Species:	Homo sapiens
Sequence 2:	NP_001359594.1	Gene:	dsl-4 / 184563	WormBaseID:	WBGene00001106	Length:	368	Species:	Caenorhabditis elegans

Alignment Length:	407	Identity:	105/407 - (25%)
Similarity:	145/407 - (35%)	Gaps:	152/407 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   131 VIP-FQFAWPRSFTLIVEAWDWDNDTTPN-------------EELLIERVSHAGMINPEDRWKSL 181
            ||| |.|.:...||         ..|.||             |.|.:|::     :.|..|
Worm    57 VIPEFPFVFEEYFT---------RPTLPNVIFTISIYDINDEEPLGLEQI-----VVPLTR---- 103

Human   182 HFSGHVAH------LELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
            |||....|      |...:|..||||:.:.:|:.||:.|:|  ..:.||......|..|:.|..|
Worm   104 HFSNFTVHTKNDSFLHFAVRNVCDENWRTHSCSIFCKDRSD--SKFKCDDDDGYKCAPGYSGPNC 166

Human   241 KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCD 305
            .:..|...|: .||.|.|||:|.||.|:.|.:|:.|.|...|.||:.:
Worm   167 DKVDCPFNCH-NHGSCEVPGKCMCSQGFFGTYCEYCKPSTTCKHGAVL----------------- 213

Human   306 KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFE 370
              :|..|.|               .|.|.|.:||:|.|.:|.:....:.||.:|
Worm   214 --VNELGCH---------------PYTCRCFEGYAGDNGDKDDVCYYAKPCRHG----------- 250

Human   371 CHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNA 435
                             .|.||...:|        |||||||:.:.|..|:
Worm   251 -----------------NCVSNVTVSG--------GFECICPKAFGGRRCE-------------- 276

Human   436 FSCKNLIGGYYCDCIPGWKGINCHINVNDC--RGQCQHGGTCKDLVNGY-QCVCPRGFGGRHCEL 497
                        ..|..|          ||  .|.||:.|.| ..|:|. :|.|..||.|:|||.
Worm   277 ------------KRIARW----------DCSDEGYCQNKGVC-SFVDGISRCRCAVGFTGKHCER 318

Human   498 ERDE-CASSPCHSGGLC 513
            :..: |....|..|.:|
Worm   319 KTAKTCLKKKCREGFIC 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAG2	NP_002217.3	MNNL	28..102	CDD:284966
		DSL	178..240	CDD:279722	20/67 (30%)
		EGF_CA	307..345	CDD:238011	10/37 (27%)
		EGF	351..381	CDD:278437	3/29 (10%)
		EGF_CA	385..421	CDD:238011	12/35 (34%)
		EGF_CA	423..458	CDD:238011	2/34 (6%)
		EGF_CA	461..496	CDD:238011	15/37 (41%)
		EGF_CA	500..534	CDD:238011	4/15 (27%)
		EGF_CA	536..571	CDD:238011
		EGF_CA	636..671	CDD:238011
		EGF_CA	676..709	CDD:238011
		EGF	716..746	CDD:278437
		EGF_CA	757..787	CDD:238011
		EGF_CA	789..824	CDD:238011
		EGF_CA	827..863	CDD:238011
		VWC_out	872..943	CDD:214565
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1114..1139
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1238
dsl-4	NP_001359594.1	DSL	110..166	CDD:366627	17/57 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I8699
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920