Protein Alignment JAG2 and Jag2

DIOPT Version :10

• Sequence 1: NP_002217.3
• Gene: JAG2 / 3714
• HGNCID: 6189
• Length: 1238
• Species: Homo sapiens
• Sequence 2: NP_034718.2
• Gene: Jag2 / 16450
• MGIID: 1098270
• Length: 1247
• Species: Mus musculus
• Alignment Length: 1247
• Identity: 1121/1247 - (89%)
• Similarity: 1160/1247 - (93%)
• Gaps: 9/1247 - (0%)

Human     1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHD 65
            |||:|.|||||||||||.|.|||.|||||||||||||||||||||||||||||||||||||||.|
Mouse     1 MRARGWGRLPRRLLLLLVLCVQATRPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGRD 65

Human    66 ECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLV 130
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||:|.||.||||||
Mouse    66 ECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPPAGAAGDRARARSRTGGHQDPGLV 130

Human   131 VIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIR 195
            |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
Mouse   131 VIPFQFAWPRSFTLIVEAWDWDNDTTPDEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIR 195

Human   196 VRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 VRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPG 260

Human   261 ECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCIN 325
            ||||||||||:||||||||||||||||||||.|:|||||||||||||||||||||||.|||||||
Mouse   261 ECRCSYGWQGKFCDECVPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCIN 325

Human   326 AEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
            ||||||.|.|||||.|:|||:|||||.|||||||||||||||||||||||||:||||||||||||
Mouse   326 AEPDQYLCACPDGYLGKNCERAEHACASNPCANGGSCHEVPSGFECHCPSGWNGPTCALDIDECA 390

Human   391 SNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKG 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||
Mouse   391 SNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCLPGWKG 455

Human   456 INCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 520
            |||.||:|||.||||||||||||||||||||||||||||||||.|:||||||..||:||||.|||
Mouse   456 INCQININDCHGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYDKCASSPCRRGGICEDLVDGF 520

Human   521 HCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRV 585
            .||||:|.||..||||:||||||||.|||||||||||||||||:|||||||||||:.||||||||
Mouse   521 RCHCPRGLSGLHCEVDMDLCEPSPCLNGARCYNLEGDYYCACPEDFGGKNCSVPRDTCPGGACRV 585

Human   586 IDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGT 650
            |||||.:||....|.|.||:|||||.|||.|||||||||||||||||||||||||:|||||||||
Mouse   586 IDGCGFEAGSRARGVAPSGICGPHGHCVSLPGGNFSCICDSGFTGTYCHENIDDCMGQPCRNGGT 650

Human   651 CIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ 715
            ||||||:|||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mouse   651 CIDEVDSFRCFCPSGWEGELCDINPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ 715

Human   716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780
            ||||||||||||||||||||||||||||||||.:||||||:||||||||||||||.|||||||||
Mouse   716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCTIAKNSSCVPNPCVNGGTCVGSGDSFSCICRDG 780

Human   781 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDE 845
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   781 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDE 845

Human   846 INGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKP 910
            ||||||||||||:|||||||:.|.|.|||||..|||||||:|||||||||||.||||||||||||
Mouse   846 INGYRCSCPPGRSGPRCQEVVIFTRPCWSRGMSFPHGSSWMEDCNSCRCLDGHRDCSKVWCGWKP 910

Human   911 CLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEE--PPSTPCLPRSGHLDNNCARL 973
            |||:|||...|||||.||:|.|||.||||:||||.||||.|||  ||||||.|||.|||||||||
Mouse   911 CLLSGQPSDPSAQCPPGQQCQEKAVGQCLQPPCENWGECTAEEPLPPSTPCQPRSSHLDNNCARL 975

Human   974 TLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPD 1038
            ||.||||.|||||||||||||||:||||||.|.||||:|||||||||||||||||||||||||||
Mouse   976 TLRFNRDQVPQGTTVGAICSGIRALPATRAAAHDRLLLLLCDRASSGASAVEVAVSFSPARDLPD 1040

Human  1039 SSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCV 1103
            |||||..|||||||||||||||||||||||||||||.|||||||||||||..||||||||||:||
Mouse  1041 SSLIQSTAHAIVAAITQRGNSSLLLAVTEVKVETVVMGGSSTGLLVPVLCSVFSVLWLACVVICV 1105

Human  1104 WWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERP-------GGHKDVLYQCKNFTPPPRRA 1161
            |||||||||||||||||:||||||||||||||||||||       |||||:||||||||||||||
Mouse  1106 WWTRKRRKERERSRLPRDESANNQWAPLNPIRNPIERPGGSGLGTGGHKDILYQCKNFTPPPRRA 1170

Human  1162 DEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAV 1226
            .|||||||||.|..||||||:|.||:.||.|||||:||||||||..|.||||.||.|||||||||
Mouse  1171 GEALPGPAGHGAGGEDEEDEELSRGDGDSPEAEKFISHKFTKDPSCSLGRPARWAPGPKVDNRAV 1235

Human  1227 RSINEARYAGKE 1238
            ||..:.|.||:|
Mouse  1236 RSTKDVRRAGRE 1247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JAG2	NP_002217.3	MNNL	28..196	CDD:462222	161/167 (96%)
		DSL	178..240	CDD:128366	61/61 (100%)
		EGF_CA	307..345	CDD:238011	32/37 (86%)
		EGF	351..381	CDD:394967	27/29 (93%)
		EGF_CA	385..421	CDD:238011	35/35 (100%)
		EGF_CA	423..458	CDD:238011	33/34 (97%)
		EGF_CA	461..496	CDD:238011	32/34 (94%)
		EGF_CA	500..534	CDD:238011	23/33 (70%)
		EGF_CA	536..571	CDD:238011	31/34 (91%)
		EGF_CA	636..671	CDD:238011	32/34 (94%)
		EGF_CA	676..709	CDD:238011	32/32 (100%)
		EGF	716..746	CDD:394967	29/29 (100%)
		EGF_CA	757..787	CDD:238011	28/29 (97%)
		EGF_CA	789..824	CDD:238011	34/34 (100%)
		EGF_CA	827..863	CDD:238011	34/35 (97%)
		VWC_out	872..943	CDD:214565	57/70 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1114..1139		23/24 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1156..1238		61/81 (75%)
Jag2	NP_034718.2	MNNL	28..196	CDD:462222	161/167 (96%)
		DSL	178..240	CDD:128366	61/61 (100%)
		EGF_CA	307..345	CDD:238011	32/37 (86%)
		EGF	351..381	CDD:394967	27/29 (93%)
		EGF_CA	385..421	CDD:238011	35/35 (100%)
		EGF_CA	423..459	CDD:238011	34/35 (97%)
		EGF_CA	461..496	CDD:238011	32/34 (94%)
		EGF_CA	500..534	CDD:238011	23/33 (70%)
		EGF_CA	536..571	CDD:238011	31/34 (91%)
		EGF_CA	636..671	CDD:238011	32/34 (94%)
		EGF_CA	676..709	CDD:238011	32/32 (100%)
		EGF	716..746	CDD:394967	29/29 (100%)
		EGF_CA	757..787	CDD:238011	28/29 (97%)
		EGF_CA	<797..824	CDD:238011	26/26 (100%)
		EGF_CA	827..863	CDD:238011	34/35 (97%)
		VWC_out	872..943	CDD:214565	57/70 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1115..1148		28/32 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1167..1247		59/79 (75%)