DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JAG2 and jag2b

DIOPT Version :9

Sequence 1:	NP_002217.3	Gene:	JAG2 / 3714	HGNCID:	6189	Length:	1238	Species:	Homo sapiens
Sequence 2:	NP_571937.1	Gene:	jag2b / 140422	ZFINID:	ZDB-GENE-011128-3	Length:	1254	Species:	Danio rerio

Alignment Length:	1268	Identity:	743/1268 - (58%)
Similarity:	895/1268 - (70%)	Gaps:	79/1268 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    15 LLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQ 79
            |||.:|.:.::..|||||||.|:.||||||..|.|||.. |.::...|..||||||.:|||||||
Zfish    16 LLLTMWTKVSQSSGYFELQLIAVENVNGELWDGECCDST-RNSQDQRCVRDECDTYFKVCLKEYQ 79

Human    80 AKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTL 144
            ::||.||.|::|.|:|.|||||.|....|..:..:.         .|.|.::|||.||||||:||
Zfish    80 SEVTTTGQCTFGSGSTDVLGGNIFSFKTAKNSPSKT---------SDVGKIIIPFHFAWPRSYTL 135

Human   145 IVEAWDWDNDTTPN-EELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCN 208
            |:|||||||.|..| ||.||||..||.|:||.|.|:|:...|..||:|.:||||||||||.:.||
Zfish   136 ILEAWDWDNSTQNNGEENLIERHIHASMVNPGDHWQSIRHPGITAHIEYRIRVRCDENYYGSKCN 200

Human   209 KFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC 273
            |.||||:|:||||.||..||..|:|||||::|:.|:|||||||:||||.|||||:|:|||||:||
Zfish   201 KQCRPRDDYFGHYRCDPSGNIVCLDGWMGEDCRTAICKQGCNLIHGGCAVPGECKCNYGWQGQFC 265

Human   274 DECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338
            |||:|||||:||:||.||||.||.|||||||||||||||:||||.|||||:|:|||:|.|.||:|
Zfish   266 DECLPYPGCLHGTCVMPWQCTCEKNWGGLLCDKDLNYCGTHHPCVNGGTCMNSEPDEYNCACPEG 330

Human   339 YSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQ 403
            |||:|||.|||||.||||||||:|||||:|||||||.||.|||||.|:|||||:|||.||||:|.
Zfish   331 YSGKNCEIAEHACVSNPCANGGTCHEVPTGFECHCPPGWEGPTCAKDMDECASSPCAQGGTCIDL 395

Human   404 VDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ 468
            .:||||:||.||||.|||:|||||.||||:||.||||:||||:|||..||.|.||.||:|.|.||
Zfish   396 ENGFECVCPPQWVGKTCQIDANECMGKPCVNAHSCKNMIGGYHCDCFQGWAGQNCDINLNGCHGQ 460

Human   469 CQHGGTCKDLVN-GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPL 532
            ||:|.|||:||: ||.|.||.||.|.|||:.|::|||.||.:||.|..:.|.|.|.||..::|.|
Zfish   461 CQNGATCKELVHGGYHCQCPAGFVGLHCEVSRNKCASGPCQNGGRCHVILDSFVCECPSNYAGML 525

Human   533 CEVD----VDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGC---- 589
            |||:    .:.|||:||:|.|.||:|.||:|||||:|:.||.|...::.|....|:|||.|
Zfish   526 CEVESLSHPNPCEPNPCQNTALCYSLPGDFYCACPEDYEGKTCENRKDHCKMTPCQVIDSCTIAV 590

Human   590 GSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDE 654
            .|::..|......|.||||||||:|||||||:|.|:.||||||||||::||:..||||||||||.
Zfish   591 ASNSSDGGVRHINSNVCGPHGRCISQPGGNFTCTCELGFTGTYCHENVNDCVSNPCRNGGTCIDG 655

Human   655 VDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAY 719
            :.:|:||||.||||:||..|.|:|...||.:.|.|.||||||||.|.:|||||||||||.|||:.
Zfish   656 ISSFQCFCPDGWEGDLCSINVNECSRSPCKNGGHCVDLVNDFYCECANGWKGKTCHSRESQCDSS 720

Human   720 TCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGR 784
            ||||||||||.||.|||||||||:||||..||||:|...||:|||||||.|.:|:|||:|||||.
Zfish   721 TCSNGGTCYDHGDAFRCACPPGWEGSTCNTAKNSTCASGPCLNGGTCVGGGDTFTCICKDGWEGA 785

Human   785 TCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 849
            ||..|||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||:
Zfish   786 TCAQNTNDCNPHPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGF 850

Human   850 RCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLA 914
            ||.||.||.||:|||.||.|::|...|..|||||.|.|:||:|:|::|:.:|:||.||.|||||.
Zfish   851 RCVCPLGRTGPQCQEFIGIGKTCHYAGLQFPHGSRWEEECNTCQCVNGKVECTKVVCGRKPCLLP 915

Human   915 GQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPP---STPCLPRSGHLDNNCARLTLH 976
            |.|......||.|:.|||.....||.|||..||.|.:.|.|   .|.|.|.|.:||.:|||:||.
Zfish   916 GTPGRELHYCPGGRECLEHNFLTCLSPPCHQWGFCSSPETPPTLQTKCEPNSVYLDKSCARITLI 980

Human   977 FNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSL 1041
            ||||.:|.||||..:||.:|.:||||::|:|..|::|||.:.....|||||:||. ..:.|..|.
Zfish   981 FNRDKLPTGTTVENVCSELRYMPATRSLAKDHKLLVLCDLSYKNQDAVEVAISFQ-HDEQPSHSQ 1044

Human  1042 IQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWT 1106
            ||.||..||:.:::|.||:::|||.|||||..|| ......||||||....|||:.||::|||||
Zfish  1045 IQEAASTIVSTLSKRHNSTVMLAVIEVKVEMPVT-SQPVDYLVPVLCVVLCVLWVFCVIVCVWWT 1108

Human  1107 RKRRKERE-RSRLPREESANNQWAPLNPIRNPIERPGGHKD----VLYQCKNFTPPPRRADEALP 1166
            |||||||| |.|:|.|||.||||.||.|:..|     .|||    ...:.|....|.|..:..
Zfish  1109 RKRRKERERRERVPVEESVNNQWEPLRPVTRP-----QHKDNRDAQFERTKLMGSPDRTCNSG-- 1166

Human  1167 GPAGHAAVREDEEDEDLGRGEEDSL---------EAEKFLSHKFTKDPGR--------------- 1207
                     :||||.     |||.|         |..|....|::|...|
Zfish  1167 ---------DDEEDM-----EEDELELVEEWCGTEGGKHPVQKYSKSAARTKNGLICTTRSTSGS 1217

Human  1208 -SPG-RPAHWASGPKVDNRAVRSINEARYAGKE 1238
             ||. :.|:|......||.. :::|.|. ||:|
Zfish  1218 SSPSLKAAYWTGFSPKDNNC-KNVNNAT-AGQE 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAG2	NP_002217.3	MNNL	28..102	CDD:284966	45/73 (62%)
		DSL	178..240	CDD:279722	38/61 (62%)
		EGF_CA	307..345	CDD:238011	28/37 (76%)
		EGF	351..381	CDD:278437	24/29 (83%)
		EGF_CA	385..421	CDD:238011	25/35 (71%)
		EGF_CA	423..458	CDD:238011	25/34 (74%)
		EGF_CA	461..496	CDD:238011	22/35 (63%)
		EGF_CA	500..534	CDD:238011	15/33 (45%)
		EGF_CA	536..571	CDD:238011	20/38 (53%)
		EGF_CA	636..671	CDD:238011	22/34 (65%)
		EGF_CA	676..709	CDD:238011	20/32 (63%)
		EGF	716..746	CDD:278437	24/29 (83%)
		EGF_CA	757..787	CDD:238011	20/29 (69%)
		EGF_CA	789..824	CDD:238011	33/34 (97%)
		EGF_CA	827..863	CDD:238011	30/35 (86%)
		VWC_out	872..943	CDD:214565	35/70 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1114..1139		15/25 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1238		25/107 (23%)
jag2b	NP_571937.1	MNNL	28..101	CDD:284966	44/73 (60%)
		DSL	170..232	CDD:279722	38/61 (62%)
		EGF_CA	299..337	CDD:238011	28/37 (76%)
		EGF_CA	<346..374	CDD:238011	23/27 (85%)
		EGF_CA	377..413	CDD:238011	25/35 (71%)
		EGF_CA	415..450	CDD:238011	25/34 (74%)
		EGF_CA	458..489	CDD:238011	19/30 (63%)
		EGF_CA	493..527	CDD:238011	15/33 (45%)
		EGF_CA	535..569	CDD:238011	20/33 (61%)
		EGF_CA	637..672	CDD:238011	22/34 (65%)
		EGF_CA	675..710	CDD:238011	21/34 (62%)
		EGF	756..786	CDD:278437	20/29 (69%)
		EGF_CA	790..825	CDD:238011	33/34 (97%)
		EGF_CA	828..864	CDD:238011	30/35 (86%)
		VWC_out	873..944	CDD:214565	35/70 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327152
Domainoid	1	1.000	300	1.000	Domainoid score	I7494
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1677
Inparanoid	1	1.050	1649	1.000	Inparanoid score	I729
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		otm27030
orthoMCL	1	0.900	-	-		OOG6_105778
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.170