Protein Alignment JAG2 and jag2

DIOPT Version :10

• Sequence 1: NP_002217.3
• Gene: JAG2 / 3714
• HGNCID: 6189
• Length: 1238
• Species: Homo sapiens
• Sequence 2: XP_012824896.2
• Gene: jag2 / 100497180
• XenbaseID: XB-GENE-485160
• Length: 1224
• Species: Xenopus tropicalis
• Alignment Length: 1242
• Identity: 790/1242 - (63%)
• Similarity: 948/1242 - (76%)
• Gaps: 41/1242 - (3%)

Human     7 GRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYV 71
            |.|....|:||.||||.:...|||||||.:|:|.|||||:|.||| |.::.:...||.||||||:
 Frog     9 GHLSVLALVLLTLWVQVSHSTGYFELQLISLKNANGELLNGECCD-DIKSAQNLDCGRDECDTYL 72

Human    72 RVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQF 136
            :|||||:|||:||||||:||.|.|.|||||:.||......|        .....:.|.:.|||||
 Frog    73 KVCLKEFQAKITPTGPCNYGSGFTSVLGGNTIYLNKYNHQG--------KSNPSESGRITIPFQF 129

Human   137 AWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDEN 201
            ||.||||||:|||||||||..:|:|||:||::||:.:|||:|..|..:||||..:::|||:||||
 Frog   130 AWTRSFTLILEAWDWDNDTKVDEDLLIDRVTYAGVTSPEDQWTLLPLTGHVAQFDVKIRVKCDEN 194

Human   202 YYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY 266
            ||.:.|||||||||||.||||||..|.||||:||||.|||:|:|||||:||||||||||||:|.|
 Frog   195 YYGSMCNKFCRPRNDFVGHYTCDSNGKKACMEGWMGAECKQAICKQGCDLLHGGCTVPGECKCHY 259

Human   267 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQY 331
            ||||.:|.|||||||||||||.|||.|.||||||||||:|||||||:||||.|||||:|.|||:|
 Frog   260 GWQGLYCSECVPYPGCVHGSCQEPWDCKCETNWGGLLCNKDLNYCGTHHPCLNGGTCMNTEPDKY 324

Human   332 RCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAA 396
            .|.|||||||:|||.|||||.||||||.|.||||.||||||||.||:|.|||:|||||||||||:
 Frog   325 YCACPDGYSGQNCEIAEHACASNPCANDGVCHEVSSGFECHCPPGWTGTTCAVDIDECASNPCAS 389

Human   397 GGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHI- 460
            ||.|.|.::|||||||.||.|.|||||||||||||||||::|:||||.|:|.|:|||.|:||||
 Frog   390 GGECKDLINGFECICPPQWAGTTCQLDANECEGKPCLNAYACRNLIGRYFCHCLPGWTGLNCHIK 454

Human   461 NVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCP 525
            ..:||.||||:||.|||.||||:|:|||||.|::||:|.::|||.||.:||.|||..:.|.|||.
 Frog   455 KSDDCHGQCQNGGICKDKVNGYRCICPRGFVGKNCEIELNKCASKPCQNGGTCEDHVNTFRCHCA 519

Human   526 QGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGC- 589
            .|:||.|||:.||||||:||:|.||||||:|||||||.||:.||||:..::.|...:|::||.|
 Frog   520 PGYSGTLCELTVDLCEPNPCQNKARCYNLDGDYYCACSDDYDGKNCTHLKDHCKNSSCKIIDSCT 584

Human   590 ---GSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC 651
               .::|........:|.||||||||:|||||||:|.||.||||.||||||:||||.||:|||||
 Frog   585 IAISTNATQEGIRYISSNVCGPHGRCISQPGGNFTCSCDRGFTGAYCHENINDCLGTPCKNGGTC 649

Human   652 IDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 716
            .||:|:|:||||:||.||.||.|.|||.|:||.:.|||.||||||.|.|.:|||||||||||:||
 Frog   650 TDEIDSFKCFCPNGWGGEFCDINYNDCSPNPCQNDGRCIDLVNDFACECKNGWKGKTCHSREYQC 714

Human   717 DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGW 781
            ||.||||||||||:||:|.|.|..||:||||.:|||||||||||.|||||||:|.||||:|::||
 Frog   715 DANTCSNGGTCYDTGDSFHCLCCSGWEGSTCNLAKNSSCLPNPCENGGTCVGNGDSFSCMCKEGW 779

Human   782 EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEI 846
            ||||||.|||||||.||||||||||||||||||||||||||||||||||||||||||||||:|||
 Frog   780 EGRTCTENTNDCNPYPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCIDEI 844

Human   847 NGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPC 911
            |||||:||.||||.|||||||.|||||.:|..:|||..|||:||||.||||..:|:|.|||.|||
 Frog   845 NGYRCTCPSGRAGLRCQEVIGLGRSCWLKGMQYPHGGKWVEECNSCYCLDGGVECTKTWCGPKPC 909

Human   912 LLAGQPEALSAQCPLGQRCLEK-APGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTL 975
            ||....:  .::||.||.|..: .|.:|.:|||..||||.|..|.:..|||.|.:||:||||:||
 Frog   910 LLEHSKD--KSRCPRGQDCEARVTPFKCFQPPCREWGECSAPLPAAVKCLPDSDYLDSNCARITL 972

Human   976 HFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSS 1040
            .||.|.|||||||..:||.||.||:.|.|:::|.||:|||.:||...|:|||:||....|..|:|
 Frog   973 IFNSDKVPQGTTVENVCSEIRYLPSLRTVSKERQLVVLCDVSSSMEKAIEVAISFISQTDDKDNS 1037

Human  1041 LIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWW 1105
            |||.||:.||.|||:|.||:::||||||||||:|.|.|.:..|:||||..||::|:.|:::||||
 Frog  1038 LIQNAANTIVNAITKRQNSTVMLAVTEVKVETMVVGSSHSDYLIPVLCTVFSIVWITCIIICVWW 1102

Human  1106 TRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAG 1170
            .|||||||||.  .:|||||||...||||.|||..|...||:.|:||||....:|..:
 Frog  1103 MRKRRKERERR--CQEESANNQRELLNPIWNPIGAPYNQKDIHYECKNFLSHQKRTYD------- 1158

Human  1171 HAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKD---------PGRSPGRPAHWASGPKVDNRAV 1226
               ..|:|::|::|   |:..|.:|.||....|.         ...||.:..|..|..|:|||.|
 Frog  1159 ---TEEEEKEEEVG---EEVTEVDKCLSQTCPKTLTSKGDVDCSESSPVKKPHRTSDYKMDNRCV 1217

Human  1227 RSINEAR 1233
            :::|.:|
 Frog  1218 KNVNTSR 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JAG2	NP_002217.3	MNNL	28..196	CDD:462222	94/167 (56%)
		DSL	178..240	CDD:128366	41/61 (67%)
		EGF_CA	307..345	CDD:238011	29/37 (78%)
		EGF	351..381	CDD:394967	23/29 (79%)
		EGF_CA	385..421	CDD:238011	26/35 (74%)
		EGF_CA	423..458	CDD:238011	25/34 (74%)
		EGF_CA	461..496	CDD:238011	22/34 (65%)
		EGF_CA	500..534	CDD:238011	18/33 (55%)
		EGF_CA	536..571	CDD:238011	26/34 (76%)
		EGF_CA	636..671	CDD:238011	25/34 (74%)
		EGF_CA	676..709	CDD:238011	22/32 (69%)
		EGF	716..746	CDD:394967	21/29 (72%)
		EGF_CA	757..787	CDD:238011	23/29 (79%)
		EGF_CA	789..824	CDD:238011	33/34 (97%)
		EGF_CA	827..863	CDD:238011	31/35 (89%)
		VWC_out	872..943	CDD:214565	35/71 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1114..1139		15/24 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1156..1238		22/87 (25%)
jag2	XP_012824896.2	MNNL	29..189	CDD:462222	94/168 (56%)
		DSL	171..233	CDD:128366	41/61 (67%)
		EGF_CA	300..338	CDD:238011	29/37 (78%)
		EGF	344..372	CDD:394967	22/27 (81%)
		EGF_CA	378..414	CDD:238011	26/35 (74%)
		EGF_CA	416..451	CDD:238011	25/34 (74%)
		EGF_CA	457..490	CDD:238011	22/32 (69%)
		EGF_CA	494..528	CDD:238011	18/33 (55%)
		EGF_CA	531..566	CDD:238011	27/34 (79%)
		EGF_CA	634..669	CDD:238011	25/34 (74%)
		EGF_CA	674..707	CDD:238011	22/32 (69%)
		EGF_CA	715..745	CDD:238011	21/29 (72%)
		EGF_CA	755..785	CDD:238011	23/29 (79%)
		EGF_CA	787..822	CDD:238011	33/34 (97%)
		EGF_CA	825..861	CDD:238011	31/35 (89%)
		VWC_out	870..940	CDD:214565	35/71 (49%)