Protein Alignment GEFmeso and ARHGEF6

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_016885464.1
• Gene: ARHGEF6 / 9459
• HGNCID: 685
• Length: 807
• Species: Homo sapiens
• Alignment Length: 946
• Identity: 195/946 - (20%)
• Similarity: 351/946 - (37%)
• Gaps: 281/946 - (29%)

  Fly   346 EFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDL------DPRAELIEAVNKT----LVNKP 400
            |..|.:|.:..|.::.||..|......::.:.||.||      ......:.||||.    |..:|
Human    54 EKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERP 118

  Fly   401 LVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEE--ANKLSAESL- 462
            ..||||.:.|:|         ::|...||.:||:.|     |....:..|:.|  :::|..::.
Human   119 CGRSSSLSAANT---------SQTNPQGAVSSTVSG-----LQRQSKTVEMTENGSHQLIVKARF 169

  Fly   463 -------DRLTDIKPK--FAARLSE----LARLNNRPLSSSSICSTSSSSSSGSDQLL-----NG 509
                   |.|:..|..  :..|:.|    ...||.|.....|.......||.|...||     ||
Human   170 NFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSDGVSLLLPGLECNG 234

  Fly   510 KLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCL----------EIVDSERSFVEDLGQVI 564
            .:.|...|.    |..|:..|.    |.|:...|...|          .|:|:|:.:.::|..::
Human   235 AISAHHNLC----LPGSKRPLS----PKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLL 291

  Fly   565 KGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDP---GRIARCFIDLRDGF-D 625
            ..||:..:....|...|:..|..|.||:..|...|.|.|....:.|   .::..|.:.|...| .
Human   292 VTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKS 356

  Fly   626 VYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHR-------LPLGSYLLKPVQRILKYHL 683
            :|..||.::|.|:::||:     |:..|    ::.::::       |.|.:.|.||..|:.||..
Human   357 MYLAYCANHPSAVNVLTQ-----HSDEL----EQFMENQGASSPGILILTTNLSKPFMRLEKYVT 412

  Fly   684 LLDSLRKHC-----DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLG 743
            ||..|.:|.     |.:::::|.|..:.:......::::::.:.::  ||..:..|.|.::..||
Human   413 LLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQI--LSEPIQAWEGEDIKNLG 475

  Fly   744 ELRQEGLLMEQH-----NKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSF 803
            .:.....:|.|:     .::|.::||:.:||                     |||.
Human   476 NVIFMSQVMVQYGACEEKEERYLMLFSNVLI---------------------MLSA--------- 510

  Fly   804 YVIPFDEPR-----HQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQL-GNEEDRTPD 862
                  .||     :|.|:.             |.|.::.:|| .:...:..::: ||..:|.
Human   511 ------SPRMSGFIYQGKIP-------------IAGTVVTRLD-EIEGNDCTFEITGNTVERI-- 553

  Fly   863 RSTWKWSLHSGSNST-PTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEE---- 922
                  .:|..:|.. ..:||:.|...|..  ...|...:.:.::.|:..:|::|.....:
Human   554 ------VVHCNNNQDFQEWLEQLNRLIRGP--ASCSSLSKTSSSSCSAHSTFSQSFSSTGQPRGP 610

  Fly   923 ----------SISQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQD 977
                      |:|..:|:.||            :.:||:.|::|
Human   611 LEPPQIIKPWSLSCLRPAPPL------------RPSAALGYKER--------------------- 642

  Fly   978 AKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEAEREREQDE---- 1038
                                        .|| .|||.|||...:..|....:.||:..::|
Human   643 ----------------------------MSY-ILKESSKSPKTMKKFLHKRKTERKPSEEEYVIR 678

  Fly  1039 DSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSS 1103
            .|.|:|   :.|....|.       ::.|...      ||.::...|:|:.           ||.
Human   679 KSTAAL---EEDAQILKV-------IEAYCTS------ANFQQGHGSSTRK-----------DSI 716

  Fly  1104 SSTVLKITES--TEELRPDGEIELAQEAATLDESTQDQYYSPDHETELLSPAEKSKRDAQIVLDL 1166
            ...:|...|.  .||.|.:|:..:.      ::|..|..|:...|...|.  :::||..|.:.:.
Human   717 PQVLLPEEEKLIIEETRSNGQTIME------EKSLVDTVYALKDEVRELK--QENKRMKQCLEEE 773

  Fly  1167 LKNSKEFERIYNKQQKRRESPVSPVSPDISRGPILP 1202
            ||:.::.|::..:..|:.:..:...|.  |:..|||
Human   774 LKSRRDLEKLVRRLLKQTDECIRGESS--SKTSILP 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	44/179 (25%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	24/154 (16%)
ARHGEF6	XP_016885464.1	CH_alphaPIX	1..117	CDD:409114	16/62 (26%)
		RhoGEF67_u1	115..160	CDD:465201	16/58 (28%)
		SH3_alphaPIX	162..219	CDD:212993	10/56 (18%)
		RhoGEF	269..446	CDD:238091	44/185 (24%)
		PH_Cool_Pix	477..574	CDD:269932	26/154 (17%)
		RhoGEF67_u2	607..705	CDD:465200	29/175 (17%)
		betaPIX_CC	716..800	CDD:465158	18/91 (20%)