DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and CDC24

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_009359.1	Gene:	CDC24 / 851190	SGDID:	S000000039	Length:	854	Species:	Saccharomyces cerevisiae

Alignment Length:	794	Identity:	163/794 - (20%)
Similarity:	290/794 - (36%)	Gaps:	214/794 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 PTPSATKAK---EFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVN 398
            |.||||...   :.|.::|::..|.:    |.:.|...:||.:..  .|.|..:|....::.|..
Yeast    18 PKPSATSISIPMQNVMNKPVTEQDSL----FHICANIRKRLEVLP--QLKPFLQLAYQSSEVLSE 76

  Fly   399 K---------------------------PLVRSSSAACASTICSSPLLTY-----ARTKSLGAKA 431
            :                           |.:||||.:.|:::.|...::|     :.|.::....
Yeast    77 RQSLLLSQKQHQELLKSNGANRDSSDLAPTLRSSSISTATSLMSMEGISYTNSNPSATPNMEDTL 141

  Fly   432 STLGGGV-PIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICST 495
            .|...|: ||.: ..:.:.:|.:..:..|........:||:|  :|..:|.      ....:|..
Yeast   142 LTFSMGILPITM-DCDPVTQLSQLFQQGAPLCILFNSVKPQF--KLPVIAS------DDLKVCKK 197

  Fly   496 S----------------SSSSSGSDQLLNGKLMATSYLASVESLAESE--------------NEL 530
            |                ....:.||...|........|..||:|..|.              |..
Yeast   198 SIYDFILGCKKHFAFNDEELFTISDVFANSTSQLVKVLEVVETLMNSSPTIFPSKSKTQQIMNAE 262

  Fly   531 GDQHHPPAMSVLE-----KTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIE 590
            ....|.|..|..:     |...|.|.:||.:|.|| :::..|.|...:...:..:||.:||.|:.
Yeast   263 NQHRHQPQQSSKKHNEYVKIIKEFVATERKYVHDL-EILDKYRQQLLDSNLITSEELYMLFPNLG 326

  Fly   591 EIYEFNSMLLQRL-INTGRDPG--RIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYS 652
            :..:|....|..| ||...:|.  ||...|:..:..|.:|..:......||..|:..|   |...
Yeast   327 DAIDFQRRFLISLEINALVEPSKQRIGALFMHSKHFFKLYEPWSIGQNAAIEFLSSTL---HKMR 388

  Fly   653 LLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC----DVKEVVEAHVIMRQVAHNIDQ 713
            :..|.:.::.::|.|.|:|.|||||:.:|.||:..|....    :.||:..|..|.:.:|.:|::
Yeast   389 VDESQRFIINNKLELQSFLYKPVQRLCRYPLLVKELLAESSDDNNTKELEAALDISKNIARSINE 453

  Fly   714 VKRKQEQQSRVKELSGILDGWLGPELTVLGEL-----------------RQEGLLMEQHNKQRLV 761
            .:|:.|....||:|.|.:..|.|..::..|||                 .:|   .|.:..::::
Yeast   454 NQRRTENHQVVKKLYGRVVNWKGYRISKFGELLYFDKVFISTTNSSSEPERE---FEVYLFEKII 515

  Fly   762 LLF--------ATMLIITKQKEDG-------------------RLQFKTYISQNNLMLSEHLP-- 797
            :||        |:.||:.|:....                   ..:.....|.||:.||....
Yeast   516 ILFSEVVTKKSASSLILKKKSSTSASISASNITDNNGSPHHSYHKRHSNSSSSNNIHLSSSSAAA 580

  Fly   798 ---------------GEPTSFYVIPFDEPRHQIK-----------LTARNRDQKRIWTQHIKGVM 836
                           ...:|.:.:..:||:..::           :...||.....| :.||
Yeast   581 IIHSSTNSSDNNSNNSSSSSLFKLSANEPKLDLRGRIMIMNLNQIIPQNNRSLNITW-ESIK--- 641

  Fly   837 LEKLDIPMRAK-------------ELVYQLGNEEDRT---PDRSTWKWSLHSGSNSTPTYLERRN 885
             |:.:..::.|             :|::.|.||:.:.   ...||...:..|.|..:||  ...|
Yeast   642 -EQGNFLLKFKNEETRDNWSSCLQQLIHDLKNEQFKARHHSSTSTTSSTAKSSSMMSPT--TTMN 703

  Fly   886 ACRRSEIRQRNSKF----------------KRKTVANSSSFDSFNESL-EQEEESISQAKPSKPL 933
            .......||.:...                ||:|  .||||:|..:|: |..:.||.::.....:
Yeast   704 TPNHHNSRQTHDSMASFSSSHMKRVSDVLPKRRT--TSSSFESEIKSISENFKNSIPESSILFRI 766

  Fly   934 ARNNSLDDTALQKL 947
            :.||:.::|:..::
Yeast   767 SYNNNSNNTSSSEI 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	50/171 (29%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	38/216 (18%)
CDC24	NP_009359.1	CDC24	156..242	CDD:399412	15/93 (16%)
		RhoGEF	282..453	CDD:214619	50/174 (29%)
		PH_Scd1	455..667	CDD:270066	34/219 (16%)
		PB1	779..853	CDD:214770	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99810
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940