Protein Alignment GEFmeso and Plekhg1

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001177928.1
• Gene: Plekhg1 / 679812
• RGDID: 1583676
• Length: 1380
• Species: Rattus norvegicus
• Alignment Length: 1509
• Identity: 324/1509 - (21%)
• Similarity: 554/1509 - (36%)
• Gaps: 508/1509 - (33%)

  Fly   398 NKPLVRSSSAACAST-------------ICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQL- 448
            ::|:...|:::.||:             :.:|.|..:.:.|..||        :.::|..|:..
  Rat     7 DRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGA--------IKLELVPAQPFS 63

  Fly   449 -AELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLM 512
             :||::.|.....::|.:.:.:|:...|:.    .|..|.      :|:.|::|
  Rat    64 SSELQKDNPAGPPNMDGVGEKQPRAPWRVD----TNGTPQ------TTADSATS----------- 107

  Fly   513 ATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACL 577
                                    |.:..:::...||:::||::|:||..:::.||      ||:
  Rat   108 ------------------------PKLLYVDRVVQEILETERTYVQDLKSIVEDYL------ACI 142

  Fly   578 R--------VDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSY 634
            |        .::...||.||::||.|||.|||.|.|...||..||.||:...:.|.:||.|||:|
  Rat   143 RDQTKLPLGTEDRAALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNY 207

  Fly   635 PEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKE--- 696
            |.::::||:.::...........|:.|:|.|||||||||||||||||||||..:..|.| |:
  Rat   208 PRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLD-KDTEG 271

  Fly   697 ---VVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNK- 757
               |::|...|::||.:|:.:|||.|...|::|:..:|..|.||:||..|||..||....|..|
  Rat   272 YDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKN 336

  Fly   758 QRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNR 822
            :|.:.|...:|:|||::|| ...:|.:|...||||.|.:|.||.||.|..:..|:.|..:.|:::
  Rat   337 ERTLFLLDKLLLITKKRED-TFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKSPKLQHTVQAKSQ 400

  Fly   823 DQKRIWTQHIKGVMLEK--LDIPMRAKELVYQLGNEEDRTPDRSTWKWSLH--------SGSNST 877
            .:||:|..|:|.::||.  ..||.:||:.:.::.              ::|        .|...|
  Rat   401 QEKRLWILHLKRLILENHAAKIPAKAKQAILEMD--------------AIHHPGFCYDPKGEVKT 451

  Fly   878 PTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNSLDDT 942
            |.........|:||...|:.|. .||...:......:     .|||.||...:.|..||....:.
  Rat   452 PCGSAPHRLRRKSEPSSRSHKV-LKTSETAQDIQKVS-----REESSSQLTSAVPAQRNRQPGNA 510

  Fly   943 ALQKL---AAAMRYRKRDAAVKE----ETKTPVKE-----------PCKCDQD------AKQDER 983
            |:..:   ..::|....|..:::    ..:||.:.           |.....|      .:::..
  Rat   511 AVLNMLRGGGSVRGLWMDHHIQQPFFPSRRTPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENTS 575

  Fly   984 IEPCSC----------------ILRDQRSRSAKSQSPV---------FSYKALKERSKSVPRIGG 1023
            ..|||.                |:|...|....:..|.         ..|...:|...| |:.||
  Rat   576 SRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRLRDSDGSQYCPGREMQNS-PQPGG 639

  Fly  1024 ------------------------FSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKGFFEV 1064
                                    .|.::......::||..::..:.|:..:..:.|....|.:
  Rat   640 QGGMTPFGSSVELTIDDIDHVYDNISFEDLKLMVAKRDETESSFSKSSRDSVRPKSTPELAFSK- 703

  Fly  1065 KQYNHKTMPKKIANLKKQRSSTTKSCS----RFYMDLSE---------------FDSSS------ 1104
            :|.:|.|   ...:.||:.:|:.:..|    ..:.::.|               |..||
  Rat   704 RQASHST---SSLHSKKETASSGQEASNQSIHEHQEVEENIYDTIGLPDPPSLNFQRSSLQQPKR 765

  Fly  1105 STVLKITES---TEELRPDGEIELAQEAATLDESTQDQYYSPDHETELLSPAEKSKRDAQIVLDL 1166
            ||.|.:...   .:.|||    .::|:.....|.....:..|. :|:.||....|.|....:.|.
  Rat   766 STFLGLEADFACCDSLRP----FVSQDRLQFSEDDISYHQGPS-DTDYLSLLYDSPRCNLPIADK 825

  Fly  1167 L---KNSKEFERIYN--------KQQKRRESPVS--PVSPD-------------ISR-------- 1197
            .   |.|:|.:.|:|        .:.|.|:..::  |||.|             :||
  Rat   826 TLSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDVPERLYVESTQELSRDAGRATSM 890

  Fly  1198 -----------------------------------GPILP------------------------P 1203
                                               |..|.                        |
  Rat   891 LALPGSQTFLTPGESRVVRASRANCSLEDDLISTEGSFLSLNQLSLVSDEPSEDNPYDLASCSLP 955

  Fly  1204 PRPPSRSPPPLELEEQEKKPV-------------------------EEVDSVSEEPIYETLLRNV 1243
            ...|....|.:|:.::.|..|                         |:..|....||::.|:..:
  Rat   956 QTDPENPDPRMEITDKTKSRVFMMARQYSQKIKKVNQLLKVKSPELEQPLSSQHRPIHKDLVAIL 1020

  Fly  1244 HVPYKFSPVLGR--AKSSQI----------LKKR-----SKTAPAASRPESDYVTLVYSPEGVLQ 1291
            ....:..|.:|.  |:.||:          ||.:     |...||..||.|       .|:  :|
  Rat  1021 EEKRQGGPAIGARIAEYSQLYDQIVFRETPLKSQKDGWTSTQEPALHRPAS-------PPQ--VQ 1076

  Fly  1292 RVGEEVVQRDSCSSSTTSTSSNGSGSTLKRDSQSTVINLLMEAAQEHESRPLPKNSVSGSESSLL 1356
            ..||:.:...|.|:...:..|    ...::||:|              ..|:...|:    :.::
  Rat  1077 GAGEDWLWHSSYSNREVADFS----PQTEQDSKS--------------KYPVTLESI----TKIM 1119

  Fly  1357 PRALKSIDNLSMAFGRSNRPPERRVSD-----VSEMCRQSVL----HRQ-----------GSEAV 1401
            ||.|.:..::          |..:.||     |.:.|  ||:    |::           |.:|:
  Rat  1120 PRQLSAACSV----------PSLQGSDPLLGSVQQRC--SVVVSQPHKENSGQGHLYNSLGRKAI 1172

  Fly  1402 GERMAHVDYADP---------KALFGLGVLNHSERDSVFSLTSSS------------SDSMCEQQ 1445
            ..::.  .|:.|         |:|..:...:.:|:..:.||..|.            :||..:..
  Rat  1173 SAKLQ--PYSRPQSSSSVLINKSLDSINYPSETEKKQLLSLQKSPRGASQQDLLSGLADSCQQDT 1235

  Fly  1446 RKRSGVGATFEYEQQV--------------EDSLENDFRDSAIYSDDN-EKRSGDYDVHL----- 1490
            .|:|.:  |.:..|:|              ..:..::|:::....||. |.:|.:.:|.|
  Rat  1236 GKQSDL--TLQDSQKVLVVNRNLPLSAQIASQNYFSNFKETEGDEDDYVEIKSEEDEVRLDLSPR 1298

  Fly  1491 -RRPSSPPPPPP-----------------PLGPRPHQPPQI---------------APKPSKDQL 1522
             .|.|.|..|.|                 |:..|...||.:               .|.|::..:
  Rat  1299 RNRKSDPKIPDPDCSDNICRHNTPYSLKEPVSGRLGLPPYLTACKDSDKLNDYLWRGPSPNQQNI 1363

  Fly  1523 IQQRSGVIVCQSAS 1536
            :|.......|.|:|
  Rat  1364 VQSLREKFQCLSSS 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	74/177 (42%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	56/151 (37%)
Plekhg1	NP_001177928.1	RhoGEF	116..290	CDD:459876	74/180 (41%)
		PH_PLEKHG1_G2_G3	272..417	CDD:270063	55/145 (38%)