DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and PLEKHG2

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_011525534.1	Gene:	PLEKHG2 / 64857	HGNCID:	29515	Length:	1387	Species:	Homo sapiens

Alignment Length:	925	Identity:	239/925 - (25%)
Similarity:	367/925 - (39%)	Gaps:	236/925 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 SVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERAC--LRVDELQILFANIEEIYEFNSMLLQR 602
            |.||:...|||::||::|.||..:::.||....:...  |.|:::..||||||:||||:|.||:.
Human   102 SRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 166

  Fly   603 LINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPL 667
            |.|:. ..|.||.||:...:.||:||.||.:||.:::||.:|..:......|...|..|:|.|||
Human   167 LENSS-SAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPL 230

  Fly   668 GSYLLKPVQRILKYHLLLDSLRKH------CDVKEVV-EAHVIMRQVAHNIDQVKRKQEQQSRVK 725
            .|:|||||||||||||||..|.||      ...:|:| ||.|.|..||..|:.:|||||..:|::
Human   231 QSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQ 295

  Fly   726 ELSGILDGWLGPELTVLGELRQEGLLM-------EQHNKQRLVLLFATMLIITKQKEDG-RLQFK 782
            |:...|.||.||||:..|||..||...       .....:||:.||:.||::.|::  | ...:|
Human   296 EVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRR--GLEYTYK 358

  Fly   783 TYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEK--LDIPMR 845
            .:|...||.:||. |.:|..|.|.....|:|:..|.|:|:::||:|...::.:..|.  ..||.:
Human   359 GHIFCCNLSVSES-PRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAK 422

  Fly   846 AKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSF 910
            ||:::  |.|             |||....|.|.
Human   423 AKQVL--LEN-------------SLHCAPKSKPV------------------------------- 441

  Fly   911 DSFNESLEQEEESISQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEP-CKC 974
                  ||.....:...:|....:......:||.....:.:|..:|.:       .|||:| ...
Human   442 ------LEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQS-------EPVKDPYVMF 493

  Fly   975 DQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEAEREREQDED 1039
            .|:||..              .:.|.|:..::.       .:|.|.:.|.:..|:.|
Human   494 PQNAKPG--------------FKHAGSEGELYP-------PESQPPVSGSAPPEDLE-------- 529

  Fly  1040 SAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKKQR-----SSTTKSCSRFYMDLSE 1099
                 ....|.|....|              ::.::|..|..||     ..:|....:|..| |:
Human   530 -----DAGPPTLDPSGT--------------SITEEILELLNQRGLRDPGPSTHDIPKFPGD-SQ 574

  Fly  1100 FDSSSSTV----LKITESTEELRPDGEIELAQEAATLDESTQDQYYSPDHETELLSPAEKSKRDA 1160
            ....|.|:    |...:|:|      |.|..:|...:||...    ||.|..|.|..:..::..:
Human   575 VPGDSETLTFQALPSRDSSE------EEEEEEEGLEMDERGP----SPLHVLEGLESSIAAEMPS 629

  Fly  1161 QIVLDLLKNSKEFERIYNK---QQKRRESPVSPVSPDISRGPILP-----PPRPPSRSPPPLELE 1217
            ...|..:.:......|.::   .:..|...:|.:| |:...|.||     |..|...|.|.|..:
Human   630 IPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDIS-DVFEMPCLPAIPSVPNTPSLSSTPTLSCD 693

  Fly  1218 EQEKKPVEEVDSVSEEPIYETLLRNVHVPYKFSPVLGRAKSSQILKKRSKTAPAASRPESDYVTL 1282
            ...:.|::|   .:|.|.....|.:...|.|    ||...|.      .|..|........:..
Human   694 SWLQGPLQE---PAEAPATRRELFSGSNPGK----LGEPPSG------GKAGPEEDEEGVSFTD- 744

  Fly  1283 VYSPEGVLQRVG--EEVVQRDSCSSSTTSTSSNGSGSTLKRDSQSTVINLLMEAAQEHE-SRP-- 1342
             :.|:.|.|..|  :|:..| |||.                      |....:|.::.: :||
Human   745 -FQPQDVTQHQGFPDELAFR-SCSE----------------------IRSAWQALEQGQLARPGF 785

  Fly  1343 ------LPKNSVSGSESSLLPRALKSIDNLSMAFGRSNRP-PERRVSDVSEMCRQSVLHRQGSEA 1400
                  |..:.:.|...|                |::..| .||..|.|.|:.|          .
Human   786 PEPLLILEDSDLGGDSGS----------------GKAGAPSSERTASRVRELAR----------L 824

  Fly  1401 VGERMAHVDYADPKA 1415
            ..||:..:..|:.:|
Human   825 YSERIQQMQRAETRA 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	78/173 (45%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	54/153 (35%)
PLEKHG2	XP_011525534.1	RhoGEF	107..283	CDD:279015	78/176 (44%)
		PH_PLEKHG1_G2_G3	264..414	CDD:270063	54/152 (36%)
		PH	<338..410	CDD:278594	24/74 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4843
eggNOG	1	0.900	-	-		E1_KOG3518
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5413
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41567
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.890