DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and PLEKHG1

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001316727.1	Gene:	PLEKHG1 / 57480	HGNCID:	20884	Length:	1444	Species:	Homo sapiens

Alignment Length:	1341	Identity:	329/1341 - (24%)
Similarity:	522/1341 - (38%)	Gaps:	387/1341 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 LEEANKLSAESLDRLTDI-KPKFAARLSELARLNNRPLSSS----SICSTSSSSSS-------GS 503
            :.:.::|..|....:|.: .||..||.|....|....||.|    |..|||||:||       ||
Human    25 ITDGHQLRLEVPSAVTKVPHPKTTARRSCPQELKTMELSDSDRPVSFGSTSSSASSRDSHGSFGS 89

  Fly   504 D-----------------------QLLNGKLMATSYL-----ASVESLAESENE----------- 529
            .                       :|:..:..::|.|     |:.:..|:..:|
Human    90 RMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDS 154

  Fly   530 ------LGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLR--------VD 580
                  :.|....|.:..:::...||:::||::|:||..:::.||.      |:|        .:
Human   155 NGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLD------CIRDQTKLPLGTE 213

  Fly   581 ELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLL 645
            |...||.||::||.|||.|||.|.|...||..||.||:...:.|.:||.|||:||.::::||:.:
Human   214 ERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECM 278

  Fly   646 QATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKE------VVEAHVIM 704
            :...........|:.|:|.|||||||||||||||||||||..:..|.| |:      |::|...|
Human   279 RNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLD-KDTEGYDVVLDAIDTM 342

  Fly   705 RQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNK-QRLVLLFATML 768
            ::||.:|:.:|||.|...|::|:..:|..|.||:||..|||..||....|..| :|.:.||..:|
Human   343 QRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLL 407

  Fly   769 IITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIK 833
            :|||:::| ...:|.:|...||||.|.:|.||.||.|..:..|:.|..:.|:::..||:|..|:|
Human   408 LITKKRDD-TFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLK 471

  Fly   834 GVMLEK--LDIPMRAKELVYQLGNEEDR--------TPDRSTWKWSLHSGSNSTPTYLERRNACR 888
            .::||.  ..||.:||:.:.::    |.        :|:..| |....|...|.|..|.     |
Human   472 RLILENHAAKIPAKAKQAILEM----DAIHHPGFCYSPEGGT-KALFGSKEGSAPYRLR-----R 526

  Fly   889 RSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNS-LDDTALQKLAA--A 950
            :||...|:.|..:   .:.::.|....|.|:....:|.|:|| |..||:. ...|.:..|.|  |
Human   527 KSEPSSRSHKVLK---TSETAQDIQKVSREEGSPQLSSARPS-PAQRNSQPSSSTMISVLRAGGA 587

  Fly   951 MRYRKRDAAVKEETKTPVKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERS 1015
            :|....|..:::......:.|.:.:.|....:...|            :.|.|.:.|.:..::.:
Human   588 LRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVP------------SFSSSDLNSTRLCEDST 640

  Fly  1016 KSVP---RIGGFSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIA 1077
            .|.|   .:|          :.|..|.|::..|      ..|:....|       ...|.|.:|.
Human   641 SSRPCSWHMG----------QMESTETSSSGHR------IVRRASSAG-------ESNTCPPEIG 682

  Fly  1078 NLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKITESTEELRPDG-EIELAQEAATLDE------- 1134
            ...:.|               |..:|..     ||..||:.|.| .|||     |:|:
Human   683 TSDRTR---------------ELQNSPK-----TEGQEEMTPFGSSIEL-----TIDDIDHVYDN 722

  Fly  1135 -STQDQYYSPDHETELLSPAEKSKRDAQIVLDLLKNSKEFERIYNKQQKRRESPVSPVSPDISRG 1198
             |.:|.........|..|...||.||:      ::.....|..:.|:|...           |:|
Human   723 ISYEDLKLMVAKREEAESTPSKSARDS------VRPKSTPELAFTKRQAGH-----------SKG 770

  Fly  1199 PILPPPRPPSRSPPPLELEEQEKKPVEEVDSVSEEPIYETLLRNVHVP------YKFSPVLGRAK 1257
            .:.      :::...|...|...:...|:.:| ||.||:|    :.:|      :|.|. |.|||
Human   771 SLY------AQTDGTLSGGEASSQSTHELQAV-EENIYDT----IGLPDPPSLGFKCSS-LKRAK 823

  Fly  1258 SSQILKKRS------KTAPAASR----------------PESDYVTLVY-SPEG--------VLQ 1291
            .|..|...:      ...|..|:                |:..|::|:| ||.|        |..
Human   824 RSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSD 888

  Fly  1292 RVGEEV---------------------------VQRDSCSSSTTSTSSNGSGSTLKRDSQSTVIN 1329
            ::.|||                           |.:|.......:.|:    ..|.||...:|..
Human   889 KLSEEVDEIWNDLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAEST----PELSRDVGRSVST 949

  Fly  1330 LLMEAAQEHESRPL--PKNSVSGS--------ESSLLPR--ALKSIDNLSMA------------- 1369
            |.:.     ||:.|  |..|.:|.        |..|:.:  :..|::.||:|
Human   950 LSLP-----ESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLA 1009

  Fly  1370 -FGRSNRPPER-----RVSDVSEMCRQSVLHRQGSEAVGE-----RMAHVDYADPKALFGLGVLN 1423
             .|.|...||.     ..:|.:: .|..::.||.|:.:.:     ::..::...|.|
Human  1010 NSGLSQTDPENPDLGMEATDKTK-SRVFMMARQYSQKIKKANQLLKVKSLELEQPPA-------- 1065

  Fly  1424 HSERDSVFSLTSSSSDSMCE------QQRKRSG--VGATFEYEQQVEDSLENDFRDSAI------ 1474
                       |....||.:      :::|:.|  :||......|:.|.:.  ||:|.:
Human  1066 -----------SQHQKSMHKDLAAILEEKKQGGPAIGARIAEYSQLYDQIV--FRESPLKIQKDG 1117

  Fly  1475 YSDDNEKR-------------SGDYDVHLRRPSSP-----PPPPPPLGPR-----------PHQP 1510
            ::...|..             |||:.:|....:..     .||...|..|           |.|.
Human  1118 WASPQESSLLRSVSPSQVHHGSGDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQL 1182

  Fly  1511 PQIAPKPS---KDQL--IQQRSGVIVCQSASRSWVLQQIEN 1546
            ......||   .|.|  ..||..|:|.|....:|....:.|
Human  1183 SAACSVPSLQTSDPLPGSVQRCSVVVSQPNKENWCQDHLYN 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	75/178 (42%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	56/151 (37%)
PLEKHG1	NP_001316727.1	RhoGEF	176..351	CDD:279015	75/181 (41%)
		PH_PLEKHG1_G2_G3	332..477	CDD:270063	55/145 (38%)
		PH	381..474	CDD:278594	36/93 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4843
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004049
OrthoInspector	1	1.000	-	-		otm41567
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X3795
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.040