DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GEFmeso and Vav3

DIOPT Version :9

Sequence 1:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001365916.1 Gene:Vav3 / 57257 MGIID:1888518 Length:875 Species:Mus musculus


Alignment Length:829 Identity:173/829 - (20%)
Similarity:305/829 - (36%) Gaps:192/829 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   460 ESLDRLTDIKPKFAARLSELARLNNRPLS-SSSICSTSSSSSSGSDQLLNG--KLMATSYLASVE 521
            |:.| |.|:: .|...:..|:||:..|:: ::.|....:..|...:.:..|  .|:..:.:...|
Mouse    95 EAFD-LFDVR-DFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETRVEDEE 157

  Fly   522 SLAE---SENELGD-----------QHHPPAMSVLEKTCL-EIVDSERSFVEDLGQVIKGYLQDW 571
            .|.:   .|:|.|:           |......:.:...|| ||..:|..:.|.|..:.|.::...
Mouse   158 DLYDCVYGEDEGGEVYEDLMKAEEAQQPKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPL 222

  Fly   572 KERACLRVDELQILFANIEEIYEFNSMLLQRLINT--GRDPGRIARCFIDLRDGFDVYTTYCTSY 634
            |.  .|...|...:|.||.::.:.:..|:|.:.::  .:|...:.:.||:.::...:|..||:..
Mouse   223 KR--FLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDQNLYQVFINYKERLVIYGQYCSGV 285

  Fly   635 PEAISLLTKLLQATHTYSL-LASTQKLLQH-RLPLGSYLLKPVQRILKYHLLLDSLRKH------ 691
            ..|||.|..:.:......| |....|...: :..|...|:.|:||:|||||||..|.||      
Mouse   286 ESAISNLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTHDPME 350

  Fly   692 -CDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLL---- 751
             .::|..::|   |:.:|..:::|||..|....:|:....::. |...:.:.|..:.:|.:    
Mouse   351 KANLKLALDA---MKDLAQYVNEVKRDNETLREIKQFQLSIEN-LNQPVLLFGRPQGDGEIRITT 411

  Fly   752 MEQHNKQ-RLVLLFATMLIITKQKEDGR-----LQFKTYISQNNLMLSEHLPGEPTSFYVIPFDE 810
            :::|.|| |.:.||...:|:.|:|.|..     :..:.|...||....:........||:| ..:
Mouse   412 LDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLI-HTQ 475

  Fly   811 PRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSN 875
            .::.::...:.:|.|:.|        ||:.::         .|.|......|.:...:.:|:   
Mouse   476 GQNGLEFYCKTKDLKKKW--------LEQFEM---------ALSNIRPDYADSNFHDFKMHT--- 520

  Fly   876 STPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEE-----ESISQAKPSKPLAR 935
                 ..|..:||..::..|.: |.:..:.......:..|.|.:.:     .|:.|.....|..|
Mouse   521 -----FTRVTSCRVCQMLLRGT-FYQGYLCFKCGAKAHKECLGRVDNCGRVNSVEQGPFKPPEKR 579

  Fly   936 NNSLD------DTALQKLAAAMRYRKRDAAVKEETKTPV----KEPCKCDQDAKQDERIEPCSCI 990
            .|.|.      |..|.|:.....|          |.||.    :.|   ....:..:.:|    :
Mouse   580 TNGLRRASRQVDPGLPKMQVIRNY----------TGTPAPGLHEGP---PLHIQAGDTVE----L 627

  Fly   991 LRD-------QRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDE--EAEREREQDEDSAASLRG 1046
            ||.       |....|..:...|...|:|. |..||:...:|...  ....||.|.|....: |.
Mouse   628 LRGDAHSVFWQGRNLASGEVGFFPSDAVKP-SPCVPKPVDYSCQPWYAGPMERLQAETELIN-RV 690

  Fly  1047 SKPDLSERKTKGKGFFEVK-QYNHKTMPKK---------IANLKKQRSSTTKSCSRFYMDLSEFD 1101
            :...|...:||..|.:.:. :||::....|         ||..:|.:|         .|:|.|:.
Mouse   691 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKS---------LMELVEYY 746

  Fly  1102 SSSSTVLKITESTEELRPDGEIELAQEAATLDESTQDQYYSPDHETELLSPAEKSKRDAQIVLDL 1166
            ...|                   |.:...|||.:.|..|..|:      .||             
Mouse   747 KHHS-------------------LKEGFRTLDTTLQFPYKEPE------QPA------------- 773

  Fly  1167 LKNSKEFERIYNKQQKRRESPVSPVSPDISRGPILPPPR----PPSRSP 1211
                        .|:..|....||  |.......:.||.    |||.:|
Mouse   774 ------------GQRGNRTGNSSP--PLFCGFSFVTPPDYSFVPPSSTP 808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEFmesoNP_788403.2 RhoGEF 548..713 CDD:279015 46/175 (26%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 32/154 (21%)
Vav3NP_001365916.1 CH_VAV3 2..118 CDD:409113 8/24 (33%)
RhoGEF 193..369 CDD:238091 48/180 (27%)
PH_Vav 383..506 CDD:269930 26/141 (18%)
C1_VAV3 506..564 CDD:410419 9/66 (14%)
SH3_VAV3_1 596..657 CDD:212914 13/77 (17%)
SH2_Vav3 666..768 CDD:198270 27/130 (21%)
SH3_VAV3_2 819..874 CDD:212911
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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