DRSC/TRiP Functional Genomics Resources

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Protein Alignment GEFmeso and prex1

DIOPT Version :9

Sequence 1:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_699627.3 Gene:prex1 / 570984 ZFINID:ZDB-GENE-030131-1428 Length:1622 Species:Danio rerio


Alignment Length:1258 Identity:253/1258 - (20%)
Similarity:448/1258 - (35%) Gaps:417/1258 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   523 LAESENELGDQHHPPAMSVLE-------KTCL--EIVDSERSFVEDLGQVIKGYLQDWKERA--- 575
            ::|...|..:||....:|..:       :.|:  ||:::||.:|.:|..:...:||..::.|   
Zfish     1 MSEINTEEDNQHENECLSGKDSDRQLRLRLCVLNEILNTERDYVRNLTFLQSAFLQRIRQTAENQ 65

  Fly   576 -CLRVDELQILFANIEEIY----EFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYP 635
             ||..:::::||:|||.|.    ||.|.|...|....:....:...|:..:..|.||..||:::.
Zfish    66 QCLTQEQVKVLFSNIESILDVHREFLSTLDASLQPEPQAHHSLGHVFLQFKVRFSVYGEYCSNHE 130

  Fly   636 EAISLLTKLLQATHTYSLLASTQKLLQHR---LPLGSYLLKPVQRILKYHLLLDSL-----RKHC 692
            :|:.||.:|.:..|..:.|.....|...:   :||..|||.|:|||.||.|||..|     :||.
Zfish   131 KALRLLMELNKIPHIRAFLLHLMLLGGKKSTDVPLEGYLLSPIQRICKYPLLLRELLKRTPKKHS 195

  Fly   693 DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELT-VLGELRQEGLLME--- 753
            |...|.||...|:.|..||::.||:.|:...::.|...::||.|..|| :..||..:|.|::   
Zfish   196 DYPAVEEALQAMKAVCCNINETKRQMEKLEALEILQSHIEGWEGTNLTDICTELLLQGNLLKISA 260

  Fly   754 QHNKQRLVLLFATMLIITKQKE--DGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIK 816
            .:.::|:..||..:|:..|:|.  .|:...|...|.|.                     |::..:
Zfish   261 GNIQERVFFLFDNLLVYCKRKSRVSGKKSTKRTKSING---------------------PQYVFR 304

  Fly   817 LTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYL 881
                    .||.|:                   |.::.|.||.|.|..:..:::.:|.....|..
Zfish   305 --------GRINTE-------------------VMEVENVEDGTADYHSNNYTVTNGWKIHNTAK 342

  Fly   882 ERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEE-SISQAKPSKPLARNNSLDDTALQ 945
            .:...|     ..:|::.|:|.:      |:..:..||.|. .:...:.:..:.....      :
Zfish   343 NKWFVC-----MAKNAEDKQKWL------DAILKEREQRESLKLGMERDAYVMIAEKG------E 390

  Fly   946 KLAAAMRYRKRDAAVKEETKTPVKEPCKC-------------DQDAKQDERIEPCSCILRDQRSR 997
            ||...|..:.|. .:|:..:.....| ||             .:.:|.:|.|.....:|      
Zfish   391 KLYHMMMTKNRH-LIKDRRRKLTNVP-KCFLGNEFVSWLLESGEISKAEEGINLGQALL------ 447

  Fly   998 SAKSQSPVFSYKALKERSKSVPRIGGFSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKGFF 1062
                ::.:..:.:.|.:.|:...:..|..|:...:.|.:.||..              :||...:
Zfish   448 ----ENGIIHHVSDKHQFKNEQVLYRFRYDDGTYKARSEMEDII--------------SKGVRLY 494

  Fly  1063 ---------EVKQYNHKTMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKITESTEELR 1118
                     .||..:|        :||     |.||                 |:..::..|.|.
Zfish   495 CRLHSLFTPVVKDRDH--------HLK-----TFKS-----------------VIPASKLVEWLV 529

  Fly  1119 PDGEIELAQEAATL--------------------DESTQDQYYSPDHETELLSPAEKSKR-DAQI 1162
            ..|:....::|.||                    |||...::|: |.|||..|...|..| |.::
Zfish   530 SQGDSASREDAVTLGVGLCNAGFMHHVLEKSEFKDESQFFRFYA-DEETEGTSSKSKQLRSDFKL 593

  Fly  1163 VLDLLKNS-----KEFERIYNKQQKRRESPVSPVSPDISRGPILPPPRPPSRSPPPLELEEQEKK 1222
            :.::|..|     :|.:..:..::|.:    :.:...:|||..               .|....:
Zfish   594 IENILAKSLVIHPEEEDYGFEIEEKNK----AIIVKSVSRGSY---------------AEMAGLQ 639

  Fly  1223 PVEEVDSVSEEPIY-------ETLLRNVHVPYKFSPVLGRAKSSQI------------------- 1261
            |..::.|::|:.::       ||::.......:...:|...|:.:|                   
Zfish   640 PGRKIYSINEDLVFLRPFSEVETMINQSFCIRRSLRLLVATKNKEIVKIPDVHGTLPFVLSGSCP 704

  Fly  1262 -----LKKRSKTAPAASRP-------------ESDYVTLV-----YSPEGVLQ-----------R 1292
                 :||.|:.|.|..:|             :|.|..::     |.|  ||:           |
Zfish   705 PHIHAVKKGSEAAAAGLQPGQCVLKVNGNNMNQSGYQEVLEHFSGYQP--VLEQQDTSCGQWAYR 767

  Fly  1293 VGEEVVQRDS---CSSSTTSTS--SNGSGSTLKRDSQS----------TVINLLME--------- 1333
            |.|:|.::.|   |.:.:.|..  :||:||..:.:..|          .|.|:.:|         
Zfish   768 VYEDVEEQMSFRGCENGSDSEDGCTNGTGSVRRLEQLSISDDGPLVSLNVDNVHVEHGVVYEYVS 832

  Fly  1334 -AAQEH---ESRPLPKNSVSGSESSLLPRALKSIDNLSMAFGRSNR------------PP----- 1377
             |..:|   |....||...     :|..:.||:.......|.:|.|            |.     
Zfish   833 PAGIKHCVLEKMVEPKGCF-----NLTAKILKAFVKDDSLFVKSCRQLMALNDKVVTMPQFEFRN 892

  Fly  1378 ---------ERRVSD----VSEM---------------------------CRQSVLH---RQGSE 1399
                     ::|:|.    |.|:                           |..:::.   .:.:.
Zfish   893 ICDTKLESIDKRISSYKQFVEELQTKAWPTFKQASTKPHILGCMDFVPTNCHLNLMQVSCPKNTS 957

  Fly  1400 AVGERMAHVDYADPKALFG-------LGVLNHSERDSVFSLTSSSSDSM-C-------------- 1442
            :.| |...:.:....:.||       |..::|    ||..:||..:.|. |              
Zfish   958 SAG-RAFSIRFGRKNSFFGLDPDQANLNPMSH----SVHCVTSMGAPSFSCQSLDEETENGEGNS 1017

  Fly  1443 EQQRKRSGVGATFEYEQQVEDSLEN-----DFRDSAIYSDDNEKRSGDYDVHLRRPSSPPPPPPP 1502
            |..||....|.:|..:|:..:|.:|     :..|.|:  .:.::.....||.|   ||...|..|
Zfish  1018 EDSRKHEEGGLSFLLKQEDTESQDNYICLYNRLDIAV--REMKQYVAQIDVLL---SSITGPTQP 1077

  Fly  1503 LGPRP---HQPPQIAPKPSK-DQ 1521
            .|..|   ...|..:|.|.: ||
Zfish  1078 QGSEPPSFESGPSTSPIPEETDQ 1100

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEFmesoNP_788403.2 RhoGEF 548..713 CDD:279015 60/180 (33%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 34/150 (23%)
prex1XP_699627.3 RhoGEF 32..216 CDD:279015 60/183 (33%)
PH_Collybistin_ASEF 221..372 CDD:269931 40/209 (19%)
PH 249..363 CDD:278594 30/172 (17%)
DEP 390..470 CDD:295306 14/91 (15%)
DEP_2_P-Rex 482..574 CDD:239887 23/136 (17%)
PDZ 600..678 CDD:214570 12/96 (13%)
PDZ_signaling 684..745 CDD:238492 9/60 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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