DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and spata13

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_005162798.1	Gene:	spata13 / 568426	ZFINID:	ZDB-GENE-091116-25	Length:	1251	Species:	Danio rerio

Alignment Length:	964	Identity:	207/964 - (21%)
Similarity:	336/964 - (34%)	Gaps:	264/964 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSG----------DSTPKRSN----- 68
            ||.:|...:||                     ||:|...:.|          |.|.||.|
Zfish   300 SSVDLQEHVLG---------------------SHQSPMRTRGHLQKLVGSLTDLTVKRKNIASPS 343

  Fly    69 -----SNCSSSSSTGSSTGSC----------SSVPTSDDQSASYTLASSSTHLGHQEPPAPLV-V 117
                 |..|......|....|          |.|||...|.::    ..:..:.|..|..|.| :
Zfish   344 PRVPVSPLSQLHDDYSRRTPCVPTSGRQRRPSPVPTKTQQDST----CQTIPILHPAPSCPAVFI 404

  Fly   118 AGLRD--EPDG---AQLSRLVQRRSQESQIHGSSSSIA-----------SSGSSRRGSNI--RIL 164
            :.|.|  ||..   |.:|..||.....|::|...|:..           .:|.:...|.|  :..
Zfish   405 SDLDDSLEPPSKTTALISDYVQMAVSSSELHIGDSACPPEKYCEPMECHQNGLNDHYSQIPQQCS 469

  Fly   165 SPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTP---------------- 213
            ||.:...:..:|:......:.|......:.|..:.....::|:..:.||
Zfish   470 SPCLKPTVNGNDVNLQCLWTEERETDDLEASSDNRITRAFLKSDEASTPAASPITNSCCSESPLG 534

  Fly   214 -PAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKP-QDEDRTPT 276
             |...::|.. :|..|.|.:..|.:.:|....||.:..    |.|..|...|:.:. ::.|.|..
Zfish   535 TPTTPNSPAF-VSASPTSVVPRKRAGRSKPRPVSDYGQ----LASSKFCILEEDRELENMDYTSQ 594

  Fly   277 NKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPA----TP 337
            ...:....:.....|..|...|......::.|.:|....|  .|:|....|..|...|:    .|
Zfish   595 KDYISNGSYIESSRPENGHVCTQKESRKRRPISVIGGVDL--YSSQPAEQKDDTESLPSPVCRPP 657

  Fly   338 TPS-------ATKAKEFVC----SEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEA 391
            .||       |..|:...|    |.|         |..|.:.:...|..|:| |..||..|  ::
Zfish   658 VPSHRVPPYRAVSARLRPCVFSQSTP---------IGLDRMGRRKGRRVLSD-GSSDPMLE--DS 710

  Fly   392 VNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLA---ELEE 453
            |::.                                ......|..|.|...|..:...   .:|.
Zfish   711 VSEE--------------------------------DGSFEELTEGTPYLQPEVDLFTLNQHIES 743

  Fly   454 ANKLSAESL-DRLTDIKPKFAARLSELAR-------------LNNR----PLSSSSICSTSSSSS 500
            ...:.||:| |.:|..:.:.|.:..|:.|             :.:|    |.|...:......||
Zfish   744 GRAVYAEALWDHVTMEEQELAFKAGEVIRVLDVQEQDWWWGMVGDREAWFPSSFVRVRVNQEDSS 808

  Fly   501 SGSDQLLNGKLMATSYLASVESLAESENEL-GDQH-----HPPAMSVLEKTCLEIVDSERSFVED 559
            |                .||||..::|..: .|.|     |...|..  ....||:|:||.:::.
Zfish   809 S----------------ESVESTPDTEEPIPSDSHKQNPEHRKQMRA--NVVKEIMDTERVYIKH 855

  Fly   560 LGQVIKGYLQDWKERACLRVD-ELQILFANIEEIYEFNSML---LQRLINTGRDP--GRIARCFI 618
            |..:.:||::..::...:..| :|:.:|:|||:||.|....   |:|..|. .:|  ..|..||:
Zfish   856 LKDICEGYIRQCRKHPGMFTDTQLKTIFSNIEDIYRFQRKFLKDLERKYNP-ENPHLSEIGSCFL 919

  Fly   619 DLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHR--LPLGSYLLKPVQRILKY 681
            ...:||.:|:.||.::|.|.:.|.:|::.:. |.......:|||..  :.:..:||.|||:|.||
Zfish   920 QQEEGFSIYSEYCNTHPVACAELQRLMKQSR-YKHFFEACRLLQQMIDISIAGFLLTPVQKICKY 983

  Fly   682 HLLLDSL-----RKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLG----- 736
            .|.|..|     ::|.|...|..||..|:.||..|::.||:.|....:......:..|.|
Zfish   984 PLQLGELLKYTPKEHSDFAGVCAAHKAMKNVASLINERKRRLESIDTIAHWQVAILHWAGEDVLA 1048

  Fly   737 --PELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGE 799
              .||...|||.:  ::.....:||...||...|:..|:.          :.:.:|:   |..|.
Zfish  1049 RSSELIHSGELTR--IVRPGKTQQRSYFLFDHQLVFCKKD----------VLRRDLL---HYRGR 1098

  Fly   800 PTSFYVIPFDEP----------------RHQIKLTA-------RNRDQKRIWTQ 830
            ..:..:.|.|.|                ||...|..       :::|::| |.|
Zfish  1099 MDTDLLEPSDLPDGRHTELGLLKNAFLLRHAENLNVLCVLCCKKSQDKQR-WLQ 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	57/177 (32%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	36/167 (22%)
spata13	XP_005162798.1	SH3	747..800	CDD:327375	11/52 (21%)
		RhoGEF	841..1020	CDD:214619	57/180 (32%)
		PH_Collybistin_ASEF	1025..1163	CDD:269931	27/143 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940