Protein Alignment GEFmeso and mcf2b

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_009303604.2
• Gene: mcf2b / 559907
• ZFINID: ZDB-GENE-091118-4
• Length: 1046
• Species: Danio rerio
• Alignment Length: 956
• Identity: 201/956 - (21%)
• Similarity: 336/956 - (35%)
• Gaps: 250/956 - (26%)

  Fly   239 QSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTP-TNKSVPGTPFHFDGHPFQGRKLTLPRY 302
            :.|.:|:|..::|.....:   ||.::...||::|.. ....:......|||. |:...|.|.:|
Zfish   154 REGRQLLSNLEASKAVEGA---AAEDRDISQDKERVQRLVAQLRDMEMAFDGF-FEKHHLKLQQY 214

  Fly   303 DS--QQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFV---CSEPLSPVDIVDTI 362
            ..  |..:...|||.: .....:.....|:.||....|....|..|.:   ..:.:....|:...
Zfish   215 LQLLQYELSFHEMEAI-LEKLNIQEKAIASVGTTVAQTEQLLKDLEMLENTAEDEMGRAQIIILH 278

  Fly   363 NFDLVAQHMERLTLADPGDLDPRAELIEAVNK-------------------TLVNKPLVRSSSAA 408
            ...|.|.|...|.|           :::..|:                   |.:...|:|.....
Zfish   279 GHQLAASHHYALAL-----------IVQRCNELRHHCDTLTTALRAKRASLTRIRDLLLRLEETV 332

  Fly   409 --C--ASTICSSPLLTYARTKSLGAKAS-----TLGGGVPIKLPTAEQLAELEEANKLSAESLDR 464
              |  .:.:.::.||...::|. ||:|:     ||....|..|.:...:..||....|:.:...:
Zfish   333 RWCDEGAYLLANQLLDKFQSKE-GAQAALRDIETLMETAPSVLRSNLDILNLEFQAVLTPQLQSQ 396

  Fly   465 LTDIKPKFA----------ARLSELARLNNRPL-------SSSSICST-----------SSSSSS 501
            :..:..|.:          |.|.:||.:..||:       .:|..|.:           :||...
Zfish   397 IESVTEKVSTVQGMIQSRQACLRKLADIQVRPIQLVAPRPETSPRCKSPLFSPKHSFDVNSSLRF 461

  Fly   502 GSDQLLNGKLMA-----TSYLASVESLAESEN---------ELGDQHHPPAMSVLEKTCLEIVDS 552
            ..|..|.||..:     |..:..:....|:.:         |..|||....|.       |::::
Zfish   462 SFDLALPGKKASRKGPNTKKIEVMHDYEENRSCLSYGPEGVENPDQHKRRVMK-------ELIET 519

  Fly   553 ERSFVEDLGQVIKGYLQDWKERACLRV------DELQILFANIEEIYEFNS-MLLQRLINTGRDP 610
            ||.:||:|..|:.||..:....|...:      ::.:.||.|:.|||:|:| :.||.|.:....|
Zfish   520 ERIYVEELMSVLLGYRAEMDNPALSNILPSVLRNKKEDLFGNLPEIYKFHSRIFLQDLESCLETP 584

  Fly   611 GRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPV 675
            .|:...|::.::.|.||..||.:.|.:.:|..:...:    :.:...:..|.|:|.|.|||||||
Zfish   585 ERVGARFLERKEHFQVYERYCQNKPRSDALWRQCSDS----AFIQECKGKLDHKLGLDSYLLKPV 645

  Fly   676 QRILKYHLLLDSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELT 740
            ||:.||.|||..|.||....:.  |..:...:...:|.:|...:...::.     :.|:.| ||:
Zfish   646 QRLTKYQLLLKELLKHSSNSQY--ASELQGALNAMLDLLKSVNDSMHQIS-----ITGYEG-ELS 702

  Fly   741 VLGELRQEGL--LMEQHNK--------------QRLVLLFATMLIITKQKE---DGRLQFKTYIS 786
            .||.:..:|.  :...|.|              ||.:.|....|:..|::|   :|..:..:|..
Zfish   703 DLGRVLMQGSFNVWINHKKGPTRMKDMARFKPMQRHLFLHERALLFCKKREETGEGHDRTASYSF 767

  Fly   787 QNNLMLS-----EHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRA 846
            ::.||:|     |::.|:...| .|.::.......:.|...|.|..|...|:.:
Zfish   768 KHCLMMSAVGITENVKGDVKKF-EIWYNGKEEVYVVQAPTVDVKIAWLTEIRKI----------- 820

  Fly   847 KELVYQLGNEE-----DRTPDRS----------------TWKWSL--------------HSGSNS 876
                  |.|::     |..||..                ...||.              ||....
Zfish   821 ------LNNQQKTVKGDSQPDGEQPLSPPLADSVRHISVCMPWSATQITGCSGCFDVLPHSKHQG 879

  Fly   877 TPTYLERRNACRRSEI---------RQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKP 932
            .....|..::.|.|.:         |.||.. :|.....|.|.| ..|.||.....:|.
Zfish   880 ASVSSEEADSGRVSPVLTDPVIISPRPRNHN-RRSWPGTSHSVD-ICEGLEDWTTDLSN------ 936

  Fly   933 LARNNSLDDTALQKLAAAMRYR---------KRDAAVK------------------------EET 964
            ::.::..||.    |....|||         |.|..:|                        .|.
Zfish   937 ISDSDEEDDV----LLVPGRYRAMLDHLKCGKDDVIIKCGDVIHVLQESVMGLWHVKNLTRGGEG 997

  Fly   965 KTPVKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKA 1010
            |.||....:...||.:...|:.......:.|..|..|..|...:||
Zfish   998 KLPVDTLLRMLGDAGRSPSIQSGGAGNINSRKPSNTSVHPPHVHKA 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	53/170 (31%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	32/168 (19%)
mcf2b	XP_009303604.2	None